5-(dodecyloxycarbonyl)pentylammonium 5-(dodecyloxycarbonyl)pentylcarbamate | 214047-02-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-(dodecyloxycarbonyl)pentylammonium 5-(dodecyloxycarbonyl)pentylcarbamate
• 英文别名: transkarbam 12；6-Dodecyloxy-6-oxohexylammonium 6-dodecyloxy-6-oxohexylcarbamate；(6-dodecoxy-6-oxohexyl)azanium;N-(6-dodecoxy-6-oxohexyl)carbamate
• CAS: 214047-02-6
• 化学式: C₁₈H₃₇NO₂*C₁₉H₃₇NO₄
• 分子量: 643.004
• InChiKey: WAKSYWSFPNDJLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.25
• 重原子数：
  45
• 可旋转键数：
  35
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  128
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  二氧化碳 、 十二烷基6-氨基己酸酯 以 乙醚 为溶剂， 反应 0.5h， 以89%的产率得到5-(dodecyloxycarbonyl)pentylammonium 5-(dodecyloxycarbonyl)pentylcarbamate
  参考文献：
  名称：

  Synthesis and Enhancing Effect of Transkarbam 12 on the Transdermal Delivery of Theophylline, Clotrimazole, Flobufen, and Griseofulvin

  摘要：

  十二烷基-6-氨基己酸酯（DDEAC）是一种具有优良活性、低毒性且无皮肤刺激的经皮渗透增强剂。我们假设DDEAC与空气中的二氧化碳发生反应，形成一种双链铵盐氨基甲酸酯——Transkarbam 12（T12），这是其增强效果的原因。我们合成了DDEAC和T12，并通过光谱方法确认了它们的结构；同时，利用Franz扩散池和人皮肤研究了它们的增强活性。我们开发了一种高效液相色谱法来测定T12的含量，并使用猪酯酶评估其生物降解性。只有氨基甲酸盐T12对高增强活性负责；在氩气环境下测试DDEAC以避免与二氧化碳反应时，其活性无效。T12能够增强多种药物的经皮渗透，涵盖了广泛的物理化学特性，包括茶碱（增强比率高达55.6）、克霉唑（7.7）、氟必利（5.0）和灰黄霉素（24）。其活性依赖于pH值，进一步确认了氨基甲酸酯结构的重要性。T12的代谢遵循二级动力学，半衰期为31分钟。这些结果表明，T12是一个有前景的生物可降解渗透增强剂，适用于多种药物，而这种结构新颖的氨基甲酸酯增强剂值得进一步研究。

  DOI：

  10.1007/s11095-006-9782-y

文献信息

• Transkarbams as transdermal permeation enhancers: Effects of ester position and ammonium carbamate formation
  作者：Michal Novotný、Alexandr Hrabálek、Barbora Janůšová、Jakub Novotný、Kateřina Vávrová

  DOI：10.1016/j.bmcl.2010.03.077

  日期：2010.5

  Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6-aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as well, and its activity highly depends on the position of the ester group. (C) 2010 Elsevier Ltd. All rights reserved.
• OMEGA-AMINO ACID DERIVATIVES, PROCESSES OF THEIR PREPARATION AND THEIR USE
  申请人：Biochemie S.R.O.

  公开号：EP0973710A2

  公开（公告）日：2000-01-26
• VASODILATOR FORMULATION AND METHOD OF USE
  申请人：Atp Institute Pty Ltd.

  公开号：EP3065730B1

  公开（公告）日：2019-12-25
• TRANSDERMAL APPLICATION OF TRIAZINES FOR CONTROLLING INFECTIONS WITH COCCIDIA
  申请人：Heep Iris

  公开号：US20100179151A1

  公开（公告）日：2010-07-15

  The present invention relates to the transdermal application of triazines such as toltrazuril or ponazuril for controlling infections with coccidia in humans and animals.
• Transdermal Pharmaceutical Compositions Including Testosterone and a C-SERM
  申请人：Professional Compounding Centers of America (PCCA)

  公开号：US20160051498A1

  公开（公告）日：2016-02-25

  Formulations for transdermal pharmaceutical compositions including a synergistic combination of low doses of testosterone with a selective estrogen receptor modulator (C-SERM) that are combined with transdermal permeation enhancers are disclosed. Transdermal pharmaceutical compositions can be designed with various release rates, and can be administered to increase bloodstream testosterone levels and thereby reduce symptoms of testosterone deficiency. Transdermal pharmaceutical compositions include liquid dosage forms, such as, for example solutions, liquid sprays, lotions, and the like. Additionally, transdermal pharmaceutical compositions include semi-solid dosage forms, such as, for example emulsions, creams, gels, pastes, ointments, and the like. Transdermal pharmaceutical compositions will deliver testosterone and C-SERM through the skin and directly into the patient's bloodstream, thereby providing high bioavailability of testosterone and C-SERM. The dosage regimen of the transdermal pharmaceutical compositions can be easily tailored for individual patients according to the baseline blood levels of testosterone and estradiol.