1,18-diphenyloctadecane | 24065-64-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,18-diphenyloctadecane
• 英文别名: 1,18-diphenyl-octadecane；1,18-Diphenyl-octadecan；α,ω-Diphenyloctadecan；1,18-Diphenyloctadecan；18-Phenyloctadecylbenzene
• CAS: 24065-64-3
• 化学式: C₃₀H₄₆
• 分子量: 406.695
• InChiKey: CJICGZZNDFCEKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.6
• 重原子数：
  30
• 可旋转键数：
  19
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  6-碘己酸 在 copper(l) iodide 、 lithium aluminium tetrahydride 、 硫酸 、 氢溴酸 、 甲基锂 、 magnesium 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 为溶剂， 反应 25.0h， 生成 1,18-diphenyloctadecane
  参考文献：
  名称：

  Enantioselective Total Synthesis of Irniine and Bgugaine, Bioactive 2-Alkylpyrrolidine Alkaloids

  摘要：

  An asymmetric total synthesis of the 2-(R)-alkylpyrrolidines, (-)-irniine (1a) and (-)-bgugaine (1b), toxic and antibiotic components of the tubers of Arisarum vulgare, and (+)-(S)-irniine (1c), was carried out by condensation of the corresponding 4-oxoalkanoic acid (9) with chiral phenylglycinol. Acids (9) were prepared from a hetero-organocuprate (I) complex, generated by reaction of methylcopper (I) with alkylmagnesium bromides and methyl chlorocarbonyl-propionate. Alkaloids (1a, 1b and 1c) displayed anti Gram(+) bacterial (MIC 12.5 - 50 mu g/ml) and antifungal (MIC 6.25 - 50 mu g/ml) activities.

  DOI：

  10.3987/com-95-7293

文献信息

• The Prevention of Depressive Symptoms in Children: The Immediate and Long-term Outcomes of a School-based Program
  作者：Clare Pattison、Robert M. Lynd-Stevenson

  DOI：10.1375/bech.18.2.92

  日期：2001.6.1

  The ability of a school-based program with training in both cognitive and social skills to prevent depressive symptoms in children (the Penn Prevention Program) was evaluated. Research conducted in Australia has failed to replicate the success of the program in the United States. Also evaluated was the ability of the program to reduce the symptoms of anxiety, the assumption that changes in social skills and cognitive style would be associated with changes in symptoms of depression and anxiety, and the relative merits of the cognitive and social components of the program. Sixty-three children in fifth and sixth grades were randomly allocated to intervention and control groups. There was no evidence that the Penn Prevention Program had any impact on the variables measured at the end of the program or at the 8-month follow-up assessment. Limitations and implications of the present findings are discussed.

  本研究评估了一个基于学校的项目（宾夕法尼亚预防计划）对儿童抑郁症状的预防效果，该项目对认知和社交技能进行培训。在澳大利亚进行的研究未能复制该项目在美国的成功。同时，还评估了该项目减少焦虑症状的能力，以及社交技能和认知风格的变化是否与抑郁和焦虑症状的变化相关，以及该项目认知和社交组成部分的相对优点。五年级和六年级的63名儿童被随机分配到干预组和对照组。没有证据表明宾夕法尼亚预防计划对项目结束时或8个月随访评估中测量的变量有任何影响。本文讨论了当前发现的局限性和启示。

• Kuck,D.; Gruetzmacher,H.-F., Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1979, vol. 34, p. 1750 - 1764
  作者：Kuck,D.、Gruetzmacher,H.-F.

  DOI：——

  日期：——
• Enantioselective Total Synthesis of Irniine and Bgugaine, Bioactive 2-Alkylpyrrolidine Alkaloids
  作者：Akino Jossang、Ahmed Melhaoui、Bernard Bodo

  DOI：10.3987/com-95-7293

  日期：——

  An asymmetric total synthesis of the 2-(R)-alkylpyrrolidines, (-)-irniine (1a) and (-)-bgugaine (1b), toxic and antibiotic components of the tubers of Arisarum vulgare, and (+)-(S)-irniine (1c), was carried out by condensation of the corresponding 4-oxoalkanoic acid (9) with chiral phenylglycinol. Acids (9) were prepared from a hetero-organocuprate (I) complex, generated by reaction of methylcopper (I) with alkylmagnesium bromides and methyl chlorocarbonyl-propionate. Alkaloids (1a, 1b and 1c) displayed anti Gram(+) bacterial (MIC 12.5 - 50 mu g/ml) and antifungal (MIC 6.25 - 50 mu g/ml) activities.