19-{[tert-Butyl(dimethyl)silyl]oxy}-3-methylnonadec-1-en-3-ol | 824404-34-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 19-{[tert-Butyl(dimethyl)silyl]oxy}-3-methylnonadec-1-en-3-ol
• 英文别名: 19-[tert-butyl(dimethyl)silyl]oxy-3-methylnonadec-1-en-3-ol
• CAS: 824404-34-4
• 化学式: C₂₆H₅₄O₂Si
• 分子量: 426.799
• InChiKey: JQFPQWQENWVCMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  29
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  三甲基氢醌 、 19-{[tert-Butyl(dimethyl)silyl]oxy}-3-methylnonadec-1-en-3-ol 在 三氯化铝 作用下， 以 硝基甲烷 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 2-(16-Hydroxyhexadecyl)-2,5,7,8-tetramethyl-3,4-dihydrochromen-6-ol
  参考文献：
  名称：

  Tocopherol long chain fatty alcohols decrease the production of TNF-α and NO radicals by activated microglial cells

  摘要：

  The synthesis of a series of Tocopherol long chain Fatty Alcohols (TEA) and their biological activities on the modulation of microglial activation are described. Specifically, the 2-(12-hydroxy-dodecyl)-2,5,7,8-tetramethyl-chroman-6-ol, the TEA bearing 12 carbon atoms on the side chain (n = 12), shows the most potent inhibition of secretion on nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) by lipopolysaccharide (LPS)-activated microglia. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.078
• 作为产物：
  描述：

  16-碘十六烷-1-醇 在 咪唑 、 叔丁基锂 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 3.33h， 生成 19-{[tert-Butyl(dimethyl)silyl]oxy}-3-methylnonadec-1-en-3-ol
  参考文献：
  名称：

  Tocopherol long chain fatty alcohols decrease the production of TNF-α and NO radicals by activated microglial cells

  摘要：

  The synthesis of a series of Tocopherol long chain Fatty Alcohols (TEA) and their biological activities on the modulation of microglial activation are described. Specifically, the 2-(12-hydroxy-dodecyl)-2,5,7,8-tetramethyl-chroman-6-ol, the TEA bearing 12 carbon atoms on the side chain (n = 12), shows the most potent inhibition of secretion on nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) by lipopolysaccharide (LPS)-activated microglia. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.078

文献信息

• Tocopherol long chain fatty alcohols decrease the production of TNF-α and NO radicals by activated microglial cells
  作者：Thierry Muller、Luc Grandbarbe、Eleonora Morga、Paul Heuschling、Bang Luu

  DOI：10.1016/j.bmcl.2004.09.078

  日期：2004.12

  The synthesis of a series of Tocopherol long chain Fatty Alcohols (TEA) and their biological activities on the modulation of microglial activation are described. Specifically, the 2-(12-hydroxy-dodecyl)-2,5,7,8-tetramethyl-chroman-6-ol, the TEA bearing 12 carbon atoms on the side chain (n = 12), shows the most potent inhibition of secretion on nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) by lipopolysaccharide (LPS)-activated microglia. (C) 2004 Elsevier Ltd. All rights reserved.