1-methyl-4-((1-phenylprop-2-yn-1-yl)oxy)benzene | 121507-51-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-methyl-4-((1-phenylprop-2-yn-1-yl)oxy)benzene
• 英文别名: 1-Methyl-4-(1-phenylprop-2-ynoxy)benzene
• CAS: 121507-51-5
• 化学式: C₁₆H₁₄O
• 分子量: 222.287
• InChiKey: VPXAGLBLSSICOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-methyl-4-((1-phenylprop-2-yn-1-yl)oxy)benzene 以 various solvent(s) 为溶剂， 反应 0.5h， 以95%的产率得到6-methyl-2-phenyl-2H-chromene
  参考文献：
  名称：

  克莱森重排法合成黄酮-3-烯的新方法

  摘要：

  1-芳基丙-2-炔基芳基醚（）在N，N-二乙基苯胺/邻二氯苯中进行容易的Claisen重排，从而以高收率得到黄三烯。

  DOI：

  10.1016/s0040-4039(00)82458-2
• 作为产物：
  描述：

  对甲酚 、 (+/-)-1-苯基-2-丙炔-1-醇 以51%的产率得到1-methyl-4-((1-phenylprop-2-yn-1-yl)oxy)benzene
  参考文献：
  名称：

  克莱森重排法合成黄酮-3-烯的新方法

  摘要：

  1-芳基丙-2-炔基芳基醚（）在N，N-二乙基苯胺/邻二氯苯中进行容易的Claisen重排，从而以高收率得到黄三烯。

  DOI：

  10.1016/s0040-4039(00)82458-2

文献信息

• 알카인을 이용한 아마이드 화합물의 제조방법 및 이를 이용한 펩타이드 제조 방법
  申请人：Seoul National University R&DB Foundation 서울대학교산학협력단(120070509242) Corp. No ▼ 114371-0009224BRN ▼119-82-03684

  公开号：KR20170011773A

  公开（公告）日：2017-02-02

  본 발명은 전이금속촉매의 존재 하에 알카인 및 N-하이드록시 화합물을 유기용매 내에서 교반하여 아마이드 결합을 형성시키는 단계를 포함하는 아마이드 화합물의 제조방법 및 이를 이용한 펩타이드 제조방법에 관한 것으로, 본 발명에 의한 아마이드화 반응은 기존의 단순한 친핵성 및 친전자성과 같은 극성 반응성에 의존하지 않고 알카인과 전이금속의 배위결합 반응성에서 도출된 반응을 기반으로 하여 탁월한 화학선택성을 나타낸다. 또한, 펩타이드 합성시 소모적인 보호기 부착 및 탈착 반응 단계를 필요로 하지 않고 반응공정이 간단하여 폴리펩타이드 계열의 화합물을 합성하는데 매우 효과적일 뿐 아니라 반응 도중 출발물질이 소실되지 않기 때문에 100%의 원자경제성을 갖는다.

  This invention relates to a method for producing amide compounds, which includes a step of stirring alkaline and N-hydroxy compounds in an organic solvent under the presence of a transition metal catalyst to form amide bonds, and a peptide production method using the same. The amide reaction according to the present invention is based on the reactivity derived from the coordination reaction between alkaline and transition metals, rather than relying on conventional polar reactions such as simple nucleophilic and electrophilic reactions, demonstrating excellent chemical selectivity. Furthermore, the peptide synthesis process does not require consuming protective group attachment and detachment reactions, and the reaction process is simple, making it very effective for synthesizing compounds in the polyamide series, while also maintaining 100% atom efficiency as the starting materials are not lost during the reaction.
• Mercury(II) trifluoroacetate-mediated transformation of 3-bromo-1-phenylprop-2-ynyl aryl ethers; a novel synthesis of flavanones
  作者：R. Sankara Subramanian、K. K. Balasubramanian

  DOI：10.1039/c39900001469

  日期：——

  The synthesis and mercury(II) trifluoroacetate mediated transformation of 3-bromo-1-phenylprop-2-ynyl aryl ethers to flavanones is reported.

  报道了3-溴-1-苯基丙-2-炔基芳基醚的合成和由三氟乙酸汞（II）介导的向黄烷酮的转化。
• SUBRAMANIAN, R. SANKARA;BALASUBRAMANIAN, K. K., SYNTH. COMMUN., 19,(1989) N-8, C. 1255-1259
  作者：SUBRAMANIAN, R. SANKARA、BALASUBRAMANIAN, K. K.

  DOI：——

  日期：——
• SUBRAMANIAN, SANKARA R.;BALASUBRAMANIAN, K. K., J. CHEM. SOC. CHEM. COMMUN.,(1990) N1, C. 1469-1470
  作者：SUBRAMANIAN, SANKARA R.、BALASUBRAMANIAN, K. K.

  DOI：——

  日期：——
• SUBRAMANIAN, RAJARAM SANKARA;BALASUBRAMANIAN, KALPATTU KUPPUSAMY, TETRAHEDRON. LETT., 29,(1988) N 51, C. 6797-6800
  作者：SUBRAMANIAN, RAJARAM SANKARA、BALASUBRAMANIAN, KALPATTU KUPPUSAMY

  DOI：——

  日期：——