diethyl 4,5,7-tributyl-6-(trimethylsilyl)-1H-indene-2,2(3H)-dicarboxylate | 1416897-33-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: diethyl 4,5,7-tributyl-6-(trimethylsilyl)-1H-indene-2,2(3H)-dicarboxylate
• 英文别名: Diethyl 4,5,7-tributyl-6-trimethylsilyl-1,3-dihydroindene-2,2-dicarboxylate；diethyl 4,5,7-tributyl-6-trimethylsilyl-1,3-dihydroindene-2,2-dicarboxylate
• CAS: 1416897-33-0
• 化学式: C₃₀H₅₀O₄Si
• 分子量: 502.81
• InChiKey: BUYWFQLZWUYXDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.47
• 重原子数：
  35
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Diethyl 2,2-bis(hept-2-ynyl)propanedioate 、 1-三甲基硅烷-1-己炔 在 cobalt(II) chloride hexahydrate 、 邻苯二甲酸二甲酯 、 2-(((2,6-diisopropylphenyl)imino)methyl)pyridine 、 锌 作用下， 反应 12.0h， 以91%的产率得到diethyl 4,5,7-tributyl-6-(trimethylsilyl)-1H-indene-2,2(3H)-dicarboxylate
  参考文献：
  名称：

  Remarkable Activation of an Alkyne [2+2+2]-Cycloaddition Catalyst, 2-Iminomethylpyridine (dipimp)/CoCl2·6H2O/Zn, by a Phthalate Additive

  摘要：

  A catalyst for alkyne [2+2+2]-cycloaddition reactions, 2-(2,6-diisopropylphenyl)iminomethylpyridine (dipimp)/CoCl2 center dot 6H(2)O/Zn, can be effectively activated by addition of a catalytic amount of dialkyl phthalate to enable reactions that cannot proceed under unactivated conditions. The activation by adding phthalate was ligand- and solvent-dependent, and it was unique to dipimp and N-methyl-2-pyrrolidone (NMP). With use of diphosphine ligand instead of dipimp or with use of tetrahydrofuran (THF) instead of NMP, no activation by a phthalate additive was observed. This simple method of catalyst activation with use of inexpensive, commercially available compounds is highly practical and may find many applications.

  DOI：

  10.1055/s-0032-1317318

文献信息

• Remarkable Activation of an Alkyne [2+2+2]-Cycloaddition Catalyst, 2-Iminomethylpyridine (dipimp)/CoCl2·6H2O/Zn, by a Phthalate Additive
  作者：Sentaro Okamoto、Yu-ki Sugiyama、Takuma Kariwa、Tetsuya Sakurada

  DOI：10.1055/s-0032-1317318

  日期：——

  A catalyst for alkyne [2+2+2]-cycloaddition reactions, 2-(2,6-diisopropylphenyl)iminomethylpyridine (dipimp)/CoCl2 center dot 6H(2)O/Zn, can be effectively activated by addition of a catalytic amount of dialkyl phthalate to enable reactions that cannot proceed under unactivated conditions. The activation by adding phthalate was ligand- and solvent-dependent, and it was unique to dipimp and N-methyl-2-pyrrolidone (NMP). With use of diphosphine ligand instead of dipimp or with use of tetrahydrofuran (THF) instead of NMP, no activation by a phthalate additive was observed. This simple method of catalyst activation with use of inexpensive, commercially available compounds is highly practical and may find many applications.