2-硝基苯基棕榈酸酯 | 104809-26-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 中文名称: 2-硝基苯基棕榈酸酯
• 英文名称: palmitic acid-(2-nitro-phenyl ester)
• 英文别名: Palmitinsaeure-(2-nitro-phenylester)；o-Nitrophenylhexadecanoat；2-Nitrophenyl palmitate；(2-nitrophenyl) hexadecanoate
• CAS: 104809-26-9
• 化学式: C₂₂H₃₅NO₄
• 分子量: 377.524
• InChiKey: GOOWMQLOYNJICV-UHFFFAOYSA-N

物化性质

• 沸点：
  479.7±28.0 °C(Predicted)
• 密度：
  1.020±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  27
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• WGK Germany：
  3
• 海关编码：
  2915709000

SDS

Version 1.0
Regulation (EC) No 1907/2006

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1 - Product and Company Information

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Product Name O-NITROPHENYL PALMITATE

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2 - Hazards Identification

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3 - Composition/Information on Ingredients

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Product Name CAS # EC no Annex I
Index Number
O-NITROPHENYL PALMITATE 104809-26-9 None None
Formula C22H35NO4
Molecular Weight 377,5000 AMU

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4 - First Aid Measures

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5 - Fire Fighting Measures

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6 - Accidental Release Measures

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7 - Handling and Storage

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STORAGE
Store at -20°C

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8 - Exposure Controls / Personal Protection

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9 - Physical and Chemical Properties

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pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
SIGMA www.molbase.com
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A

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10 - Stability and Reactivity

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11 - Toxicological Information

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12 - Ecological Information

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No data available.

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13 - Disposal Considerations

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14 - Transport Information

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RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.

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15 - Regulatory Information

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Caution: Substance not yet fully tested (EU).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
Self-Classification

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16 - Other Information

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WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
SIGMA www.molbase.com
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
SIGMA www.molbase.com

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

棕榈酸2-硝基苯基酯是用于生命科学相关研究的生物化学试剂，可以作为生物材料或有机化合物使用。

反应信息

• 作为反应物：
  描述：

  2-硝基苯基棕榈酸酯 反应 0.08h， 生成 棕榈酸
  参考文献：
  名称：

  Shell-detachable nanoparticles based on a light-responsive amphiphile for enhanced siRNA delivery

  摘要：

  新型光响应纳米粒子基于两亲物，其亲水性头部和疏水性尾部之间具​​有单个光不稳定连接体，被开发用于小干扰 RNA (siRNA) 递送。在紫外线照射下，连接的断裂导致纳米粒子的外壳快速分离，从而促进 siRNA 的释放并提高基因沉默效率。

  DOI：

  10.1039/c3ra44866e
• 作为产物：
  描述：

  硝苯酚 、 棕榈酰氯 生成 2-硝基苯基棕榈酸酯
  参考文献：
  名称：

  Auwers; Bergs; Winternitz, Justus Liebigs Annalen der Chemie, 1904, vol. 332, p. 206

  摘要：

  DOI：

文献信息

• [EN] PHOTOSENSITIVE AMINOACID-MONOMER LINKAGE AND BIOCONJUGATION APPLICATIONS IN LIFE SCIENCES AND BIOTECHNOLOGY<br/>[FR] LIAISON ACIDE AMINÉ/MONOMÈRE PHOTOSENSIBLE ET APPLICATIONS DE BIOCONJUGAISON EN SCIENCES BIOLOGIQUES ET EN BIOTECHNOLOGIE
  申请人：SAY RIDVAN

  公开号：WO2011070402A1

  公开（公告）日：2011-06-16

  This invention is related to preparation of photosensitive ruthenium based aminoacid monomers and oligomers, aminoacid monomer-protein cross- linking using photo sensitat ion and conjugation on micro and nano-structures by ruthenium-chelate based monomers. Its vast range biotechnolgy applications of multifunctional, biocompatible, stabilE and specific micro and nanobio-conjugates, which will stand-alone or simultaneously enable (i) both purification and determination, (ii) both targeting and imaging and theranostics and (iii) catalysis and determination. The construction and method of preparation is applicable to silica materials, superparamagnetic particles, QDs, CNTs, Ag/ Au nanoparticles and Au surfaces and polymeric materials. The photosensitive aminoacid monomer linkers can react via chemically and biocompatible to a lot of different micro and nano-surface and then to the protein when they act as a single-step cross-linking reaction using irradiation. The photosensitive conjugation based on click biochemistry can be carried out at mild conditions, independent of pH and temperature, without affecting conformation and function of protein.

  这项发明涉及制备光敏钌基氨基酸单体和寡聚体，利用光敏化合物进行氨基酸单体-蛋白质交联，并通过基于钌螯合物的单体在微纳结构上进行共轭。其广泛的生物技术应用包括多功能、生物相容性、稳定和特异性的微纳生物共轭物，可单独或同时实现(i)纯化和测定、(ii)靶向和成像、治疗学和(iii)催化和测定。该构造和制备方法适用于硅材料、超顺磁性颗粒、量子点、碳纳米管、Ag/Au纳米颗粒和Au表面以及聚合材料。光敏氨基酸单体连接剂可以通过化学和生物相容性与许多不同的微纳表面反应，然后在它们作为单步交联反应时通过辐射作用于蛋白质。基于点击生物化学的光敏共轭可以在温和条件下进行，不受pH和温度的影响，不会影响蛋白质的构象和功能。
• Anti-fouling Paints and Coatings
  申请人：Reactive Surfaces LTD

  公开号：US20150191607A1

  公开（公告）日：2015-07-09

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peptide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文披露了聚合材料，例如涂层、塑料、层压材料、复合材料、弹性体、粘合剂或密封剂；表面处理，例如纺织品整理或蜡；填充剂，用于这种聚合材料或表面处理，包括酯酶（例如脂肪水解酶、硫酸酯水解酶、有机磷化合物降解酶）的酶，降解细胞壁和/或细胞膜成分的酶（例如溶菌酶、裂解转葡糖苷酶），生物杀菌或生物稳定肽，和/或肽酶。本文还披露了通过将酶并入能够通过脂肪水解酶、水解酶和/或脲酶的活性进行化学交联的材料中，改变材料性能（例如使用寿命、柔韧性或刚度）的方法。
• Lipolytic Enzyme. Uses Thereof In The Food Industry
  申请人：Danisco A/S

  公开号：EP2267107A2

  公开（公告）日：2010-12-29

  The invention also encompases the use of a lipolytic enzyme obtainable from one of the following genera: Streptomyces, Corynebacterium and Thermobifida in various methods and uses, wherein said lipolytic enzyme is capable of hydrolysing a glycolipid or a phospholipid or transferring an acyl group from a glycolipid or phospholipids to a acyl acceptor. Preferably, the lipolytic enzyme for use in these methods and uses comprises an amino acid sequence as shown in any one of SEQ. ID. No.s 4, 5, 7, 8, 12, 14 or 16 or an amino acid sequence having at least 70% identity therewith or comprises a nucleotide sequence shown as SEQ ID No. 3, 6, 9, 13, 15 or 17 or a nulceotide seqeunce which has at least 70% identity therewith. The present invention also relates to a lipolytic enzyme capable of hydrolysing at least a galactolipid or capable of transferring an acyl group from a galactolipid to one or more acyl acceptor substrates, wherein the enzyme is obtainable from Steptomyces species and includes a lipolytic enzyme comprising an amino acid sequence as shown in SEQ ID No. 4 or an amino acid sequence which has at least 60% identity thereto. The enzyme may be encoded by a nucleic acid selected from the group consisting of: a nucleic acid comprising a nucleotide sequence shown in SEQ ID No. 3; a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3 by the degeneration of the genetic code; and a nucleic acid comprising a nucleotide sequence which has at least 70% identity with the nucleotide sequence shown in SEQ ID No. 3.

  本发明还包括在各种方法和用途中使用可从以下属种之一获得的脂肪分解酶：其中所述脂肪分解酶能够水解糖脂或磷脂或将酰基从糖脂或磷脂转移到酰基受体。优选地，用于这些方法和用途的脂肪分解酶包括 SEQ.ID.4、5、7、8、12、14 或 16 中任何一个所示的氨基酸序列，或与之至少有 70% 相同性的氨基酸序列，或包括 SEQ ID No.3、6、9、13、15 或 17 所示的核苷酸序列，或与之至少有 70% 相同性的核苷酸序列。本发明还涉及一种能水解至少一种半乳糖脂或能将酰基从半乳糖脂转移到一种或多种酰基受体底物上的脂肪分解酶，其中该酶可从担子菌中获得，并包括一种脂肪分解酶，其氨基酸序列如SEQ ID No.4所示或与其至少有60%相同性的氨基酸序列。该酶可由选自以下组的核酸编码： 包含 SEQ ID 编号 3 中所示核苷酸序列的核酸； 通过遗传密码的退化与 SEQ ID 3 的核苷酸序列相关的核酸；以及 由核苷酸序列组成的核酸，该核苷酸序列与 SEQ ID No.
• Enzymatic oil-degumming method
  申请人：Danisco A/S

  公开号：EP2275522A2

  公开（公告）日：2011-01-19

  The invention also encompasses the use of a lipolytic enzyme obtainable from one of the following genera: Streptomyces, Corynebacterium and Thermobifida in various methods and uses, wherein said lipolytic enzyme is capable of hydrolysing a glycolipid or a phospholipid or transferring an acyl group from a glycolipid or phospholipids to a acyl acceptor. Preferably, the lipolytic enzyme for use in these methods and uses comprises an amino acid sequence as shown in any one of SEQ. ID. No.s 4, 5, 7, 8, 12, 14 or 16 or an amino acid sequence having at least 70% identity therewith or comprises a nucleotide sequence shown as SEQ ID No. 3, 6, 9, 13, 15 or 17 or a nulceotide seqeunce which has at least 70% identity therewith. The present invention also relates to a lipolytic enzyme capable of hydrolysing at least a galactolipid or capable of transferring an acyl group from a galactolipid to one or more acyl acceptor substrates, wherein the enzyme is obtainable from Steptomyces species and includes a lipolytic enzyme comprising an amino acid sequence as shown in SEQ ID No. 4 or an amino acid sequence which has at least 60% identity thereto. The enzyme may be encoded by a nucleic acid selected from the group consisting of: a nucleic acid comprising a nucleotide sequence shown in SEQ ID No. 3; a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3 by the degeneration of the genetic code; and a nucleic acid comprising a nucleotide sequence which has at least 70% identity with the nucleotide sequence shown in SEQ ID No. 3.

  本发明还包括在各种方法和用途中使用可从以下属种之一获得的脂肪分解酶：其中所述脂肪分解酶能够水解糖脂或磷脂，或将酰基从糖脂或磷脂转移到酰基受体上。优选地，用于这些方法和用途的脂肪分解酶包括 SEQ.ID.4、5、7、8、12、14 或 16 中任何一个所示的氨基酸序列，或与之至少有 70% 相同性的氨基酸序列，或包括 SEQ ID No.3、6、9、13、15 或 17 所示的核苷酸序列，或与之至少有 70% 相同性的核苷酸序列。本发明还涉及一种能水解至少一种半乳糖脂或能将酰基从半乳糖脂转移到一种或多种酰基受体底物上的脂肪分解酶，其中该酶可从担子菌中获得，并包括一种脂肪分解酶，其氨基酸序列如SEQ ID No.4所示或与其至少有60%相同性的氨基酸序列。该酶可由选自以下组的核酸编码： 包含 SEQ ID 编号 3 中所示核苷酸序列的核酸； 通过遗传密码的退化与 SEQ ID 3 的核苷酸序列相关的核酸；以及 由核苷酸序列组成的核酸，该核苷酸序列与 SEQ ID No.
• TRANS-TUMORAL PEPTIDE SPECIFIC TO NEUROPILIN AND FUSION PROTEIN HAVING SAME PEPTIDE FUSED THEREIN
  申请人：Ajou University Industry-Academic Cooperation Foundation

  公开号：EP3000825A1

  公开（公告）日：2016-03-30

  The present invention relates to a tumor tissue-penetrating peptide specifically binding to neuropilin, or a fusion protein, a small molecule drug, a nanoparticle, or a liposome having the peptide fused therein. In addition, the present invention relates to a method for preparing the same and a pharmaceutical composition comprising the same for treating, diagnosing, or preventing cancer or angiogenesis-related diseases. The fusion antibody in which a tumor tissue-penetrating peptide according to the present invention is fused to the C-terminus of an anticancer antibody heavy-chain constant region (Fc) achieves the property of specifically binding to neuropilin, and thereby, specifically accumulates in tumor tissue, widens intercellular gaps between tumor vascular endothelial cells, promotes extravasation, increases infiltration within tumor tissue, and thus, shows a remarkably increased in vivo tumor-suppressing activity. Furthermore, the fusion protein having a tumor tissue-penetrating peptide according to the present invention fused therein inhibits the angiogenic function among the functions of neuropilin coreceptors resulting from targeting of neuropilin, and is therefore expected to have an alleviating effect on angiogenesis-related diseases.

  本发明涉及一种与神经肽特异性结合的肿瘤组织穿透肽，或一种融合蛋白、一种小分子药物、一种纳米颗粒或一种脂质体，其中融合了该肽。此外，本发明还涉及一种制备方法和一种包含该方法的药物组合物，用于治疗、诊断或预防癌症或血管生成相关疾病。本发明中的肿瘤组织穿透肽与抗癌抗体重链恒定区（Fc）的 C 端融合的融合抗体具有与神经肽特异性结合的特性，因此可在肿瘤组织中特异性蓄积，扩大肿瘤血管内皮细胞之间的细胞间隙，促进外渗，增加肿瘤组织内的浸润，从而显著提高体内抑瘤活性。此外，根据本发明，具有肿瘤组织穿透肽的融合蛋白可抑制神经肽核心受体靶向导致的血管生成功能，因此有望对血管生成相关疾病产生缓解作用。