dl-1,6-diphenyl-1,6-hexanediol | 39997-17-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: dl-1,6-diphenyl-1,6-hexanediol
• 英文别名: racem.-1,6-diphenyl-hexane-1,6-diol；racem.-1,6-Diphenyl-hexan-1,6-diol；racem.-1,6-Diphenyl-hexandiol-(1,6)；(1R,6R)-1,6-diphenylhexane-1,6-diol
• CAS: 39997-17-6
• 化学式: C₁₈H₂₂O₂
• 分子量: 270.371
• InChiKey: SXMWTOPZFVZWKJ-QZTJIDSGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dl-1,6-diphenyl-1,6-hexanediol 在 甲基磺酰氯 作用下， 以 吡啶 为溶剂， 反应 24.0h， 以25%的产率得到1,6-dichloro-1,6-diphenylhexane
  参考文献：
  名称：

  Studies toward cyclic trisulfides. Trisulfide polymers and sulfur extrusion

  摘要：

  DOI：

  10.1021/jo00323a019
• 作为产物：
  描述：

  1,6-Diphenyl-2,4-hexadiin-1,6-diol 在 platinum on activated charcoal 氢气 作用下， 生成 dl-1,6-diphenyl-1,6-hexanediol
  参考文献：
  名称：

  Stereochemistry of ?,?-diphenylalkane-?,?-diols; Cyclization and determination of the diastereomeric ratio of the diols formed upon reduction of ?,?-diphenylalkane-?,?-diones

  摘要：

  DOI：

  10.1007/bf00914517

文献信息

• The Prevention of Depressive Symptoms in Children: The Immediate and Long-term Outcomes of a School-based Program
  作者：Clare Pattison、Robert M. Lynd-Stevenson

  DOI：10.1375/bech.18.2.92

  日期：2001.6.1

  The ability of a school-based program with training in both cognitive and social skills to prevent depressive symptoms in children (the Penn Prevention Program) was evaluated. Research conducted in Australia has failed to replicate the success of the program in the United States. Also evaluated was the ability of the program to reduce the symptoms of anxiety, the assumption that changes in social skills and cognitive style would be associated with changes in symptoms of depression and anxiety, and the relative merits of the cognitive and social components of the program. Sixty-three children in fifth and sixth grades were randomly allocated to intervention and control groups. There was no evidence that the Penn Prevention Program had any impact on the variables measured at the end of the program or at the 8-month follow-up assessment. Limitations and implications of the present findings are discussed.

  本研究评估了一个基于学校的项目（宾夕法尼亚预防计划）对儿童抑郁症状的预防效果，该项目对认知和社交技能进行培训。在澳大利亚进行的研究未能复制该项目在美国的成功。同时，还评估了该项目减少焦虑症状的能力，以及社交技能和认知风格的变化是否与抑郁和焦虑症状的变化相关，以及该项目认知和社交组成部分的相对优点。五年级和六年级的63名儿童被随机分配到干预组和对照组。没有证据表明宾夕法尼亚预防计划对项目结束时或8个月随访评估中测量的变量有任何影响。本文讨论了当前发现的局限性和启示。

• Design, synthesis and structure of new chiral squaric acid monoaminoalcohols and diaminoalcohols and their use as catalysts in asymmetric reduction of ketones and diketones
  作者：Hai-Bing Zhou、Ji Zhang、Shou-Mao Lü、Ru-Gang Xie、Zhong-Yuan Zhou、Michael C.K Choi、Albert S.C Chan、Teng-Kuei Yang

  DOI：10.1016/s0040-4020(01)00936-x

  日期：2001.11

  Many chiral squaric acid aminoalcohols and C2-symmetric diaminoalcohols have been synthesized and their in situ formed chiral boron heterocycles have been used as catalysts for the enantioselective reduction of prochiral ketones and diketones by borane to give alcohols with up to 99% enantiomeric excess and 99% yield. The effects of solvent, catalyst–substrate ratio and temperature were also investigated

  已经合成了许多手性方酸氨基醇和C 2对称的二氨基醇，它们的原位形成的手性硼杂环已被用作催化剂，通过硼烷对手性酮和二酮进行对映选择性还原，制得对映体过量高达99％的醇和99 ％ 屈服。还研究了溶剂，催化剂-底物比例和温度的影响。
• Chiral monoaminoalcohols and diaminoalcohols of squaric acid: new catalysts for the asymmetric reduction of ketones by borane
  作者：Haibing Zhou、Shoumao Lü、Rugang Xie、Albert S.C Chan、Teng-Kuei Yang

  DOI：10.1016/s0040-4039(00)02162-6

  日期：2001.2

  Two series of new chiral ligands, squaric acid aminoalcohols and C2-symmetric squaric acid diaminoalcohols have been synthesized. The chiral oxazaborolidines formed in situ from these ligands have been used in the enantioselective borane reduction of prochiral ketones and diketones to afford alcohol products with up to 99% enantiomeric excesses. The structures of the ligands have an obvious effect

  合成了两个系列的新手性配体，方酸氨基醇和C 2对称的方酸二氨基醇。由这些配体原位形成的手性恶唑硼烷已用于手性酮和二酮的对映选择性硼烷还原，以提供对映体过量高达99％的醇产物。配体的结构对所得醇的ee有明显影响。
• Multiple Dendritic Catalysts for Asymmetric Transfer Hydrogenation
  作者：Ying-Chun Chen、Tong-Fei Wu、Jin-Gen Deng、Hui Liu、Xin Cui、Jin Zhu、Yao-Zhong Jiang、Michael C. K. Choi、Albert S. C. Chan

  DOI：10.1021/jo0257795

  日期：2002.7.1

  and were well-characterized by NMR and MS techniques. Their ruthenium complexes prepared in situ had good solubility in the reaction medium (azeotrope of formic acid and triethylamine) and demonstrated high catalytic activity and enantioselectivity comparable to monomeric catalysts in the asymmetric transfer hydrogenation of ketones and imines. Quantitative yields and for some cases a slightly higher

  基于手性二胺的第一代和第二代多个树枝状配体以收敛的方式合成，并通过NMR和MS技术得到了很好的表征。原位制备的钌配合物在反应介质（甲酸和三乙胺的共沸物）中具有良好的溶解性，在酮和亚胺的不对称转移加氢反应中，与单体催化剂相比具有较高的催化活性和对映选择性。在树突状催化中获得定量产率，并且在某些情况下获得更高的对映选择性（高达98.7％ee）。考虑到外围的高局部催化剂浓度，测试了二酮在表面催化单元之间可能的协同反应性，但未发现明显差异。
• Iwai et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1960, vol. 80, p. 156
  作者：Iwai et al.

  DOI：——

  日期：——