2,6-Dichlorophenyl chloroformate | 374568-08-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-Dichlorophenyl chloroformate
• 英文别名: (2,6-dichlorophenyl) carbonochloridate
• CAS: 374568-08-8
• 化学式: C₇H₃Cl₃O₂
• 分子量: 225.459
• InChiKey: BJGSBVNUAAUCTQ-UHFFFAOYSA-N

物化性质

• 沸点：
  115-120 °C(Press: 16 Torr)
• 密度：
  1.545±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2,3,4-四氢异喹啉-2-胺 、 2,6-Dichlorophenyl chloroformate 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (3,4-Dihydro-1H-isoquinolin-2-yl)-carbamic Acid 2.6-dichloro-phenyl Ester
  参考文献：
  名称：

  Carbazates as potent inhibitors of hormone-sensitive lipase

  摘要：

  The central role of adipose tissue hormone-sensitive lipase in regulating fatty acid metabolism makes it a potential pharmacological target for the prevention of peripheral insulin resistance in obese, prediabetic and diabetic individuals. The synthesis of a new series of carbazates is presented. Modification of the phenolic 4-position in a series of 1,2,3,4-tetrahydroisoquinoline and morpholine derived carbazates, yielded inhibitors of the catalytic activity of this enzyme with nanomolar potency. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.038
• 作为产物：
  描述：

  光气 、 2,6-二氯苯酚 在 N,N-二甲基苯胺 作用下， 以 甲苯 为溶剂， 以93%的产率得到2,6-Dichlorophenyl chloroformate
  参考文献：
  名称：

  Carbamate triserine lactone receptors for anion recognition

  摘要：

  We have taken advantage of the ability of the cyclic triester of L-serine to organize ligand units appended to the three alpha-amine functionalities, as in enterobactin, a siderophore produced by enteric bacteria that binds ferric ion exceptionally well (K-f = 10(49)). As an extension of the preorganization concept, this work describes the preparation and characterization of carbamate triserine lactone receptors 1-6 and their ability to act as molecular receptors for anions. These receptors bind halides (F- >> Cl- > Br- > I-) with binding constants K in the range 21-7350 L mol(-1). (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.08.081

文献信息

• Compounds for treating disorders where a decreased level of plasma FFA is desired
  申请人：——

  公开号：US20020082254A1

  公开（公告）日：2002-06-27

  The present invention relates to novel compounds, compositions containing them, and their use for treating medical disorders where a decreased level of plasma free fatty acids (FFA) is desired.

  这项发明涉及新化合物、含有这些化合物的组合物，以及它们用于治疗需要降低血浆游离脂肪酸（FFA）水平的医学疾病的用途。
• REITER J.; PONGO L.; DVORTSAK P., J. HETEROCYCL. CHEM., 24,(1987) N 1, 127-142
  作者：REITER J.、 PONGO L.、 DVORTSAK P.

  DOI：——

  日期：——
• [EN] COMPOUNDS FOR TREATING DISORDERS WHERE A DECREASED LEVEL OF PLASMA FFA IS DESIRED<br/>[FR] COMPOSES DESTINES AU TRAITEMENT DE TROUBLES DANS LESQUELS UNE DIMINUTION DU NIVEAU D'AGL DU PLASMA EST VOULUE
  申请人：NOVO NORDISK AS

  公开号：WO2001087843A1

  公开（公告）日：2001-11-22

  The present invention relates to novel compounds of general formula (I), wherein A is a nitrogen containing ring systen attached through the nitrogen atom, compositions containing them, and their use for treating medical disorders where a decreased level of plasma free fatty acids (FFA) is desired.
• Carbamate triserine lactone receptors for anion recognition
  作者：Yizhe Wang、Edward Duran、David Nacionales、Amber Valencia、Christopher Wostenberg、Eric R. Marinez

  DOI：10.1016/j.tetlet.2008.08.081

  日期：2008.11

  We have taken advantage of the ability of the cyclic triester of L-serine to organize ligand units appended to the three alpha-amine functionalities, as in enterobactin, a siderophore produced by enteric bacteria that binds ferric ion exceptionally well (K-f = 10(49)). As an extension of the preorganization concept, this work describes the preparation and characterization of carbamate triserine lactone receptors 1-6 and their ability to act as molecular receptors for anions. These receptors bind halides (F- >> Cl- > Br- > I-) with binding constants K in the range 21-7350 L mol(-1). (C) 2008 Elsevier Ltd. All rights reserved.
• Carbazates as potent inhibitors of hormone-sensitive lipase
  作者：Johannes C. de Jong、Lotte G. Sørensen、Hans Tornqvist、Poul Jacobsen

  DOI：10.1016/j.bmcl.2004.01.038

  日期：2004.4

  The central role of adipose tissue hormone-sensitive lipase in regulating fatty acid metabolism makes it a potential pharmacological target for the prevention of peripheral insulin resistance in obese, prediabetic and diabetic individuals. The synthesis of a new series of carbazates is presented. Modification of the phenolic 4-position in a series of 1,2,3,4-tetrahydroisoquinoline and morpholine derived carbazates, yielded inhibitors of the catalytic activity of this enzyme with nanomolar potency. (C) 2004 Elsevier Ltd. All rights reserved.