dibenzyl methylphosphonite | 126864-56-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dibenzyl methylphosphonite
• 英文别名: Methyl-bis(phenylmethoxy)phosphane
• CAS: 126864-56-0
• 化学式: C₁₅H₁₇O₂P
• 分子量: 260.273
• InChiKey: KGRNPJHKAPAQLF-UHFFFAOYSA-N

物化性质

• 沸点：
  360.7±35.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dibenzyl methylphosphonite 在 selenium 作用下， 生成 dibenzyl methaneselenophosphonate
  参考文献：
  名称：

  Direct α-chlorination of O,O -dialkyl chalcogenophosphonates with phosphorus oxychloride

  摘要：

  alpha -Chlorination of phosphonates, and O,O-dialkyl thio- and selenophosphonates involving the direct reaction of their lithiated anion with phosphorus oxychloride is described. The reaction gives good results where previously known methods fail. The role of the chalcogen atom, and the influence of the nature of the alkyl chain with respect to the reactivity are discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01382-x
• 作为产物：
  描述：

  甲基二氯膦 、 苯甲醇 在 N,N-二乙基苯胺 作用下， 以 乙醚 为溶剂， 反应 2.0h， 以44%的产率得到dibenzyl methylphosphonite
  参考文献：
  名称：

  天冬氨酸的氨基膦酸和氨基次膦酸类似物

  摘要：

  将4-乙酰氧基氮杂环丁烷-2-酮和4α-乙酰氧基-3β-邻苯二甲酰亚胺-2-酮与各种亚磷酸酯和亚膦酸酯的Arbusov反应制得的4-氧杂氮杂环丁烷-2-基膦酸酯和次膦酸酯被水解为β-膦酸酯基和亚膦酸酯基。 β-膦基β-丙氨酸（膦酸和膦天冬氨酸）衍生物。在将其掺入肽的模型研究中，研究了选择性除去衍生的二肽和三肽中的羧酸，膦酸和次膦酸以及胺的保护基的条件。研究了丙氨酰和丙氨酰丙氨酰肽掺入细菌的过程。

  DOI：

  10.1016/0040-4020(82)85087-4

文献信息

• Aminophosphonic and aminophosphinic acid analogues of aspartic acid
  作者：Malcolm M. Campbell、Nicholas I. Carruthers、Stuart J. Mickel

  DOI：10.1016/0040-4020(82)85087-4

  日期：1982.1

  obtained from Arbusov reactions of 4-acetoxyazetidin-2-one and 4α-acetoxy-3β-phthalimido-2-one with a variety of phosphites and phosphonites, were hyrdolysed to β-phosphono- and β-phosphino β-alanine (phosphono- and phosphinoaspartic acid) derivatives. In model studies for their incorporation in peptides, conditions for the selective removal of protecting groups for carboxylic acids, phosphonic and phosphinic

  将4-乙酰氧基氮杂环丁烷-2-酮和4α-乙酰氧基-3β-邻苯二甲酰亚胺-2-酮与各种亚磷酸酯和亚膦酸酯的Arbusov反应制得的4-氧杂氮杂环丁烷-2-基膦酸酯和次膦酸酯被水解为β-膦酸酯基和亚膦酸酯基。 β-膦基β-丙氨酸（膦酸和膦天冬氨酸）衍生物。在将其掺入肽的模型研究中，研究了选择性除去衍生的二肽和三肽中的羧酸，膦酸和次膦酸以及胺的保护基的条件。研究了丙氨酰和丙氨酰丙氨酰肽掺入细菌的过程。
• Prodrugs of modulators of ABC transporters
  申请人：Grootenhuis Peter D.J.

  公开号：US20090105272A1

  公开（公告）日：2009-04-23

  The present invention relates to prodrugs of modulators of ABC transporters, particularly, CFTR modulators, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

  本发明涉及ABC转运蛋白调节剂的前药，特别是CFTR调节剂，以及其组成物和使用这些调节剂的方法。本发明还涉及使用这些调节剂治疗ABC转运蛋白介导的疾病的方法。
• Miscible high Tg polyester/polymer blend compositions and films formed therefrom
  申请人：Hale Raymond Wesley

  公开号：US20060270806A1

  公开（公告）日：2006-11-30

  Disclosed is a high Tg polyester/polymer blend composition for a sheet or film. The composition comprises about 80 to about 99.8 percent by weight of a miscible blend of a polyester with a polymer. Also disclosed is a process for the preparation of a film or sheet from this composition. Compensationa and protective films and sheets prepared from this composition are useful for backlight displays.

  本发明公开了一种用于制作薄膜或薄片的高Tg聚酯/聚合物混合物组合物。该组合物由聚酯和聚合物的可混合混合物约占重量的80％至约99.8％组成。本发明还公开了从该组合物制备薄膜或薄片的过程。使用该组合物制备的补偿和保护膜和薄片适用于背光显示。
• Certain polyester compositions which comprise cyclohexanedimethanol, moderate cyclobutanediol, cyclohexanedimethanol, and high trans cyclohexanedicarboxylic acid
  申请人：Moody Leslie Shane

  公开号：US20070232779A1

  公开（公告）日：2007-10-04

  Described as one aspect of the invention are polyester compositions A polyester composition comprising at least one polyester which comprises: (A) a dicarboxylic acid component comprising: i) 70 to 100 mole % of cyclohexanedicarboxylic acid residues or an ester thereof comprising: (a) 80 to 99 mole % trans-cyclohexanedicarboxylic acid residues or an ester thereof; and (b) 1 to 20 mole % cis-cyclohexanedicarboxylic acid residues or an ester thereof; ii) 0 to 30 mole % of aliphatic dicarboxylic acid residues, other than cyclohexanedicarboxylic acid residues, having up to 16 carbon atoms or esters thereof, other than cyclohexanedicarboxylic acid residues; and iii) 0 to 10 mole % of aromatic dicarboxylic acid residues having up to 20 carbon atoms; and (B) a glycol component comprising: i) 5 to 35 mole % of 2,2,4,4-tetramethyl-1,3-cyclobutanediol residues; and ii) 65 to 95 mole % of 1,4-cyclohexanedimethanol residues, 1,3-cyclohexanedimethanol residues, 1,2-cyclohexanedimethanol residues or esters thereof or mixtures thereof, wherein the total mole % of said dicarboxylic acid component is equal to 100 mole %; the total mole % of said glycol component is equal to 100 mole %; wherein the inherent viscosity of said polyester is from 0.35 to 1.2 dL/g as determined in 60/40 (wt/wt) phenol/tetrachloroethane at a concentration of 0.5 g/100 ml at 25° C.; and wherein said polyester has a Tg of from 66 to 120° C. The polyesters may be manufactured into articles.

  本发明的一方面是聚酯组合物，其中包括至少一种聚酯，该聚酯包括：(A) 二羧酸组分，包括：i) 70至100摩尔％的环己二甲酸残基或其酯，包括：(a) 80至99摩尔％的反式环己二甲酸残基或其酯；和(b) 1至20摩尔％的顺式环己二甲酸残基或其酯；ii) 0至30摩尔％的具有高达16个碳原子的脂肪族二羧酸残基（环己二甲酸残基除外）或其酯；以及iii) 0至10摩尔％的具有高达20个碳原子的芳香族二羧酸残基；和(B) 二元醇组分，包括：i) 5至35摩尔％的2,2,4,4-四甲基-1,3-环丁二醇残基；和ii) 65至95摩尔％的1,4-环己二甲醇残基，1,3-环己二甲醇残基，1,2-环己二甲醇残基或其酯或其混合物，其中所述二羧酸组分的总摩尔％等于100摩尔％；所述二元醇组分的总摩尔％等于100摩尔％；其中所述聚酯的固有粘度在60/40（重量/重量）苯酚/四氯乙烷中以0.5 g / 100 ml浓度在25°C下测定为0.35至1.2 dL / g；且所述聚酯的Tg在66至120°C之间。这些聚酯可以制成物品。
• Certain polyester compositions which comprise cyclobutanediol, cyclohexanedimethanol, and high trans-cyclohexanedicarboxylic acid
  申请人：Moody Leslie Shane

  公开号：US20070232778A1

  公开（公告）日：2007-10-04

  Described as one aspect of the invention are polyester compositions comprising at least one polyester which comprises: (A) a dicarboxylic acid component comprising: i) 70 to 100 mole % of cyclohexanedicarboxylic acid residues or an ester thereof comprising: (a) 70 to 98 mole % trans-cyclohexanedicarboxylic acid residues or an ester thereof; and (b) 2 to 30 mole % cis-cyclohexanedicarboxylic acid residues or an ester thereof; ii) 0 to 30 mole % of aliphatic dicarboxylic acid residues, other than cyclohexanedicarboxylic acid residues, having up to 16 carbon atoms or esters thereof, other than cyclohexanedicarboxylic acid residues,; and iii) 0 to 10 mole % of aromatic dicarboxylic acid residues having up to 20 carbon atoms; and (B) a glycol component comprising: i) 1 to 99 mole % of 2,2,4,4-tetramethyl-1,3-cyclobutanediol residues; and ii) 1 to 99 mole % of 1,4-cyclohexanedimethanol residues, 1,3-cyclohexanedimethanol residues, 1,2-cyclohexanedimethanol residues or esters thereof or mixtures thereof, wherein the total mole % of said dicarboxylic acid component is equal to 100 mole %; the total mole % of said glycol component is equal to 100 mole %; wherein the inherent viscosity of said polyester is from 0.35 to 1.2 dL/g as determined in 60/40 (wt/wt) phenol/tetrachloroethane at a concentration of 0.5 g/100 ml at 25° C.; and wherein said polyester has a Tg of from 60 to 155° C. The polyesters may be manufactured into articles.

  本发明的一方面是聚酯组合物，包括至少一种聚酯，其包括：（A）二羧酸成分，包括：i）70至100摩尔％的环己烷二羧酸残基或其酯，包括：（a）70至98摩尔％的反式环己烷二羧酸残基或其酯；和（b）2至30摩尔％的顺式环己烷二羧酸残基或其酯；ii）0至30摩尔％的脂肪族二羧酸残基，除了具有高达16个碳原子的环己烷二羧酸残基或其酯之外；和iii）0至10摩尔％的具有高达20个碳原子的芳香族二羧酸残基；以及（B）乙二醇成分，包括：i）2,2,4,4-四甲基-1,3-环丁二醇残基的1至99摩尔％；和ii）1,4-环己二甲醇残基、1,3-环己二甲醇残基、1,2-环己二甲醇残基或其酯或其混合物的1至99摩尔％；其中，所述二羧酸成分的总摩尔％等于100摩尔％；所述乙二醇成分的总摩尔％等于100摩尔％；其中，所述聚酯的固有粘度为0.35至1.2 dL/g，在60/40（重量/重量）苯酚/四氯乙烷中，在25°C下浓度为0.5 g/100 ml时确定；所述聚酯具有从60°C到155°C的Tg。这些聚酯可以制成物品。