2,2,2-trichloroethyl N-(3-methylbut-2-enyl)-N-sulfamoyloxycarbamate | 1310054-26-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: 2,2,2-trichloroethyl N-(3-methylbut-2-enyl)-N-sulfamoyloxycarbamate
• CAS: 1310054-26-2
• 化学式: C₈H₁₃Cl₃N₂O₅S
• 分子量: 355.627
• InChiKey: MDTTYIPMENLOOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,2,2-trichloroethyl N-(3-methylbut-2-enyl)-N-sulfamoyloxycarbamate 在 bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} 、 碘苯二乙酸 、 magnesium oxide 作用下， 以 醋酸异丙酯 为溶剂， 反应 4.0h， 以82%的产率得到2,2,2-Trichloroethyl 7,7-dimethyl-2,2-dioxo-3-oxa-2lambda6-thia-1,4-diazabicyclo[4.1.0]heptane-4-carboxylate
  参考文献：
  名称：

  Synthesis and Reactivity of Unique Heterocyclic Structures en Route to Substituted Diamines

  摘要：

  Rhodium-catalyzed oxidative cyclization of allylic hydroxylamine-derived sulfamate esters furnishes a novel family of bicyclic aziridines that serve as functional precursors to substituted diamines. Investigations with the N4-Troc form of these heterocycles have led to manifold improvements in reaction performance and scope and have revealed unique differences in the stability and reactivity of such compounds dictated by the choice of N4-protecting group.

  DOI：

  10.1021/ol2010769
• 作为产物：
  描述：

  TrocNHOSO2NH2 、 异戊烯醇 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 以100%的产率得到2,2,2-trichloroethyl N-(3-methylbut-2-enyl)-N-sulfamoyloxycarbamate
  参考文献：
  名称：

  Synthesis and Reactivity of Unique Heterocyclic Structures en Route to Substituted Diamines

  摘要：

  Rhodium-catalyzed oxidative cyclization of allylic hydroxylamine-derived sulfamate esters furnishes a novel family of bicyclic aziridines that serve as functional precursors to substituted diamines. Investigations with the N4-Troc form of these heterocycles have led to manifold improvements in reaction performance and scope and have revealed unique differences in the stability and reactivity of such compounds dictated by the choice of N4-protecting group.

  DOI：

  10.1021/ol2010769

文献信息

• Synthesis and Reactivity of Unique Heterocyclic Structures en Route to Substituted Diamines
  作者：David E. Olson、Autumn Maruniak、Sushant Malhotra、Barry M. Trost、J. Du Bois

  DOI：10.1021/ol2010769

  日期：2011.7.1

  Rhodium-catalyzed oxidative cyclization of allylic hydroxylamine-derived sulfamate esters furnishes a novel family of bicyclic aziridines that serve as functional precursors to substituted diamines. Investigations with the N4-Troc form of these heterocycles have led to manifold improvements in reaction performance and scope and have revealed unique differences in the stability and reactivity of such compounds dictated by the choice of N4-protecting group.