3-Amino-4,5-dimethylthiazolium mesitylenesulfonate | 181070-74-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Amino-4,5-dimethylthiazolium mesitylenesulfonate
• 英文别名: 4,5-dimethyl-1,3-thiazol-3-ium-3-amine;2,4,6-trimethylbenzenesulfonate
• CAS: 181070-74-6
• 化学式: C₅H₉N₂S*C₉H₁₁O₃S
• 分子量: 328.456
• InChiKey: BLYJGWZLANJOIF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.88
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  124
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4,5-二甲基噻唑 、 2,4,6-三甲基苯磺酰羟胺 以 二氯甲烷 为溶剂， 生成 3-Amino-4,5-dimethylthiazolium mesitylenesulfonate
  参考文献：
  名称：

  Methods of Treating or Preventing Cardiac Disease Associated With a High Fat Diet

  摘要：

  本发明涉及一种使用该发明的噻唑类化合物和组合物治疗或预防与高脂饮食相关的心脏疾病、心肌炎症或心肌氧化应激的方法。本发明还涉及一种使用该发明的噻唑类化合物和组合物改善与高脂饮食相关的体重增加、心肌AGE积累、线粒体超氧化物产生、RAGE表达或PPARα表达的方法。

  公开号：

  US20090088461A1
• 作为试剂：
  描述：

  、 4,5-二甲基噻唑 、 N-羟基-2,4,6-三甲基苯磺酰胺 、 乙醚 在 title product 、 3-Amino-4,5-dimethylthiazolium mesitylenesulfonate 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 3-Amino-4,5-dimethylthiazolium mesitylenesulfonate
  参考文献：
  名称：

  Preventing and reversing the formation of advance glycosylation endproducts

  摘要：

  本发明涉及用于抑制和逆转非酶促交联（蛋白老化）的组合物和方法。因此，披露了包含一种能够抑制目标蛋白质的高级糖基化终产物的形成的药剂的组合物，并且通过裂解在高级糖基化终产物中存在的α-二羰基基础蛋白交联来逆转预先形成的交联。某些有用的药剂是噻唑盐。该方法包括将目标蛋白质与该组合物接触。该发明既可以在工业上应用，也可以在治疗上应用，因为可以治疗食品变质和动物蛋白质老化。还披露了一种新型的免疫测定方法，用于检测非酶促交联的逆转。

  公开号：

  US20070025926A1

文献信息

• Preventing and reversing the formation of advanced glycosylation
  申请人：The Picower Institute for Medical Research

  公开号：US05853703A1

  公开（公告）日：1998-12-29

  The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

  本发明涉及用于抑制和逆转非酶交联（蛋白老化）的组合物和方法。因此，揭示了包括一种能够抑制靶蛋白的高级糖基化终产物形成的药剂的组合物，并且通过裂解存在于高级糖基化终产物中的α-二酮基蛋白交联，进一步逆转了预先形成的交联。某些有用的药剂是噻唑盐。该方法包括将目标蛋白与该组合物接触。本发明预见了工业和治疗应用，因为可以治疗食品变质和动物蛋白质老化。还揭示了一种用于检测非酶交联逆转的新型免疫测定法。
• Preventing and reversing advanced glycosylation endproducts
  申请人：The Picower Institute for Medical Research

  公开号：US05656261A1

  公开（公告）日：1997-08-12

  The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a thiazolium compound capable of inhibiting, and to some extent reversing, the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

  本发明涉及用于抑制和逆转非酶交联（蛋白老化）的组合物和方法。因此，公开了一种组合物，包括一种噻唑化合物，能够抑制，并在一定程度上逆转，通过与目标蛋白的早期糖基化产物的羰基部分发生反应，从而阻止目标蛋白形成高级糖基化终产物。该方法包括将目标蛋白与该组合物接触。该发明可用于工业和治疗应用，因为可以处理食品腐败和动物蛋白质老化。还公开了一种用于检测非酶交联逆转的新型免疫分析方法。
• Method of treating certain indications associated with hyperglycemia
  申请人：——

  公开号：US20020192842A1

  公开（公告）日：2002-12-19

  The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

  本发明涉及用于抑制和逆转非酶促交联（蛋白质老化）的组合物和方法。因此，揭示了包括一种能够抑制目标蛋白质高级糖基化终产物的生成的药剂的组合物，并且通过断裂高级糖基化终产物中存在的基于α-二羰基的蛋白质交联物来逆转预先形成的交联。某些有用的药剂是噻唑盐。该方法包括将组合物与目标蛋白质接触。预计该发明具有工业和治疗应用，因为可以处理食品变质和动物蛋白质老化。还揭示了一种用于检测非酶促交联逆转的新型免疫测定法。
• Reversing the formation of advanced glycosylation endproducts
  申请人：Alteon Inc.

  公开号：US06007865A1

  公开（公告）日：1999-12-28

  The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

  本发明涉及用于抑制和逆转非酶促交联（蛋白质老化）的组合物和方法。因此，披露了包括能够抑制目标蛋白质的高级糖基化终产物的形成的药剂的组合物，并且通过裂解存在于高级糖基化终产物中的α-二羰基基础蛋白交联物来逆转预先形成的交联物。某些有用的药剂是噻唑盐。该方法包括将组合物与目标蛋白质接触。预见到该发明在工业和治疗应用中都有用途，因为可以处理食品变质和动物蛋白质老化。还披露了一种新的免疫测定法，用于检测非酶促交联逆转的情况。
• Use of thiazolium compounds for preventing and reversing the formation of advanced glycosylation end products
  申请人：Alteon, Inc.

  公开号：EP1327887A2

  公开（公告）日：2003-07-16

  The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

  本发明涉及抑制和逆转非酶交联（蛋白质老化）的组合物和方法。因此，本发明公开了包含能够抑制目标蛋白质晚期糖基化终产物形成的制剂的组合物，以及通过裂解晚期糖基化终产物中存在的基于α-二羰基的蛋白质交联，逆转晚期糖基化终产物中预先形成的交联的组合物。某些有用的制剂是噻唑盐。该方法包括将目标蛋白质与组合物接触。本发明既可用于工业，也可用于治疗，因为食品变质和动物蛋白老化都可以得到治疗。本发明还公开了一种检测非酶交联逆转的新型免疫测定法。