1,2-双(二苯基膦)乙烷(DPPE)是过渡金属催化剂中用途广泛且极其重要的配体。在这里,我们报道了容易获得的丙二烯基乙酸酯的二硫代膦酰化,以高产率和区域选择性生成 DPPE。该方案具有广泛的底物范围和温和的条件,避免使用过渡金属和空气敏感的磷源。机理研究表明该反应是通过 S N 2' 型加成-消除反应和 1,4-加成步骤完成的。
1,2-双(二苯基膦)乙烷(DPPE)是过渡金属催化剂中用途广泛且极其重要的配体。在这里,我们报道了容易获得的丙二烯基乙酸酯的二硫代膦酰化,以高产率和区域选择性生成 DPPE。该方案具有广泛的底物范围和温和的条件,避免使用过渡金属和空气敏感的磷源。机理研究表明该反应是通过 S N 2' 型加成-消除反应和 1,4-加成步骤完成的。
Anti-inflammatory 1-phenyl-2,3-butadien-1-ols, methods of use and
申请人:Sandoz, Inc.
公开号:US04032580A1
公开(公告)日:1977-06-28
Disclosed are compounds of the class 1-phenyl-2,3-butadien-1-ol e.g. 2-(p-biphenyl)-3,4-pentadien-2-ol, which are useful by reason of their pharmacological activity in animals, e.g., as anti-inflammatory agents and tranquilizers. Said compounds can be prepared, e.g., by reduction of a corresponding 4-substituted-1-phenyl-2-butyne-1-ol with a complex hydride such as lithium aluminum hydride.
The first facile, efficient, atom-economical and regioselective palladium-catalyzed direct C–P cross-coupling of unprotected allenic alcohols with H-phosphonates for the one-pot synthesis of structurally diverse multisubstituted 2-phosphinoyl-1,3-butadienes was developed. This strategy would enrich the allene chemistry and afford new scaffolds to construct complex molecular skeletons.