nucleophilic attack in biological milieu, which affords them pluripotent signaling capabilities. We report synthetic methods to obtain useful quantities of three main biological nitrated fatty acids (9- and 12-nitro-conjugated linoleic acids and 9-nitro-conjugated linolenic acid) in six or seven steps from commercially available starting materials, for biological evaluation of these naturally occurring
含共轭二烯的
脂肪酸(瘤胃酸和瘤胃酸)是生理条件下硝化的主要底物。它们的硝化产物存在于人类尿液中。这些含硝基二烯的脂质亲电子试剂含有一对强吸电子共轭双键,易于在
生物环境中遭受亲核攻击,这赋予它们多能信号传导能力。我们报道了从市售起始材料中通过六到七个步骤获得有用量的三种主要
生物硝化
脂肪酸(9-和12-硝基
共轭亚油酸和9-硝基共轭
亚麻酸)的合成方法,用于
生物评价这些天然存在的
生物分子。