trideca-3t,5t-diene-7,9,11-triynoic acid | 505-94-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: trideca-3t,5t-diene-7,9,11-triynoic acid
• 英文别名: Trideca-3t,5t-dien-7,9,11-triinsaeure；Isomycomycin (Trideca-3,5-dien-7,9,11-triin-1-saeure)；(3E,5E)-trideca-3,5-dien-7,9,11-triynoic acid
• CAS: 505-94-2
• 化学式: C₁₃H₁₀O₂
• 分子量: 198.221
• InChiKey: HCPADGVIDOCFKJ-BNFZFUHLSA-N

物化性质

• 沸点：
  390.8±44.0 °C(Predicted)
• 密度：
  1.133±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trideca-3t,5t-diene-7,9,11-triynoic acid 在 乙醚 作用下， 生成 (+/-)-3c-hepta-1,3,5-triynyl-6c-methoxycarbonylmethyl-cyclohex-4-ene-1r,2c-dicarboxylic acid-anhydride
  参考文献：
  名称：

  Mycomycin. II. The Structure of Isomycomycin, an Alkali-Isomerization Product of Mycomycin^1,2

  摘要：

  DOI：

  10.1021/ja01135a037
• 作为产物：
  描述：

  戊-1,3-二炔 在 盐酸 、 氢氧化钾 、 ammonium chloride 、 水 、 copper(l) chloride 作用下， 生成 trideca-3t,5t-diene-7,9,11-triynoic acid
  参考文献：
  名称：

  Bohlmann; Viehe, Chemische Berichte, 1954, vol. 87, p. 712,721

  摘要：

  DOI：

文献信息

• FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME
  申请人：KemPharm, Inc.

  公开号：US20170247368A1

  公开（公告）日：2017-08-31

  The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to quetiapine. Pharmaceutical compositions and methods of synthesizing conjugates of the present technology are also provided. Methods of treating patients with the compositions of the present technology are also provided.

  目前所描述的技术提供了一种新型的奎硫平前药类，可以通过将脂肪酸与奎硫平进行化学共轭来合成。同时，还提供了制备本技术共轭物的药物组合物和方法。还提供了使用本技术组合物治疗患者的方法。
• Fibers of variable wettability and materials containing the fibers
  申请人：BUCKEYE TECHNOLOGIES INC.

  公开号：US10300457B2

  公开（公告）日：2019-05-28

  The present invention is directed to an absorbent material and the fibers therein, having two or more layers including an upper surface layer which has on the outer surface of the layer one or more surface area zones which are more wettable zones and adjacent thereto one or more less wettable zones, where the more wettable zones have a greater hydrophilicity than the less wettable zone. The present invention is also directed to the fibers therein, which contain polyvalent cation-containing compounds and fatty acid containing compounds. The present invention also provides for methods of treating fibers or solid materials and processes of producing the hydrophobic materials.

  本发明涉及一种吸水材料及其中的纤维，该材料有两层或多层，包括上表面层，该层的外表面有一个或多个表面积区，这些表面积区是较易润湿区，与其相邻的是一个或多个不易润湿区，其中较易润湿区的亲水性大于不易润湿区。本发明还涉及其中含有多价阳离子化合物和脂肪酸化合物的纤维。本发明还提供了处理纤维或固体材料的方法以及生产疏水材料的工艺。
• FIBERS OF VARIABLE WETTABILITY AND MATERIALS CONTAINING THE FIBERS
  申请人：Buckeye Technologies Inc.

  公开号：EP1696972B1

  公开（公告）日：2016-10-26
• Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same
  申请人：KemPharm, Inc.

  公开号：US20130158007A1

  公开（公告）日：2013-06-20

  The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to quetiapine. Pharmaceutical compositions and methods of synthesizing conjugates of the present technology are also provided. Methods of treating patients with the compositions of the present technology are also provided.
• US8946100B2
  申请人：——

  公开号：US8946100B2

  公开（公告）日：2015-02-03