Isopropyl-methyl-phenethyl-amine | 70160-93-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Isopropyl-methyl-phenethyl-amine
• 英文别名: N-methyl-N-(2-phenylethyl)propan-2-amine
• CAS: 70160-93-9
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: HJLQPXCLODDOHV-UHFFFAOYSA-N

物化性质

• 沸点：
  241.5±19.0 °C(Predicted)
• 密度：
  0.904±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Benzyl-isopropyl-methyl-trimethylsilanylmethyl-ammonium; iodide 在 cesium fluoride 作用下， 以 六甲基磷酰三胺 为溶剂， 反应 27.0h， 生成 Methyl-isopropyl-<2-methyl-benzyl>-amin 、 Isopropyl-methyl-phenethyl-amine
  参考文献：
  名称：

  Ylide rearrangement of benzyltrialkylammonium salts: the improved Sommelet-Hauser rearrangement

  摘要：

  DOI：

  10.1021/jo00236a041

文献信息

• [EN] NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS<br/>[FR] COMPOSÉS DE NICOTINAMIDE UTILES EN TANT QUE MODULATEURS DE KINASES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2010144647A1

  公开（公告）日：2010-12-16

  Disclosed are nicotinamide compounds of Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. Also disclosed are methods of using such compounds in the treatment of at least one Btk associated condition, such as, for example, inflammatory disease, and pharmaceutical compositions comprising such compounds.

  公开了Formula (I)的烟酰胺化合物，或其立体异构体或药用盐。还公开了使用这些化合物治疗至少一种Btk相关疾病的方法，例如炎症性疾病，并包括这些化合物的药物组合物。
• Cannabinoid receptor modulators
  申请人：Chackalamannil Samuel

  公开号：US20070197628A1

  公开（公告）日：2007-08-23

  A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, is useful in treating diseases, disorders, or conditions such as obesity, metabolic disorders, addiction, diseases of the central nervous system, cardiovascular disorders, respiratory disorders, and gastrointestinal disorders.

  具有通式（I）的一种化合物：或其药用盐、溶剂合物或酯，可用于治疗肥胖、代谢紊乱、成瘾、中枢神经系统疾病、心血管疾病、呼吸系统疾病和消化系统疾病等疾病、紊乱或症状。
• Application of Grignard reagents to the synthesis of tertiary methylamines via resin-bound oxyiminium ions
  作者：Paul Blaney、Ronald Grigg、Zoran Rankovic、Matthew Thoroughgood

  DOI：10.1016/s0040-4039(00)01104-7

  日期：2000.8

  The solid-phase synthesis of tertiary methylamines via the nucleophilic displacement of benzotriazole Mannich adducts with Grignard reagents using a hydroxylamine linker is described. The chemistry is exemplified by the synthesis of the MAO inhibitor α-methylpargyline. Also described is the synthesis of the analgesic Tramadol by an alternative one-pot solid-phase Mannich reaction.

  描述了使用羟胺接头通过格氏试剂通过苯并三唑曼尼希加合物的亲核取代而固相合成叔甲基胺。该化学反应以MAO抑制剂α-甲基pargyline的合成为例。还描述了通过另一种单锅固相曼尼希反应合成止痛曲马多的方法。
• PHENYLPYRAZOLE DERIVATIVES AS POTENT ROCK1 AND ROCK2 INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：US20140243338A1

  公开（公告）日：2014-08-28

  The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

  本发明提供了式(I)的化合物：或其立体异构体、互变异构体或药学上可接受的盐，其中所有变量如本文所定义。这些化合物是选择性ROCK抑制剂。本发明还涉及包含这些化合物的药物组合物以及使用这些药物组合物治疗心血管、平滑肌、肿瘤学、神经病理学、自身免疫、纤维化和/或炎症性疾病的方法。
• Novel gamma secretase inhibitors
  申请人：Schering-Plough Corporation

  公开号：US20040171614A1

  公开（公告）日：2004-09-02

  This invention discloses novel gamma secretase inhibitors of the formula: 1 wherein: R 1 is a substituted aryl or substituted heteroaryl group; R 2 is an R 1 group, alkyl, —XC(O)Y, alkylene-XC(O)Y, cycloalkylene-X-C(O)—Y, —CH—X—C(O)—NR 3 —Y or —CH—X—C(O)—Y, wherein X and Y are as defined herein; each R 3 and each R 3A are independently H, or alkyl; R 11 is aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. Also disclosed is a method of treating Alzheimer's Disease using one or more compounds of the invention.

  这项发明揭示了一种新颖的伽玛分泌酶抑制剂，其化学式为：其中：R1为取代芳基或取代杂芳基；R2为R1基团、烷基、—XC(O)Y、烷基烯-XC(O)Y、环烷基烯-X-C(O)—Y、—CH—X—C(O)—NR3—Y或—CH—X—C(O)—Y，其中X和Y如本文中所定义；每个R3和每个R3A独立地为H或烷基；R11为芳基、杂芳基、烷基、环烷基、芳基烷基、芳基环烷基、杂芳基烷基、杂芳基环烷基、芳基杂环烷基或烷氧基烷基。还公开了使用该发明的一个或多个化合物治疗阿尔茨海默病的方法。