(1-benzenesulfonylpiperidin-4-yl)diphenylmethanol | 950054-08-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1-benzenesulfonylpiperidin-4-yl)diphenylmethanol
• 英文别名: [1-(Benzenesulfonyl)piperidin-4-yl]-diphenylmethanol
• CAS: 950054-08-7
• 化学式: C₂₄H₂₅NO₃S
• 分子量: 407.533
• InChiKey: FWYHKHTUNNWLCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (1-benzenesulfonylpiperidin-4-yl)diphenylmethanol 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 生成 1-(Benzenesulfonyl)-4-(diphenylmethylidene)piperidine
  参考文献：
  名称：

  CAN-mediated rearrangement of 4-benzhydrylidenepiperidines

  摘要：

  Several 1-substituted phenyl-(4-phenylpiperidin-4-yl)methanones are synthesized in modest overall yields starting from the reaction of different 1-substituted 4-benzhydrylidenepiperidines via CAN-mediated rearrangement. This facile strategy was also used to synthesize meperidine analog. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.09.068
• 作为产物：
  描述：

  4-苯甲酰基哌啶盐酸盐 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (1-benzenesulfonylpiperidin-4-yl)diphenylmethanol
  参考文献：
  名称：

  CAN-mediated rearrangement of 4-benzhydrylidenepiperidines

  摘要：

  Several 1-substituted phenyl-(4-phenylpiperidin-4-yl)methanones are synthesized in modest overall yields starting from the reaction of different 1-substituted 4-benzhydrylidenepiperidines via CAN-mediated rearrangement. This facile strategy was also used to synthesize meperidine analog. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.09.068

文献信息

• Synthesis and in vitro antiproliferative activity of diphenyl(sulphonylpiperidin-4-yl)methanol derivatives
  作者：S. B. Benaka Prasad、K. Vinaya、C. S. Ananda Kumar、Sanjay Swarup、K. S. Rangappa

  DOI：10.1007/s00044-009-9186-8

  日期：2010.4

  A series of novel diphenyl(piperidin-4-yl)methanol derivatives 10(a-n) were synthesized and characterized by H-1 NMR, LC/MS, FTIR, and elemental analyses. All the synthesized compounds were evaluated for cell proliferation by MTT assay. The antiproliferative effects of the synthesized compounds were tested against viable human skin fibroblast cell line and carcinoma cell lines, namely HeLa cells, HT-29 cells, MCF-7 cells, and HepG-2 cells in comparing the positive and negative control. Among the synthesized compounds, (10b) and (10g) have been identified as potent antiproliferative agents.