ammonia, caproic acid | 32582-93-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ammonia, caproic acid
• 英文别名: Azane;hexanoic acid
• CAS: 32582-93-7
• 化学式: C₆H₁₂O₂*H₃N
• 分子量: 133.191
• InChiKey: JTSVYBPWSSQBEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.69
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  41.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ammonia, caproic acid 在 octanedioic acid ; neutral ammonium salt 作用下， 19.9 ℃ 、7999.96 MPa 条件下， 以10.0%的产率得到己酰胺
  参考文献：
  名称：

  Study of the reactivity of ammonium carboxylates in the synthesis of amides under high-pressure deformation conditions

  摘要：

  DOI：

  10.1007/bf00962116

文献信息

• PROCESSES FOR PREPARING ANTIVIRAL COMPOUNDS
  申请人：Gilead Pharmasset LLC

  公开号：US20150361073A1

  公开（公告）日：2015-12-17

  The present disclosure provides processes for the preparation of a compound of formula: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates.

  本公开提供了制备一种化合物的方法，该化合物的化学式如下所示：该化合物可用作抗病毒药物。本公开还提供了合成中间体化合物。
• [EN] PROCESSES FOR PREPARING ANTIVIRAL COMPOUNDS<br/>[FR] PROCÉDÉS DE PRÉPARATION DE COMPOSÉS ANTIVIRAUX
  申请人：GILEAD PHARMASSET LLC

  公开号：WO2015191437A1

  公开（公告）日：2015-12-17

  The present disclosure provides processes for the preparation of a compound of formula: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates.

  本披露提供了一种制备式为的化合物的过程：它可用作抗病毒剂。该披露还提供了合成中间体化合物。
• Storage stable topical pharmaceutical compositions containing zinc erythromycin and t-butanol
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0109103A2

  公开（公告）日：1984-05-23

  A storage stable topical pharmaceutical composition containing zinc erythromycin, particularly useful in the topical treatment of acne vulgaris, is disclosed. This composition contains a solvent having a dielectric constant, measured at 25°C, of from about 5.5 to about 15, preferably from about 8 to about 12. such as t-butanol, to impart storage stability to the zinc erythromycin component. The composition may additonally contain particularly selected pharmaceutically-acceptable ni- trogencontaining stabilizer components, such as diisopropanolamine.

  本发明公开了一种含有红霉素锌的贮存稳定的外用药物组合物，尤其适用于寻常痤疮的外用治疗。该组合物含有一种溶剂，其介电常数（在 25°C 时测量）约为 5.5 至 15，优选约为 8 至 12，如叔丁醇，以赋予红霉素锌成分储存稳定性。该组合物还可添加特别选定的药学上可接受的含氮稳定剂成分，如二异丙醇胺。
• Linear salicylic acid copolymers and their metal salts, production process thereof, color-developing agents comprising metal-resins of the copolymers, and color-developing sheets employing the agents
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0233450A2

  公开（公告）日：1987-08-26

  Disclosed herein are novel linear copolymers having weight average molecular weight of 500 - 30,000 and comprising structural units represented by the following formulae (I), (II), (III) and (IV): wherein R₁, R₂ and R₃ mean individually an alkyl group having 4 or fewer carbon atoms and R₄ denotes an alkyl, cycloalkyl, aralkyl or phenyl group, and multivalent metal salts thereof in each of which the multivalent metal forms the multivalent metal salt between carboxyl groups within the same molecule of the copolymer or between different molecules of the copolymer; color-­developing agents comprising multivalent metal-modified resins of the copolymers; and color-developing sheets obtained by coating the color-developing agents on their surfaces.

  本文公开了新型线性共聚物，其重量平均分子量为 500 - 30,000，包含下式 (I)、(II)、(III) 和 (IV) 所代表的结构单元： 其中 R₁、R₂ 和 R₃ 分别表示具有 4 个或更少碳原子的烷基，R₄ 表示烷基、环烷基、芳烷基或苯基，以及多价金属盐，其中多价金属在共聚物的同一分子内或共聚物的不同分子间的羧基之间形成多价金属盐；由共聚物的多价金属改性树脂组成的显色剂；以及通过在其表面涂布显色剂而获得的显色薄片。
• Salicylic acid copolymers and their metal salts, production process thereof, color-developing agents comprising metal salts of the copolymers and color-developing sheets employing the agents
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0268878A2

  公开（公告）日：1988-06-01

  Disclosed herein are salicylic acid copolymers having a weight average molecular weight of 500 10,000 and obtained (a) by condensing salicylic acid (i) with a benzyl alcohol (ii) and/or benzyl ether (iii) or a benzyl halide (iv) in the presence of an acid catalyst or (b) by reacting a co-condensation resin of (i) and (ii) and/or (iii) with (iv) or (c) by reacting a co-condensation resin of (i) and (ii) and/or (iii) or (iv) with a styrene derivative in the presence of an acid catalyst; multivalent metal salts of the salicylic acid copolymers; color-developing agents comprising the multivalent metal salts; and color-developing sheets suited for pressure-sensitive copying paper and comprising the color-developing agents. Their production processes are also disclosed.

  本文公开了水杨酸共聚物，其重量平均分子量为 500 10、000 的水杨酸共聚物；(a)在酸催化剂存在下，将水杨酸(i)与苄醇(ii)和/或苄醚(iii)或苄基卤化物(iv)缩合而得，或(b)将(i)和(ii)和/或(iii)的共缩合树脂与(iv)反应而得，或(c)在酸催化剂存在下，将(i)和(ii)和/或(iii)或(iv)的共缩合树脂与苯乙烯衍生物反应而得；水杨酸共聚物的多价金属盐；由多价金属盐组成的显色剂；以及由显色剂组成的适用于压敏复印纸的显色薄片。此外，还公开了它们的生产工艺。