D-(+)-2-hydroxyglutaric acid sodium salt

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: D-(+)-2-hydroxyglutaric acid sodium salt
• 英文别名: (R)-2-hydroxypentanedioic acid, disodium salt；D-α-hydroxyglutaric acid disodium salt；(D)-2-hydroxyglutaric acid disodium salt；D-2HG sodium salt；(R)-2-hydroxy-glutaric acid ; disodium-salt；(R)-2-Hydroxy-glutarsaeure; Dinatrium-Salz；sodium;(2R)-2-hydroxypentanedioate
• 化学式: C₅H₆O₅*2Na
• 分子量: 192.079
• InChiKey: TZUOJYBASJTDDR-AENDTGMFSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -6.37
• 重原子数：
  11.0
• 可旋转键数：
  4.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  100.49
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  D-(+)-2-hydroxyglutaric acid sodium salt 在 4-二甲氨基吡啶 、 silver nitrate 作用下， 以 二氯甲烷 为溶剂， 反应 51.0h， 生成 (R)-2-(2,6-Dinitro-benzoyloxy)-pentanedioic acid dimethyl ester
  参考文献：
  名称：

  Battersby, Alan R.; Cardwell, Kevin S.; Leeper, Finian J., Journal of the Chemical Society. Perkin transactions I, 1986, p. 1565 - 1580

  摘要：

  DOI：

文献信息

• Derivatization of the tricarboxylic acid intermediates with O-benzylhydroxylamine for liquid chromatography–tandem mass spectrometry detection
  作者：Bo Tan、Zhaohai Lu、Sucai Dong、Genshi Zhao、Ming-Shang Kuo

  DOI：10.1016/j.ab.2014.07.027

  日期：2014.11

  The tricarboxylic acid (TCA) cycle is an interface among glycolysis, lipid metabolism, and amino acid metabolism. Increasing interest in cancer metabolism has created a demand for rapid and sensitive methods for quantifying the TCA cycle intermediates and related organic acids. We have developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantify the TCA cycle intermediates in a 96-well format after O-benzylhydroxylamine (O-BHA) derivatization under aqueous conditions. This method was validated for quantitation of all common TCA cycle intermediates with good sensitivity, including alpha-ketoglutarate, malate, fumarate, succinate, 2-hydroxyglutarate, citrate, oxaloacetate, pyruvate, isocitrate, and lactate using a 8-min run time in cancer cells and tissues. The method was used to detect and quantify changes in metabolite levels in cancer cells and tumor tissues treated with a pharmacological inhibitor of nicotinamide phosphoribosyl transferase (NAMPT). This method is rapid, sensitive, and reproducible, and it can be used to assess metabolic changes in cancer cells and tumor samples. (c) 2014 Elsevier Inc. All rights reserved.
• Battersby, Alan R.; Cardwell, Kevin S.; Leeper, Finian J., Journal of the Chemical Society. Perkin transactions I, 1986, p. 1565 - 1580
  作者：Battersby, Alan R.、Cardwell, Kevin S.、Leeper, Finian J.

  DOI：——

  日期：——