(E)-gamma-hydroxy-alpha,beta-unsaturated sulfones have been readily functionalized at alpha-position via protection of hydroxyl group, metalation with n-BuLi and subsequent reaction with electrophiles. The conjugate addition of organolithiums to (E)-gamma-methoxymethoxy-alpha-trimethylsilyl-alpha, beta-unsaturated phenyl sulfones in Et2O is highly syn-stereoselective.
(E)-γ-羟基-α,β-未饱和砜经过羟基的保护后,可以在α位置容易地进行功能化反应。添加三甲基--
硅基α,β-未饱和苯砜的
有机锂试剂在
乙醚中的共轭加成具有高度的合成同素异构选择性。