(Z)-N'-benzylidene-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carbohydrazide | 1181990-99-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 三唑核糖核苷和核糖核苷酸
• 英文名称: (Z)-N'-benzylidene-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carbohydrazide
• 英文别名: N-[(Z)-benzylideneamino]-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
• CAS: 1181990-99-7
• 化学式: C₁₅H₁₇N₅O₅
• 分子量: 347.33
• InChiKey: RPOBGYZEAAIQIG-GTMFSQISSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  142
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  苯甲醛 、 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carbohydrazide 以 乙醇 、 溶剂黄146 为溶剂， 反应 0.5h， 以79.8%的产率得到(Z)-N'-benzylidene-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carbohydrazide
  参考文献：
  名称：

  Synthesis of novel ribavirin hydrazone derivatives and anti-proliferative activity against A549 lung cancer cells

  摘要：

  A series of novel ribavirin hydrazone derivatives were synthesized by the reaction of ribavirin hydrazone with benzaldehyde or acetophenone derivatives. The structures of the compounds were determined by IR, H-1 NMR, and HRESIMS. Preliminary biological evaluation showed that one compound (7h) inhibits the growth of A549 cells at 20 mu M. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2009.05.017

文献信息

• Synthesis of novel ribavirin hydrazone derivatives and anti-proliferative activity against A549 lung cancer cells
  作者：Wei-Yong Liu、Hai-Ying Li、Bao-Xiang Zhao、Dong-Soo Shin、Song Lian、Jun-Ying Miao

  DOI：10.1016/j.carres.2009.05.017

  日期：2009.7

  A series of novel ribavirin hydrazone derivatives were synthesized by the reaction of ribavirin hydrazone with benzaldehyde or acetophenone derivatives. The structures of the compounds were determined by IR, H-1 NMR, and HRESIMS. Preliminary biological evaluation showed that one compound (7h) inhibits the growth of A549 cells at 20 mu M. (C) 2009 Elsevier Ltd. All rights reserved.