1-(3-pyridin-3-yl-pyrrolidine-1-yl)propane-1-one | 188196-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(3-pyridin-3-yl-pyrrolidine-1-yl)propane-1-one
• 英文别名: 1-(3-Pyridin-3-ylpyrrolidin-1-yl)propan-1-one；1-(3-pyridin-3-ylpyrrolidin-1-yl)propan-1-one
• CAS: 188196-66-9
• 化学式: C₁₂H₁₆N₂O
• 分子量: 204.272
• InChiKey: GKYQTDCJCVJQSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3-pyridin-3-yl-pyrrolidine-1-yl)propane-1-one 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 2.0h， 以40%的产率得到1-(1-propylpyrrolidin-3-yl)pyridine
  参考文献：
  名称：

  Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity.

  摘要：

  A series of 3-arylpyrrolidines has been synthesised via palladium catalyzed arylation and evaluated for dopaminergic and serotonergic activity in vitro and in vivo. Compounds substituted by electron withdrawing groups on the meta position of the aromatic ring, were found to be preferential dopamine autoreceptor antagonists. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(96)00618-x
• 作为产物：
  描述：

  3-吡啶基三氟甲磺酸酯 在 palladium diacetate 、 palladium on activated charcoal 三(2-呋喃基)膦 、 甲酸铵 、 N,N-二异丙基乙胺 、 lithium chloride 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 1-(3-pyridin-3-yl-pyrrolidine-1-yl)propane-1-one
  参考文献：
  名称：

  Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity.

  摘要：

  A series of 3-arylpyrrolidines has been synthesised via palladium catalyzed arylation and evaluated for dopaminergic and serotonergic activity in vitro and in vivo. Compounds substituted by electron withdrawing groups on the meta position of the aromatic ring, were found to be preferential dopamine autoreceptor antagonists. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(96)00618-x

文献信息

• Novel high affinity thiophene-based and furan-based kinase ligands
  申请人：Deng Yongqi

  公开号：US20070043045A1

  公开（公告）日：2007-02-22

  Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.

  描述了抑制细胞周期依赖性激酶2（CDK-2）的抑制剂、包括这些抑制剂的组合物，以及使用这些抑制剂和抑制剂组合物的方法。这些抑制剂和包括它们的组合物对于治疗疾病或疾病症状是有用的。该发明还提供了制备CDK-2抑制剂化合物的方法、抑制CDK-2的方法，以及治疗疾病或疾病症状的方法。
• US7446195B2
  申请人：——

  公开号：US7446195B2

  公开（公告）日：2008-11-04
• Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity.
  作者：Clas Sonesson、Håkan Wikström、Martin W Smith、Kjell Svensson、Arvid Carlsson、Nicholas Waters

  DOI：10.1016/s0960-894x(96)00618-x

  日期：1997.2

  A series of 3-arylpyrrolidines has been synthesised via palladium catalyzed arylation and evaluated for dopaminergic and serotonergic activity in vitro and in vivo. Compounds substituted by electron withdrawing groups on the meta position of the aromatic ring, were found to be preferential dopamine autoreceptor antagonists. (C) 1997, Elsevier Science Ltd.