2-(5-hydroxy-1-pentynyl)-1-iodobenzene | 150723-26-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(5-hydroxy-1-pentynyl)-1-iodobenzene
• 英文别名: 5-(2-iodophenyl)-4-pentyn-1-ol；5-(2-iodophenyl)pent-4-yn-1-ol；5-(2-iodophenyl)-4-pentynol
• CAS: 150723-26-5
• 化学式: C₁₁H₁₁IO
• 分子量: 286.112
• InChiKey: VGKWEQKGLSBJAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(5-hydroxy-1-pentynyl)-1-iodobenzene 在 四(三苯基膦)钯 4-甲基苯磺酸吡啶 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 10.0h， 生成 2-(5-tetrahydropyranyloxy-1-pentynyl)benzonitrile
  参考文献：
  名称：

  通过添加甲醇盐引发的2-炔基苄腈直接阴离子环化为3-取代的-1（2 H）-异喹诺酮和3-亚苄基异吲哚-2-酮

  摘要：

  在回流的甲醇中用甲醇钠处理2-（2-烷基乙炔基）苄腈12小时，得到3-烷基-1（2H）-异喹诺酮，收率适中。在相同的反应条件下，2-（2-芳基乙炔基）苄腈的甲醇分解导致3-亚烷基异吲哚-1-酮的形成。2-（1-己炔基）苄腈部分水解成相应的苯甲酰胺，然后在回流的甲醇中用甲醇钠处理苯甲酰胺，以49％的收率得到3-亚戊叉基异吲哚-1-酮。这表明苯甲酰胺不参与该环化反应。

  DOI：

  10.1016/s0040-4020(99)00812-1
• 作为产物：
  描述：

  4-戊炔-1-醇 、 1,2-二碘苯 在 copper(l) iodide 、 四(三苯基膦)钯 、 正丁胺 作用下， 以 乙醚 为溶剂， 反应 12.0h， 以53%的产率得到2-(5-hydroxy-1-pentynyl)-1-iodobenzene
  参考文献：
  名称：

  Synthesis and aromatisation of cyclic enediyne-containing amino acids

  摘要：

  我们以丙炔甘氨酸和均丙炔甘氨酸为起点，制备了一系列环大小从 10 个原子到 12 个原子不等的含烯二炔的环状氨基酸。研究人员探讨了它们在高温下与伯格曼环化反应的活性。根据烯烃取代基和环的大小，这些烯炔类化合物的环化半衰期存在明显差异。已确定了一种可用于肽的潜在候选化合物。

  DOI：

  10.1039/b815176h

文献信息

• Tandem Enyne Allene−Radical Cyclization:  Low-Temperature Approaches to Benz[<i>e</i>]indene and Indene Compounds
  作者：Janet Wisniewski Grissom、Detlef Klingberg、Dahai Huang、Brian J. Slattery

  DOI：10.1021/jo961049j

  日期：1997.2.1

  multicyclic compounds using the tandem enediyne-radical cyclization, we have developed the tandem enyne allene-radical cyclization which proceeds at temperatures as low as 37 degrees C. The reactions were carried out using three different methods for the preparation of the enyne allenes. The first method involved the [3,3] sigmatropic rearrangement of an enediyne followed by a tandem enyne allene-radical

  为了降低使用串联烯二炔自由基环化制备多环化合物所需的温度，我们开发了串联烯炔丙二烯自由基环化反应，该反应在低至37摄氏度的温度下进行。反应使用三种不同的方法进行用于制备烯炔异戊烯。第一种方法涉及烯二炔的[3,3]σ重排，然后是串联烯炔-异戊二烯-自由基环化。此反应可以通过热解（150摄氏度）或通过AgBF（4）重排，然后在75摄氏度加热来实现。第二种技术是在-78摄氏度下利用烯键的[2,3]σ位移，然后在37或75摄氏度下进行串联环化反应，具体取决于底物。
• High temperature radical cyclization anomalies in the tandem enediyne-bis-radical cyclization
  作者：Janet Wisniewski Grissom、Trevor L. Calkins、Dahai Huang、Heidi McMillen

  DOI：10.1016/s0040-4020(01)85004-3

  日期：1994.4

  shown that the thermolysis of aromatic enediynes containing radical accepting tethers will undergo tandem enediyne-radical cyclizations. Herein will be reported several examples of the tandem enediyne-bis-radical cyclization where non-radical accepting tethers will undergo cyclizations to aromatic rings to result in cyclization products. Most of the unusual products result from 1,5-hydrogen abstraction

  先前的报道表明，含有自由基接受的系链的芳族烯二炔的热分解将经历串联的烯二炔-自由基环化。本文将报道双烯二炔双自由基环化的几个例子，其中非自由基接受的束缚剂将环化成芳环以产生环化产物。大多数不寻常的产物是由1，5-氢的提取，然后是β消除或自由基加成到芳环上。描述了芳族烯二炔的合成，机理以及热解产物。
• Enediyne- and Tributyltin Hydride-Mediated Aryl Radical Additions onto Various Radical Acceptors
  作者：Janet Wisniewski Grissom、Detlef Klingberg、Sabine Meyenburg、Brenda L. Stallman

  DOI：10.1021/jo00104a053

  日期：1994.12

  Tandem enediyne-radical cyclizations were carried out on substrates that contain nitrile and ketone radical accepters. The products of these cyclizations and the previously reported tandem enediyne-radical cyclizations containing aldehyde and oxime ether radical accepters were compared with tributyltin hydride-mediated aryl radical addition reactions with 1-bromonaphthalene derivatives containing aldehyde, oxime ether, nitrile, and ketone radical accepters, since these substrates go through similar initial radical intermediates. Although many of the same products were observed using either method of aryl radical generation, there were distinct differences in the product composition and identity depending on which method was used. These differences can probably be primarily attributed to the temperature difference of the two modes of radical generation.
• Kinetic and mechanistic studies of the tandem enediyne-radical cyclization
  作者：Janet Wisniewski Grissom、Trevor L. Calkins

  DOI：10.1021/jo00072a026

  日期：1993.9

  Enediynes 11 possessing a tethered olefin radical acceptor can participate in a tandem enediyne-radical cyclization to yield dihydrobenzindene derivatives 16. In the present study, the mechanism of this reaction was investigated utilizing kinetic studies to determine whether the mechanism was a radical chain, stepwise, or concerted process. Substrate concentration, 1,4-cyclohexadiene concentration, olefin geometry, and olefin electronics were varied. These experiments demonstrate that the reaction occurs under first-order kinetics over a wide variation in either substrate or 1,4-CHD concentration. The reaction rate is also independent of olefin geometry and olefin electronics. The rate constants for the reactions were similar and ranged from 3.0 X 10(4) s-1 to 6.0 X 10(-4) s-1. The data suggests that the tandem enediyne-radical cyclization proceeds through a distinct 1,4-diyl reactive intermediate such as 5 formed in the rate-determining enediyne cyclization step, followed by a radical cyclization to give 16. The tandem enediyne-radical cyclization mechanism is supported by trapping the intermediate biradical 18 in a tandem enediyne-6-exo-radical cyclization of 17 to give products 19a,b.
• Synthetic studies of the tandem enediyne-mono- and bisradical cyclizations
  作者：Janet Wisniewski Grissom、Trevor L. Calkins、Miles Egan

  DOI：10.1021/ja00078a013

  日期：1993.12

  The readily synthesized enediynes 12a-j possessing a tethered olefin radical acceptor can participate in a tandem enediyne-radical cyclization to yield dibydrobenzindene derivatives 14a-j. In the present study, the scope of this reaction was expanded to include a wide variety of olefin acceptors. Substitution at both ends of olefin leads to the formation of two diastereomers 14b and 14c in a 3.5:1 ratio when R3 is Me and R2 is CO2Me. The structures of the dihydrobenzindene products 14b and 14c were confirmed by generating a radical from 25 by a tributyltin hydride reaction which undergoes radical cyclization; this radical is similar to the enediyne-generated radical, which also cyclizes. It was shown that, in 14i and 14j, a substituent at R1 slowed the reaction but still resulted in a good to excellent yield of product. A tandem enediyne-6-exo-radical cyclization of 16 was also carried out but did not work as well as its 5-exo counterpart 12a. Finally, an enediyne 33 containing two olefinic tethers was cyclized in a process to form tetracycle 34 where three rings were formed in one synthetic operation.