9-isopropyl-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-amine | 1196531-06-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 9-isopropyl-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-amine
• 英文别名: N-[1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]amine；9-isopropyl-5-amino-benzonorbomene；5-amino-9-isopropyl-benzonorbornene；9-isopropyl-1,2,3,4-tetrahydro-1,4-methanonaphthalene-5-ylamine；9-isopropyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine；1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-amine；11-propan-2-yltricyclo[6.2.1.02,7]undeca-2(7),3,5-trien-3-amine
• CAS: 1196531-06-2
• 化学式: C₁₄H₁₉N
• 分子量: 201.312
• InChiKey: YHOQMAJZIIUYAZ-UHFFFAOYSA-N

物化性质

• 沸点：
  298.5±29.0 °C(Predicted)
• 密度：
  1.062±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-isopropyl-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-amine 在 5% active carbon-supported ruthenium 氢气 作用下， 以 四氢呋喃 为溶剂， 120.0 ℃ 、10.0 MPa 条件下， 反应 20.0h， 生成 9-isopropyldecahydro-1,4-methanonaphthalen-5-amine
  参考文献：
  名称：

  [EN] DECAHYDRO-1,4-METHANONAPHTHALEN CARBOXAMIDES
  [FR] DÉCAHYDRO-1,4-MÉTHANONAPHTALÈNE CARBOXAMIDES

  摘要：

  本发明涉及式(Ia)或(Ib)的十氢-1,4-甲基萘酰胺衍生物；它们的制备方法，它们作为杀菌剂的用途，特别是以杀菌剂组合物的形式，以及使用这些化合物或组合物控制植物病原真菌，特别是植物的方法。

  公开号：

  WO2012065932A1
• 作为产物：
  描述：

  9-isopropylidene-5-nitro-benzonorbornadiene 在 铑 碳 、 氢气 作用下， 以 四氢呋喃 为溶剂， 反应 96.0h， 以to afford the title compound as an 87:13 syn的产率得到9-isopropyl-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-amine
  参考文献：
  名称：

  PYRAZINYL CARBOXAMIDES AS FUNGICIDES

  摘要：

  本公开涉及吡嗪羧酰胺及其衍生物的领域，以及这些化合物作为杀菌剂的用途。

  公开号：

  US20110301178A1

文献信息

• Method for the Production of N-Substituted (3-Dihalomethyl-1-Methyl-Pyrazole-4-yl) Carboxamides
  申请人：Zierke Thomas

  公开号：US20100174094A1

  公开（公告）日：2010-07-08

  The present invention relates to a process for preparing N-substituted (3-dihalomethylpyrazol-4-yl)carboxamides of the formula (I) in which R 1 is optionally substituted phenyl or C 3 -C 7 -cycloalkyl, R 1a is hydrogen or fluorine, or R 1a together with R 1 is optionally substituted C 3 -C 5 -alkanediyl or C 5 -C 7 -cycloalkanediyl, R 2 is C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl or C 1 -C 4 -alkoxy-C 1 -C 2 -alkyl, X is F or Cl and n is 0, 1, 2 or 3; which comprises A) providing a compound of the formula (II) in which X is F or Cl, Y is Cl or Br and R 2 has one of the meanings given above and B) reacting a compound of the formula (II) with carbon monoxide and a compound of the formula (III) in which R 1 , R 1a and n have one of the meanings given above; in the presence of a palladium catalyst; to intermediates used for the preparation according to the process according to the invention, and also to processes for their preparation.

  本发明涉及一种制备式(I)的N-取代(3-二卤甲基吡唑-4-基)羧酰胺的方法 其中R1是可选的取代苯基或C3-C7环烷基，R1a是氢或氟，或者R1a与R1一起是可选的取代C3-C5-烷二基或C5-C7-环烷二基，R2是C1-C6-烷基，C2-C6-烯基，C2-C6-炔基或C1-C4-烷氧基-C1-C2-烷基，X是F或Cl，n为0、1、2或3；包括 A)提供式(II)的化合物 其中X是F或Cl，Y是Cl或Br，R2具有上述给定的含义之一 B)将式(II)的化合物与一氧化碳和式(III)的化合物反应 其中R1、R1a和n具有上述给定的含义之一；在钯催化剂的存在下； 用于根据本发明的方法制备的中间体，以及用于它们的制备的方法。
• PRODUCTION METHOD FOR PYRAZOLE-4-CARBOXAMIDE DERIVATIVE
  申请人：JAPAN FINECHEM COMPANY, INC.

  公开号：US20200181091A1

  公开（公告）日：2020-06-11

  The present invention relates to a method of producing a pyrazole-4-carboxamide derivative including subjecting a pyrazole-4-carboxylic acid ester and an amine to an aminolysis reaction in a solvent in the presence of a base, provided that the reaction is completed without removing a by-produced alcohol or phenol outside the system. An industrial production method of a pyrazole-4-carboxamide derivative which is useful as an agricultural fungicide, simply and in high yield and high purity as compared with the conventional method, is provided.

  本发明涉及一种生产吡唑-4-甲酰胺衍生物的方法，包括将吡唑-4-羧酸酯和胺在溶剂中在碱的存在下进行醇解反应，条件是反应完成后不将系统中产生的醇或酚去除。提供了一种作为农业杀菌剂的吡唑-4-甲酰胺衍生物的工业生产方法，与常规方法相比，该方法简单且以高收率和高纯度进行。
• Method For Manufacturing Aryl Carboxamides
  申请人：Reichert Wolfgang

  公开号：US20110054183A1

  公开（公告）日：2011-03-03

  A process for preparing arylcarboxamides of the formula (I) where Ar =a mono- to trisubstituted phenyl, pyridyl or pyrazolyl ring, where the substituents are selected from halogen, C i -C 4 -alkyl and C 1 -C 4 -haloalkyl; M =thienyl or phenyl, which may bear a halogen substituent; Q =direct bond, cyclopropylene, fused bicycio[2.2.1]heptane or bicyclo[2.2.1]heptene ring; R 1 =hydrogen, halogen, C 1 -C 6 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, mono- to trisubstituted phenyl, where the substituents are selected from halogen and trifluoromethylthio, or cyclopropyl; by reacting an acid chloride of the formula (II) with an arylamine (III) in a suitable nonaqueous solvent, wherein, in the absence of an auxiliary base, a) the acid chloride (II) is initially charged, b) a pressure of from 0 to 700 mbar is established, c) the arylamine (III) is metered in in an approximately stoichiometric amount and d) the product of value is isolated.

  一种制备式(I)的芳基羧酰胺的方法，其中Ar = 单取代至三取代苯基、吡啶基或吡唑基环，取代基选自卤素、Ci-C4-烷基和C1-C4-卤代烷基；M = 噻吩基或苯基，可以带有卤素取代基；Q = 直链键、环丙烯基、融合的双环[2.2.1]庚烷或双环[2.2.1]庚烯环；R1 = 氢、卤素、C1-C6-烷基、C1-C4-烷氧基、C1-C4-卤代烷氧基、单取代至三取代苯基，其中取代基选自卤素和三氟甲硫基，或环丙基；通过在适当的非水溶剂中将式(II)的酸氯与芳香胺(III)反应，其中，在没有辅助碱的情况下，a) 首先加入酸氯(II)，b) 建立0至700毫巴的压力，c) 以近似化学计量的量滴定芳香胺(III)，d) 分离所得产物的价值。
• [EN] PROCESS FOR THE PREPARATION OF AMIDES<br/>[FR] PROCÉDÉ POUR LA FABRICATION D'AMIDES
  申请人：SYNGENTA LTD

  公开号：WO2009138375A1

  公开（公告）日：2009-11-19

  The invention relates to a process for the preparation of fungicidally active compounds such as tricyclic amine derivatives(I). The process involves coupling of a carboxylic 5 acid e.g. a compound of formula (II) with an aniline, e.g. a compound of formula(III) in the presence of a boronic acid catalystor an antimony catalyst (II)(III)(I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Het are defined in the specification.

  本发明涉及一种制备具有杀真菌活性的化合物，例如三环胺衍生物（I）的方法。该方法涉及在硼酸催化剂或锑催化剂的存在下，将羧基5酸（例如化合物II）与苯胺（例如化合物III）偶联。（II）（III）（I）中，R1、R2、R3、R4、R5、R6、R7、X、Y和Het在规范中定义。
• [EN] PROCESS FOR THE PREPARATION OF PYRAZOLE-4-CARBOXAMIDES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE PYRAZOLE-4-CARBOXAMIDES
  申请人：SOLVAY

  公开号：WO2012055864A1

  公开（公告）日：2012-05-03

  The invention concerns a process for the manufacture of pyrazole-4-carboxamides, in particular, of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamides which are useful as pharmaceuticals and agrochemicals. The carboxamides are prepared from the corresponding pyrazole-4-carboxylic acid esters and appropriate amine in the presence of a base. The reaction is performed in a reaction medium which is essentially free of water; alternatively, the base is used in an amount equal to or greater than 0.25 equivalents per mole of amine.

  该发明涉及一种用于制备吡唑-4-羧酰胺的方法，特别是3-二氟甲基-1-甲基-1H-吡唑-4-羧酰胺，它们可用作药物和农药。这些羧酰胺是通过相应的吡唑-4-羧酸酯和适当的胺在碱的存在下制备的。反应在基本不含水的反应介质中进行；或者，碱的用量等于或大于每摩尔胺的0.25当量。