2-chloro-2-phenyl-propionic acid amide | 52839-80-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-2-phenyl-propionic acid amide
• 英文别名: 2-Chlor-2-phenyl-propionsaeure-amid；2-methyl-N-phenyl chloroacetamide；2-Chloro-2-phenylpropanamide
• CAS: 52839-80-2
• 化学式: C₉H₁₀ClNO
• 分子量: 183.637
• InChiKey: OUMRLAKCQBFNEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-二氯苯酚 、 2,6-二氯-N-苯基苯胺 、 2-chloro-2-phenyl-propionic acid amide 在 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 以72.7%的产率得到双氯芬酸杂质16
  参考文献：
  名称：

  Method for the preparation of substituted derivatives of diphenyl amine

  摘要：

  这一发明提供了一种新型的制备二苯胺取代衍生物的过程。这一新型过程的特点是使用成本低廉且可回收的酚盐作为催化剂，进行分子重排和胺解反应，以高产率获得二苯胺取代衍生物。

  公开号：

  US05475139A1
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氨 作用下， 生成 2-chloro-2-phenyl-propionic acid amide
  参考文献：
  名称：

  The Stereochemistry of Raney Nickel Action. VI. Functional Group Hydrogenolyses in the α-Substituted α-Phenylpropionic Acid Series

  摘要：

  DOI：

  10.1021/ja01594a068

文献信息

• 8-Hydroxyquinoline compounds and methods thereof
  申请人：Bursavich Matthew G.

  公开号：US20080269213A1

  公开（公告）日：2008-10-30

  The present invention relates to 8-Hydroxyquinoline Compounds; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, malignant neoplasm, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of an 8-Hydroxyquinoline Compound to a mammal in need thereof.

  本发明涉及8-羟基喹啉化合物；包含一种8-羟基喹啉化合物的组合物；以及治疗或预防金属蛋白酶相关疾病的方法，例如关节炎、骨关节炎、恶性肿瘤、类风湿性关节炎、哮喘、慢性阻塞性肺病、动脉粥样硬化、年龄相关性黄斑变性、心肌梗死、角膜溃疡、眼表疾病、肝炎、主动脉瘤、肌腱炎、中枢神经系统疾病、异常伤口愈合、血管生成、再狭窄、肝硬化、多发性硬化症、肾小球肾炎、移植物抗宿主病、糖尿病、炎性肠病、休克、椎间盘退化、中风、骨质疏松或牙周疾病；或者包括向需要的哺乳动物施用有效剂量的8-羟基喹啉化合物。
• Polymer production method and radical polymerization initiating group-containing compound
  申请人：DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD.

  公开号：US10982033B2

  公开（公告）日：2021-04-20

  The present invention provides: a novel production technique that enables production of a polymer whose molecular weight and molecular weight distribution are controlled and production of a polymer having a complicated structure in a desirably controlled manner using commercially available materials without using a radical polymerization initiator or a special material for use in living radical polymerization and without the need for strict polymerization conditions; and a radical polymerization initiating group-containing compound for use in the technique. The present invention relates to: a method for producing a polymer, the method including a polymerization step of mixing and warming (1) a radically polymerizable monomer, (2) an organic compound wherein at least one group that functions as a group for initiating polymerization of the monomer and that has a structure represented by formula 1 or formula 2 (X in the formula represents Cl or Br) is introduced in a molecule of the organic compound, and (3) an iodine-containing compound, thereby initiating, from the group having the structure, radical polymerization accompanied by a termination reaction; and the organic compound of (2) for use in the method.

  本发明提供了：一种新型生产技术，该技术可使用市售材料，无需使用自由基聚合引发剂或用于活自由基聚合的特殊材料，也无需严格的聚合条件，即可生产出分子量和分子量分布可控的聚合物，并以理想的可控方式生产出具有复杂结构的聚合物；以及一种用于该技术的含自由基聚合引发基团的化合物。本发明涉及一种生产聚合物的方法，该方法包括以下聚合步骤：将(1)可自由基聚合的单体；(2)有机化合物，其中在有机化合物分子中引入至少一个可作为单体聚合引发基团的基团，该基团具有式 1 或式 2 所代表的结构（式中的 X 代表 Cl 或 Br）；(3)含碘化合物，从而从具有该结构的基团引发伴随终止反应的自由基聚合；以及 (2) 中的有机化合物用于该方法。
• JPH05320096A
  申请人：——

  公开号：JPH05320096A

  公开（公告）日：1993-12-03
• POLYMER PRODUCTION METHOD AND RADICAL POLYMERIZATION INITIATING GROUP-CONTAINING COMPOUND
  申请人：DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD.

  公开号：US20190002619A1

  公开（公告）日：2019-01-03

  The present invention provides: a novel production technique that enables production of a polymer whose molecular weight and molecular weight distribution are controlled and production of a polymer having a complicated structure in a desirably controlled manner using commercially available materials without using a radical polymerization initiator or a special material for use in living radical polymerization and without the need for strict polymerization conditions; and a radical polymerization initiating group-containing compound for use in the technique. The present invention relates to: a method for producing a polymer, the method including a polymerization step of mixing and warming (1) a radically polymerizable monomer, (2) an organic compound wherein at least one group that functions as a group for initiating polymerization of the monomer and that has a structure represented by formula 1 or formula 2 (X in the formula represents Cl or Br) is introduced in a molecule of the organic compound, and (3) an iodine-containing compound, thereby initiating, from the group having the structure, radical polymerization accompanied by a termination reaction; and the organic compound of (2) for use in the method.
• US7947712B2
  申请人：——

  公开号：US7947712B2

  公开（公告）日：2011-05-24