Methyl-isopropyl-<2-methyl-benzyl>-amin | 70160-72-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl-isopropyl-<2-methyl-benzyl>-amin
• 英文别名: N-methyl-N-[(2-methylphenyl)methyl]propan-2-amine
• CAS: 70160-72-4
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: UNYDFXGYSNCYEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Benzyl-isopropyl-methyl-trimethylsilanylmethyl-ammonium; iodide 在 cesium fluoride 作用下， 以 六甲基磷酰三胺 为溶剂， 反应 27.0h， 生成 Methyl-isopropyl-<2-methyl-benzyl>-amin 、 Isopropyl-methyl-phenethyl-amine
  参考文献：
  名称：

  Ylide rearrangement of benzyltrialkylammonium salts: the improved Sommelet-Hauser rearrangement

  摘要：

  DOI：

  10.1021/jo00236a041

文献信息

• [EN] DPP-IV INHIBITORS<br/>[FR] INHIBITEURS DE LA DPP-IV
  申请人：GRAFFINITY PHARMACEUTICALS AG

  公开号：WO2005095343A1

  公开（公告）日：2005-10-13

  The invention relates to compounds of formula (I), Z-C(R<1>R<2>)-C(R<3>NH2)-C(R<4>R<5>)-X-N(R<6>R<7>), wherein Z, R<1-7> and X have the meaning as cited in the description and the claims. Said compounds are useful as DPP-lV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament.

  该发明涉及式(I)的化合物，其中Z-C(R1R2)-C(R3NH2)-C(R4R5)-X-N(R6R7)，其中Z，R1-7和X的含义如描述和权利要求中所述。所述化合物可用作DPP-IV抑制剂。该发明还涉及制备此类化合物以及其作为药物的生产和使用。
• SHIRAI, NAOHIRO;SATO, YOSHIRO, J. ORG. CHEM., 53,(1988) N 1, 194-196
  作者：SHIRAI, NAOHIRO、SATO, YOSHIRO

  DOI：——

  日期：——
• Inhibitors of post-proline cleaving proteases
  申请人：Evans David M.

  公开号：US20080255126A1

  公开（公告）日：2008-10-16

  Novel compounds that are inhibitors of one or most post-proline cleaving proteases, e.g. dipeptidyl peptidase IV, according to general formula (1). R 1 is H or CN, X 1 is O, S, CH 2 , CHF, CF 2 , CH(CH 3 ), C(CH 3 ) 2 or CH(CN), and b is 1 or 2. G 1 is H or a group according to the formula —CH 2 —X 2 —(CH 2 ) a -G 3 and G 2 is H or a group according to the formula —CH 2 —(CH 2 9 a -G 3 , provided that one of G 1 and G 2 is H and the other is not H. X 2 is O, S, or CH 2 , and a is 0, 1 or 2, provided that when a is 1 then X 2 is CH 2 . G 3 is a group according to one of general formulae 2-4, where the variables have meaning given in the description. The compounds are useful in the treatment of i.a. type 2 diabetes and impaired glucose tolerance.
• US7335677B2
  申请人：——

  公开号：US7335677B2

  公开（公告）日：2008-02-26
• Ylide rearrangement of benzyltrialkylammonium salts: the improved Sommelet-Hauser rearrangement
  作者：Naohiro Shirai、Yoshiro Sato

  DOI：10.1021/jo00236a041

  日期：1988.1