2-甲基-3-壬醇 | 26533-33-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-甲基-3-壬醇
• 英文名称: 2-Methyl-nonan-3-ol
• 英文别名: 2-Methyl-3-nonanol；2-methylnonan-3-ol
• CAS: 26533-33-5
• 化学式: C₁₀H₂₂O
• 分子量: 158.284
• InChiKey: OFIYMUXECPHIPZ-UHFFFAOYSA-N

物化性质

• 熔点：
  -1.53°C (estimate)
• 沸点：
  208.4°C
• 密度：
  0.8245

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  庚醛 、 chloromanganese(1+),propane 以71%的产率得到
  参考文献：
  名称：

  CAHIEZ G.; FIGADERE B., TETRAHEDRON LETT., 27,(1986) N 37, 4445-4448

  摘要：

  DOI：

文献信息

• Catalytic enantioselective reactions. Part 18: 1 Preparation of 3-deoxy-3- N , N -dialkylamino-1,2;5,6-di- O -isopropylidene- d -altritol derivatives from d -mannitol and their applications for catalytic enantioselective addition of dialkylzinc to aldehydes
  作者：Byung Tae Cho、Yu Sung Chun、Weon Ki Yang

  DOI：10.1016/s0957-4166(00)00183-x

  日期：2000.6

  N-dialkylamino-1,2;5,6-di-O-isopropylidene-d-altritol derivatives 2–4 possessing a variety of amine substituents at the 3-position and thiol or acetylthio group at the 4-position was prepared from d-mannitol and enantioselective additions of diethylzinc to aldehydes using them as chiral catalysts were examined.

  一系列的新的手性β氨基醇，3-脱氧-3- Ñ，Ñ二烷基氨基-1,2; 5,6-二- ö异亚丙基d-阿卓糖醇衍生物2 - 4在具有多种胺取代基的由d-甘露糖醇制备3-位和4-位的硫醇或乙酰硫基，并研究了将它们作为手性催化剂将二乙基锌对映体选择性加成到醛中的方法。
• [EN] PROCESSES FOR THE PRODUCTION OF ESTERS<br/>[FR] PROCÉDÉS DE PRODUCTION D'ESTERS
  申请人：EXXONMOBIL CHEM PATENTS INC

  公开号：WO2012025308A1

  公开（公告）日：2012-03-01

  A process for production of C4 to C15 esters by the esterification of a carboxylic acid or anhydride with a C4 to C15 alcohol including forming a reaction mixture of the acid or anhydride and the C4 to C15 alcohol including a stoichiometric excess of the alcohol and bringing the mixture to reaction temperature by providing an energy supply to the reaction to cause the mixture to react wherein initially the energy supply is reduced to reduce foaming and optionally the energy supply is subsequently increased to enhance reaction time.

  通过将羧酸或酐与C4至C15醇酯化，生产C4至C15酯的工艺包括形成酸或酐和C4至C15醇的反应混合物，其中包括醇的化学计量过剩，并通过向反应提供能量供应使混合物达到反应温度以引起混合物反应的步骤，其中最初减少能量供应以减少起泡，随后可选择增加能量供应以增强反应时间。
• [EN] PROCESS<br/>[FR] PROCÉDÉ
  申请人：PHOSPHAGENICS LTD

  公开号：WO2018112512A1

  公开（公告）日：2018-06-28

  An efficient and commercial phosphorylation process of a complex alcohol, such as secondary and tertiary alcohols, with P4O10 at high temperatures, and a product obtained by the process.

  一种高效商业化的磷酸酯化过程，用于复杂醇类（如二级和三级醇），在高温下使用P4O10，以及该过程得到的产品。
• [EN] PHENYLENE OXO-DIESTER PLASTICIZERS AND METHODS OF MAKING<br/>[FR] PLASTIFIANTS OXO-DIESTERS DE PHÉNYLÈNE ET PROCÉDÉS DE FABRICATION
  申请人：EXXONMOBIL RES & ENG CO

  公开号：WO2011041349A1

  公开（公告）日：2011-04-07

  A process for making non-phthalate, 1,2-phenylene oxo-diester plasticizers for polymer compositions, by selectively hydrogenating naphthalene to form a partially hydrogenated naphthalene, oxygenating said partially hydrogenated naphthalene to form phenylene diacids, and esterifying said phenylene diacids with oxo-alcohols to form 1,2-phenylene oxo-diesters. Also a process for making phenylene oxo-diester plasticizers by selectively brominating xylenes to form bisbromomethylbenzene, catalytic carboalkoxylation of the bromo-compound to form phenylene diacetate, followed by transesterification to form the phenylene oxo-diester.

  一种制造非邻苯二甲酸酯、1,2-苯基氧代二酯增塑剂用于聚合物组合物的方法，通过选择性加氢萘形成部分加氢萘，将部分加氢萘氧化成苯基二酸，然后酯化苯基二酸与氧代醇形成1,2-苯基氧代二酯。另外一种制造苯基氧代二酯增塑剂的方法是通过选择性溴化二甲苯形成双溴甲基苯，催化羧酸酯化溴化合物形成苯基二乙酸酯，然后通过酯交换反应形成苯基氧代二酯。
• [EN] CARBORANE COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS CARBORANE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2017049307A1

  公开（公告）日：2017-03-23

  Disclosed herein are compounds comprising dicarba-closo-dodecaborane. The compounds can be, for example, estrogen receptor beta (ERβ) agonists. In some examples, the compounds can be selective ERβ agonists. Also provided herein are methods of treating, preventing, or ameliorating cancer in a subject, suppressing tumor growth in a subject, treating an inflammatory disease in a subject, treating a neurodegenerative disease in a subject, treating a psychotropic disorder in a subject, or a combination thereof, by administering to a subject a therapeutically effective amount of one or more of the compounds or compositions described herein, or a pharmaceutically acceptable salt thereof.

  本文披露了包含二硼十二烷二酸的化合物。这些化合物可以是雌激素受体β（ERβ）激动剂。在某些情况下，这些化合物可以是选择性ERβ激动剂。本文还提供了通过向受试者施用本文描述的一个或多个化合物或组合物的治疗学有效量或其药用盐，治疗、预防或缓解受试者的癌症，抑制受试者的肿瘤生长，治疗受试者的炎症性疾病，治疗受试者的神经退行性疾病，治疗受试者的精神障碍，或上述疾病的组合的方法。

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