2,3-Dihydro-2-methyl-5-phenyl-1H-2-benzazepine | 21971-47-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 2,3-Dihydro-2-methyl-5-phenyl-1H-2-benzazepine
• 英文别名: 1H-2-Benzazepine, 2,3-dihydro-2-methyl-5-phenyl-；2-methyl-5-phenyl-1,3-dihydro-2-benzazepine
• CAS: 21971-47-1
• 化学式: C₁₇H₁₇N
• 分子量: 235.329
• InChiKey: IKMVVSVCIYTDJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-methyl-N-methylene-3,3-diphenylprop-2-en-1-ide-1-aminium 以 xylene 为溶剂， 生成 2,3-Dihydro-2-methyl-5-phenyl-1H-2-benzazepine
  参考文献：
  名称：

  1,7-Electrocyclisation of non-stabilised azomethine ylides

  摘要：

  Non-stablilised alpha,beta,gamma,delta-unsaturated azomethine ylides 3 were generated by the decarboxylation method from 3,3-diarylpropenals 1 and secondary amino acids 2. 1,7-Electrocyclisation of these azomethine ylides, followed by a 1,5-hydrogen shift, gives 2,3-dihydro-1H-2-benzazepines 4. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00466-3

文献信息

• Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
  申请人：Molino F. Bruce

  公开号：US20070021408A1

  公开（公告）日：2007-01-25

  The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R 1 -R 9 are as defined herein.

  本发明的化合物由以下具有式I(A-E)和式(II)的芳基和杂芳基取代的四氢苯并哌啶和二氢苯并哌啶衍生物表示：其中指定为*的碳原子处于R或S构型，取代基X和R1-R9如本文所定义。
• 1,7-Electrocyclisation of non-stabilised α,β∶γ,δ-unsaturated azomethine ylides
  作者：Andrea Arany、David Bendell、Paul W. Groundwater、Ian Garnett、Miklós Nyerges

  DOI：10.1039/a904571f

  日期：——

  The generation of α,β∶γ,δ-unsaturated azomethine ylides 8 is described, starting from N-substituted α-amino acids 7 and aldehydes 6, 12. These azomethine ylides undergo a 1,7-electrocyclisation, followed by a [1,5]-hydrogen shift, to give the dihydrobenzazepines 10a–f and 13.

  描述了从N-取代的α-氨基酸7和醛6、12出发生成α,β γ,δ-不饱和叠氮甲亚胺叶立德8的过程。这些叠氮甲亚胺叶立德经历1,7-电环化反应，随后发生[1,5]-氢迁移，得到二氢苯并氮杂草10a–f和13。
• ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN
  申请人：MOLINO Bruce F.

  公开号：US20090118260A1

  公开（公告）日：2009-05-07

  The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R 1 -R 9 are as defined herein.

  本发明的化合物由以下具有式I（A-E）和式II的芳基和杂芳基取代的四氢苯并咪唑和二氢苯并咪唑衍生物表示：其中指定*的碳原子处于R或S构型，取代基X和R1-R9如本文所定义。
• ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN
  申请人：Albany Molecular Research, Inc.

  公开号：EP1904069B1

  公开（公告）日：2018-06-13
• US7956050B2
  申请人：——

  公开号：US7956050B2

  公开（公告）日：2011-06-07