methyl 3-[3-butoxy-4-(5-methylaminomethylthiophen-3-yl)phenyl]propionate | 887921-67-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: methyl 3-[3-butoxy-4-(5-methylaminomethylthiophen-3-yl)phenyl]propionate
• 英文别名: methyl 3-[3-butoxy-4-[5-(methylaminomethyl)thiophen-3-yl]phenyl]propanoate
• CAS: 887921-67-7
• 化学式: C₂₀H₂₇NO₃S
• 分子量: 361.505
• InChiKey: VLYYNRIVDRFKQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  75.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 3-[3-butoxy-4-(5-methylaminomethylthiophen-3-yl)phenyl]propionate 、 间甲氧基苯甲酰氯 在 dimethylaminopyridine 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以70%的产率得到methyl 3-[3-butoxy-4-(5-{[(3-methoxybenzoyl)-methylamino]methyl}thiophen-3-yl)phenyl]propionate
  参考文献：
  名称：

  WO2006/53791

  摘要：

  公开号：
• 作为产物：
  描述：

  methyl 3-(3-bytoxy-4-{5-[(tert-butoxycarbonyl-methylamino)methyl]thiophen-3-yl}phenyl)propionate 在 三氟乙酸 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.0h， 以100%的产率得到methyl 3-[3-butoxy-4-(5-methylaminomethylthiophen-3-yl)phenyl]propionate
  参考文献：
  名称：

  WO2006/53791

  摘要：

  公开号：

文献信息

• Novel biaromatic compounds that modulate PPARgamma type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Boiteau Jean-Guy

  公开号：US20080027077A1

  公开（公告）日：2008-01-31

  Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/of diseases related to the metabolism of lipids), or, alternatively, in cosmetic compositions.

  具有一般式(I)的新型双芳香族化合物及其所含的化妆品/药物组合物在人类或兽医学中（在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域）或者在化妆品组合物中是有用的。
• Biaromatic compounds that modulate PPARgamma type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Galderma Research & Development

  公开号：US08129416B2

  公开（公告）日：2012-03-06

  Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/of diseases related to the metabolism of lipids), or, alternatively, in cosmetic compositions.

  具有通式（I）的新型双芳香化合物和由此组成的化妆品/药物组合物在人类或兽医学中（在皮肤病学以及心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域中）非常有用，或者在化妆品中使用。
• NOVEL BIAROMATIC COMPOUNDS THAT MODULATE PPARy TYPE RECEPTORS AND COSMETIC/PHARMACEUTICAL COMPOSITIONS COMPRISED THEREOF
  申请人：BOITEAU Jean-Guy

  公开号：US20120121527A1

  公开（公告）日：2012-05-17

  Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/of diseases related to the metabolism of lipids), or, alternatively, in cosmetic compositions.

  具有一般式(I)的新型双芳香族化合物及其所包含的化妆品/药物组合物在人类或兽医学领域（在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域）中非常有用，或者在化妆品组合物中使用。
• NOVEL BIAROMATIC COMPOUNDS THAT MODULATE PPARY TYPE RECEPTORS AND COSMETIC/PHARMACEUTICAL COMPOSITIONS COMPRISED THEREOF
  申请人：Galderma Research & Development

  公开号：US20130303549A1

  公开（公告）日：2013-11-14

  Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/of diseases related to the metabolism of lipids), or, alternatively, in cosmetic compositions.

  具有通式(I)的新型双芳香化合物及其所包含的化妆品/药品组合物在人类或兽医医学上具有用途（在皮肤科，以及心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域），或者在化妆品组合物中也可以使用。
• Biaromatic compounds that modulate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Boiteau Jean-Guy

  公开号：US08513297B2

  公开（公告）日：2013-08-20

  Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/of diseases related to the metabolism of lipids), or, alternatively, in cosmetic compositions.

  具有通式（I）的新型双芳香化合物以及由此组成的化妆品/医药组合物在人类或兽医学（在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域）中有用，或者在化妆品组合物中有用。