2-(methylsulfonyl)ethyl trifluoromethanesulfonate | 126748-92-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 2-(methylsulfonyl)ethyl trifluoromethanesulfonate
• 英文别名: 2-methylsulfonylethyl trifluoromethanesulfonate
• CAS: 126748-92-3
• 化学式: C₄H₇F₃O₅S₂
• 分子量: 256.224
• InChiKey: KMHMNRRZSBJPOX-UHFFFAOYSA-N

物化性质

• 沸点：
  339.7±42.0 °C(Predicted)
• 密度：
  1.607±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  94.3
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4-nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-[7-(pyridin-3-yl)carbonylimidazo[5,1-b]thiazol-2-yl]-1-carbapen-2-em-3-carboxylate 、 2-(methylsulfonyl)ethyl trifluoromethanesulfonate 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and SAR study of novel 7-(pyridinium-3-yl)-carbonyl imidazo[5,1-b]thiazol-2-yl carbapenems

  摘要：

  A new series of 10-methyl carbapenems, possessing a 7-substituted imidazo[5, 1-b]thiazol-2-yl group directly attached to the C-2 position of the carbapenem nucleus, was synthesized and evaluated for antibacterial activity. These compounds showed potent activities against Gram-positive bacteria, in particular methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae (PRSP). They also exhibited potent activity against beta-lactamase-negative ampicillin-resistant Haemophilus influenzae (BLNAR). (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.09.049
• 作为产物：
  描述：

  2-羟乙基甲砜 、 三氟甲磺酸酐 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 2-(methylsulfonyl)ethyl trifluoromethanesulfonate
  参考文献：
  名称：

  Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 4. Effect of various side-chain substituents on therapeutic activity against anticholinesterase intoxication

  摘要：

  A series of quaternary salt derivatives of 2-[(hydroxyimino)methyl]-1-methylimidazole incorporating various side chains bearing ether, silyl, nitrile, ester, halogen, nitro, sulfone, amino, or aminosulfonyl substituents was prepared and evaluated in vivo for the treatment of anticholinesterase intoxication. Test results in the mouse revealed that the type and location of the side-chain substituent both have a significant influence on the toxicity and antidotal effectiveness of the compounds. Some of the more active examples represent the most potent therapeutics to date against intoxication by the powerful cholinesterase inhibitors soman and tabun. Significantly, the antidotal effectiveness of the compounds was not dependent on the inhibiting agent nor was there any correlation between in vivo efficacy and in vitro reactivation of ethyl (4-nitrophenyl)methylphosphonate inhibited human acetylcholinesterase. These observations suggested that the main mode of antidotal protection by the compounds is something other than enzyme reactivation.

  DOI：

  10.1021/jm00108a019

文献信息

• Aldoxime-substituted triazolium compounds useful in the treatment of
  申请人：SRI International

  公开号：US04865837A1

  公开（公告）日：1989-09-12

  A therapeutically effective class of low toxicity aldoxime-substituted trazolium derivatives is disclosed which is effective in the treatment of living species poisoned by organophosphorus chemicals which inactivate the enzyme acetylcholinesterase. In vivo administration of therapeutically effective amounts of these low toxicity aldoxime-substituted triazolium derivatives has been found to save mice having inhibited acetylcholinesterase due to injection with lethal dosages of Soman.

  本发明揭示了一类治疗有效、低毒性的醛肟取代三唑盐衍生物，其对被有机磷化学品中毒的生物具有治疗作用，这些化学品会使乙酰胆碱酯酶失活。已经发现，在体内给予这些低毒性的醛肟取代三唑盐衍生物的治疗有效量，可以拯救因注射致命剂量的索曼而导致乙酰胆碱酯酶受抑制的小鼠。
• GOFF, DANE A.;KOOLPE, GARY A.;KELSON, ANDREW B.;VU, HUYNH M.;TAYLOR, DORR+, J. MED. CHEM., 34,(1991) N, C. 1363-1366
  作者：GOFF, DANE A.、KOOLPE, GARY A.、KELSON, ANDREW B.、VU, HUYNH M.、TAYLOR, DORR+

  DOI：——

  日期：——