[4-[hydroxy(phenyl)methyl]-3,4-dihydro-2H-pyridin-1-yl]-(4-methoxyphenyl)methanone | 1073151-31-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-[hydroxy(phenyl)methyl]-3,4-dihydro-2H-pyridin-1-yl]-(4-methoxyphenyl)methanone
• CAS: 1073151-31-1
• 化学式: C₂₀H₂₁NO₃
• 分子量: 323.392
• InChiKey: KUOADUDMMRTMED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  [1-(4-methoxybenzoyl)-3,4-dihydro-2H-pyridin-4-yl] acetate 、 苯甲醛 在 diethylzinc 、 palladium diacetate 、 三苯基膦 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 2.0h， 以93%的产率得到[4-[hydroxy(phenyl)methyl]-3,4-dihydro-2H-pyridin-1-yl]-(4-methoxyphenyl)methanone
  参考文献：
  名称：

  Regioselective Introduction of Electrophiles into Piperidine Derivatives at the 4-Position

  摘要：

  Regioselective introduction of various electrophiles (aldehydes, ketones, and imines) into piperidine skeleton at the 4-position was achieved with a catalytic amount of Pd(OAc)(2)/PPh3 in the presence of excess Et2Zn. In addition, enantioselective introduction of benzaldehyde into piperidine derivatives was accomplished by using chiral phosphine ligand with moderate enantioselectivity.

  DOI：

  10.3987/com-08-s(n)26

文献信息

• Regioselective Introduction of Electrophiles into Piperidine Derivatives at the 4-Position
  作者：Osamu Onomura、Noriyuki Fujimura、Takahisa Oda、Yoshihiro Matsumura、Yosuke Demizu

  DOI：10.3987/com-08-s(n)26

  日期：——

  Regioselective introduction of various electrophiles (aldehydes, ketones, and imines) into piperidine skeleton at the 4-position was achieved with a catalytic amount of Pd(OAc)(2)/PPh3 in the presence of excess Et2Zn. In addition, enantioselective introduction of benzaldehyde into piperidine derivatives was accomplished by using chiral phosphine ligand with moderate enantioselectivity.