2-methoxy-3-phenyl-oxirane | 21087-52-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methoxy-3-phenyl-oxirane
• 英文别名: 2-Methoxy-3-phenyl-oxiran；2-Methoxy-3-phenyloxirane
• CAS: 21087-52-5
• 化学式: C₉H₁₀O₂
• 分子量: 150.177
• InChiKey: VGTFUNHNCVWJLL-UHFFFAOYSA-N

物化性质

• 沸点：
  65-67 °C(Press: 1 Torr)
• 密度：
  1.081 g/cm3(Temp: 19 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  21.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methoxy-3-phenyl-oxirane 在 盐酸 、 丙酮 作用下， 生成 2-羟基-2-苯乙醛
  参考文献：
  名称：

  Kirrmann et al., Bulletin de la Societe Chimique de France, 1958, p. 1469,1474

  摘要：

  DOI：
• 作为产物：
  描述：

  Β-苯乙烯甲醚 在 异丁醛 作用下， 以 乙腈 为溶剂， 35.0 ℃ 、101.33 kPa 条件下， 反应 8.0h， 生成 2-methoxy-3-phenyl-oxirane
  参考文献：
  名称：

  Cobalt(II) Schiff base complex on multi-wall carbon nanotubes (MWNTs) by covalently grafted method: Synthesis, characterization and liquid phase epoxidation of cyclohexene by air

  摘要：

  Cobalt [(OH)(2)-salophen] (N,N'-bis(4-hydroxysalicylidene)phenylene-1,2-diamine) complex was covalently grafted on the chemical modification of multi-wall carbon nanotubes (MWNTs); [Co((OH)(2)-salophen)]@MWNTs]. The as-products were characterized by spectroscopy (FT-IR, Raman, and UV-Vis), TGA, and TEM. The cobalt(II) Schiff-base complex covalently anchored on modified MWNTs was characterized by different techniques. The catalytic activity of the novel nanotubes based materials was tested in the epoxidation of cyclohexene in the iso-butyraldehyde/air system using acetonitrile as solvent and very high conversion was obtained. The experimental results indicated very good catalytic activity and selectivity in the epoxidation of cyclohexene. Repeated runs of the catalysts were carried out three times and the results indicated that the catalyst was stable for the epoxidation of cyclohexene. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.03.056

文献信息

• Prodrug and protected forms of 5-hydroxymethylfurfuranal (5-HMF) and its derivatives
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：US10875834B2

  公开（公告）日：2020-12-29

  Prodrugs and derivatives of 5-hydoxymethyl-2-furfural (5-HMF) with protected or modified aldehyde and/or alcohol moieties are provided. The prodrugs or derivatives exhibit increased bioavailability, e.g. due to having extended half-lives in circulation. The drugs are therefore administered i) at lower doses and/or ii) less frequently than 5-HMF, while still maintaining the beneficial therapeutic effects of 5-HMF.

  5-hydoxymethyl-2-furfural (5-HMF) 的原药和衍生物具有受保护或修饰的醛和/或醇分子。这些原药或衍生物具有更高的生物利用度，例如由于其在血液循环中的半衰期更长。因此，与 5-HMF 相比，这些药物 i) 给药剂量更低和/或 ii) 给药次数更少，同时仍能保持 5-HMF 的有益治疗效果。
• Ricci, Alfredo; Fiorenza, Mariella; Degl Innocenti, Alessandro, Angewandte Chemie, 1985, vol. 97, # 12, p. 1068 - 1069
  作者：Ricci, Alfredo、Fiorenza, Mariella、Degl Innocenti, Alessandro、Seconi, Giancarlo、Dembech, Pasquale、et al.

  DOI：——

  日期：——
• RICCI, A.;FIORENZA, M.;DEGLINNOCENTI, A.;SECONI, G.;DEMBECH, P.;WITZGALL,+, ANGEW. CHEM., 1985, 97, N 12, 1068-1069
  作者：RICCI, A.、FIORENZA, M.、DEGLINNOCENTI, A.、SECONI, G.、DEMBECH, P.、WITZGALL,+

  DOI：——

  日期：——
• PRODRUG AND PROTECTED FORMS OF 5-HYDROXYMETHYLFURFURANAL (5-HMF) AND ITS DERIVATIVES
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：US20190256483A1

  公开（公告）日：2019-08-22

  Prodrugs and derivatives of 5-hydoxymethyl-2-furfural (5-HMF) with protected or modified aldehyde and/or alcohol moieties are provided. The prodrugs or derivatives exhibit increased bioavailability, e.g. due to having extended half-lives in circulation. The drugs are therefore administered i) at lower doses and/or ii) less frequently than 5-HMF, while still maintaining the beneficial therapeutic effects of 5-HMF.
• Cobalt(II) Schiff base complex on multi-wall carbon nanotubes (MWNTs) by covalently grafted method: Synthesis, characterization and liquid phase epoxidation of cyclohexene by air
  作者：Masoud Salavati-Niasari、Elahe Esmaeili、Hamideh Seyghalkar、Mehdi Bazarganipour

  DOI：10.1016/j.ica.2011.03.056

  日期：2011.9

  Cobalt [(OH)(2)-salophen] (N,N'-bis(4-hydroxysalicylidene)phenylene-1,2-diamine) complex was covalently grafted on the chemical modification of multi-wall carbon nanotubes (MWNTs); [Co((OH)(2)-salophen)]@MWNTs]. The as-products were characterized by spectroscopy (FT-IR, Raman, and UV-Vis), TGA, and TEM. The cobalt(II) Schiff-base complex covalently anchored on modified MWNTs was characterized by different techniques. The catalytic activity of the novel nanotubes based materials was tested in the epoxidation of cyclohexene in the iso-butyraldehyde/air system using acetonitrile as solvent and very high conversion was obtained. The experimental results indicated very good catalytic activity and selectivity in the epoxidation of cyclohexene. Repeated runs of the catalysts were carried out three times and the results indicated that the catalyst was stable for the epoxidation of cyclohexene. (C) 2011 Elsevier B.V. All rights reserved.