3-Oxo-5-cyanopentanamid | 35159-06-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Oxo-5-cyanopentanamid
• 英文别名: 5-Cyano-3-oxopentanamide
• CAS: 35159-06-9
• 化学式: C₆H₈N₂O₂
• mdl: MFCD19209826
• 分子量: 140.142
• InChiKey: REAQMXHIFZTMRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  84
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Oxo-5-cyanopentanamid 、 3-氯苄溴 生成 2,2-Bis-(3-chloro-benzyl)-5-cyano-3-oxo-pentanoic acid amide
  参考文献：
  名称：

  3-Oxo-5-cyanopentanamide. Novel .beta.-oxo amide from meso-butadiene diepoxide

  摘要：

  DOI：

  10.1021/jo00985a039
• 作为产物：
  描述：

  氰化钾 、 Meso-1,2:3,4-二环氧丁烷 在 magnesium sulfate 作用下， 生成 3-Oxo-5-cyanopentanamid
  参考文献：
  名称：

  3-Oxo-5-cyanopentanamide. Novel .beta.-oxo amide from meso-butadiene diepoxide

  摘要：

  DOI：

  10.1021/jo00985a039

文献信息

• Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
  申请人：——

  公开号：US20040254167A1

  公开（公告）日：2004-12-16

  The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compound and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及抑制二肽基肽酶-IV酶（“DP-IV抑制剂”）的化合物，这些化合物对于治疗或预防二肽基肽酶-IV酶参与的疾病，如糖尿病，特别是2型糖尿病，是有用的。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗二肽基肽酶-IV酶参与的这些疾病中使用这些化合物和组合物。
• Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
  申请人：Liang Gui-Bai

  公开号：US20060211682A1

  公开（公告）日：2006-09-21

  The present invention is directed to hexahydrodiazepinone compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及六氢噻唑烷酮化合物，其是二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂，且在治疗或预防二肽基肽酶-IV酶参与的疾病，例如糖尿病和特别是2型糖尿病方面非常有用。本发明还涉及包含这些化合物的制药组合物，以及这些化合物和组合物在预防或治疗二肽基肽酶-IV酶参与的这些疾病中的使用。
• BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
  申请人：Merck & Co., Inc.

  公开号：EP1556362A2

  公开（公告）日：2005-07-27
• EP1556362A4
  申请人：——

  公开号：EP1556362A4

  公开（公告）日：2006-08-23
• HEXAHYDRODIAZEPINONES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
  申请人：Merck & Co., Inc.

  公开号：EP1651623A2

  公开（公告）日：2006-05-03