4-[(1,10-dimethyl-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)-acetyl]-morpholine | 56220-71-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-[(1,10-dimethyl-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)-acetyl]-morpholine
• 英文别名: 2-(1,10-Dimethyl-3,4-dihydro-[1,4]oxazino[4,3-a]indol-1-yl)-1-morpholin-4-ylethanone
• CAS: 56220-71-4
• 化学式: C₁₉H₂₄N₂O₃
• 分子量: 328.411
• InChiKey: YCNFLKJYNWRSAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  43.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-[(1,10-dimethyl-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)-acetyl]-morpholine 、 氢化铝锂 以80%的产率得到
  参考文献：
  名称：

  DEMERSON C. A.; SANTROCH G.; HUMBER L. G.; CHAREST M.-P., J. MED. CHEM. , 1975, 18, NO 6, 577-580

  摘要：

  DOI：
• 作为产物：
  描述：

  3,4-Dihydro-1,10-dimethyl-1H-1,4-oxazino[4,3-a]-indole-1-acetic acid 、 吗啉 生成 4-[(1,10-dimethyl-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)-acetyl]-morpholine
  参考文献：
  名称：

  3,4-Dihydro-1H-1,4-oxazino[4,3-a]indoles as potential antidepressants

  摘要：

  A series of 3,4-dihydro-1H-1,4-oxazino[4,3-a]indoles bearing basic side chains has been synthesized by a novel chemical process. These compounds have been screened for potential antidepressant activity. One of these derivatives, 3,4-dihydro-1,10-dimethyl-1-(3-methylaminopropyl)-1H-1,4-oxazino[4,3-a]indole (AY-23,673), was particularly potent in the prevention of reserpine ptosis test in mice, with an ED50 of 0.5 mg/kg ip.

  DOI：

  10.1021/jm00240a010

文献信息

• US3962236A
  申请人：——

  公开号：US3962236A

  公开（公告）日：1976-06-08
• US4012511A
  申请人：——

  公开号：US4012511A

  公开（公告）日：1977-03-15
• US4066763A
  申请人：——

  公开号：US4066763A

  公开（公告）日：1978-01-03
• 3,4-Dihydro-1H-1,4-oxazino[4,3-a]indoles as potential antidepressants
  作者：Christopher A. Demerson、George Santroch、Leslie G. Humber、Marie P. Charest

  DOI：10.1021/jm00240a010

  日期：1975.6

  A series of 3,4-dihydro-1H-1,4-oxazino[4,3-a]indoles bearing basic side chains has been synthesized by a novel chemical process. These compounds have been screened for potential antidepressant activity. One of these derivatives, 3,4-dihydro-1,10-dimethyl-1-(3-methylaminopropyl)-1H-1,4-oxazino[4,3-a]indole (AY-23,673), was particularly potent in the prevention of reserpine ptosis test in mice, with an ED50 of 0.5 mg/kg ip.
• DEMERSON C. A.; SANTROCH G.; HUMBER L. G.; CHAREST M.-P., J. MED. CHEM. <JMCM-AR>, 1975, 18, NO 6, 577-580
  作者：DEMERSON C. A.、 SANTROCH G.、 HUMBER L. G.、 CHAREST M.-P.

  DOI：——

  日期：——