(2-hydroxy-2'-methoxy-4,4'-di(2-ethoxycarbonylethenyl))diphenyl ether | 515813-57-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-hydroxy-2'-methoxy-4,4'-di(2-ethoxycarbonylethenyl))diphenyl ether
• 英文别名: ethyl (E)-3-[4-[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]-2-methoxyphenoxy]-3-hydroxyphenyl]prop-2-enoate
• CAS: 515813-57-7
• 化学式: C₂₃H₂₄O₇
• 分子量: 412.439
• InChiKey: CFCLSXMHGMKGCU-QHKWOANTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (2-hydroxy-2'-methoxy-4,4'-di(2-ethoxycarbonylethenyl))diphenyl ether 在 lithium aluminium tetrahydride 、 三氯化铝 、 甲基磺酰胺 、 AD-mix-β 、 potassium carbonate 作用下， 以 四氢呋喃 、 水 、 丙酮 、 叔丁醇 为溶剂， 反应 26.5h， 生成 (R,R)-2,2'-dimethoxy-4-(3-hydroxy-1-propenyl)-4'-(1,2,3-trihydroxypropyl)diphenyl ether
  参考文献：
  名称：

  Studies on the synthesis of biphenylneolignans. Part 1: Enantioselective synthesis of (S,S)- and (R,R)-2,2′-dimethoxy-4-(3-hydroxy-1-propenyl)-4′-(1,2,3-trihydroxypropyl)diphenyl ether

  摘要：

  Two erythro-isomers of 2,2'-dimethoxy-4-(3-hydroxy-1-propenyl)-4'-(I, 2,3 -trihydroxypropyl)diphenyl ether, (7'S, 8'S)-9 and (7'R, 8'R)-9, were synthesized in seven steps, in which an improved method for the synthesis of the key intermediate 3 was developed. The absolute configuration of the target molecules was also confirmed. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00742-5
• 作为产物：
  描述：

  4-氟-3-硝基苯甲醛 在 哌啶 、 吡啶 、 硫酸 、 四丁基氯化铵 、 铁粉 、 potassium carbonate 、 iron(II) sulfate 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 10.16h， 生成 (2-hydroxy-2'-methoxy-4,4'-di(2-ethoxycarbonylethenyl))diphenyl ether
  参考文献：
  名称：

  Studies on the synthesis of biphenylneolignans. Part 1: Enantioselective synthesis of (S,S)- and (R,R)-2,2′-dimethoxy-4-(3-hydroxy-1-propenyl)-4′-(1,2,3-trihydroxypropyl)diphenyl ether

  摘要：

  Two erythro-isomers of 2,2'-dimethoxy-4-(3-hydroxy-1-propenyl)-4'-(I, 2,3 -trihydroxypropyl)diphenyl ether, (7'S, 8'S)-9 and (7'R, 8'R)-9, were synthesized in seven steps, in which an improved method for the synthesis of the key intermediate 3 was developed. The absolute configuration of the target molecules was also confirmed. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00742-5

文献信息

• Studies on the synthesis of biphenylneolignans. Part 1: Enantioselective synthesis of (S,S)- and (R,R)-2,2′-dimethoxy-4-(3-hydroxy-1-propenyl)-4′-(1,2,3-trihydroxypropyl)diphenyl ether
  作者：Yi Yang、Chenglu Zhang、Guoren Yue、Pingyan Bie、Xinfu Pan

  DOI：10.1016/s0957-4166(02)00742-5

  日期：2002.12

  Two erythro-isomers of 2,2'-dimethoxy-4-(3-hydroxy-1-propenyl)-4'-(I, 2,3 -trihydroxypropyl)diphenyl ether, (7'S, 8'S)-9 and (7'R, 8'R)-9, were synthesized in seven steps, in which an improved method for the synthesis of the key intermediate 3 was developed. The absolute configuration of the target molecules was also confirmed. (C) 2002 Published by Elsevier Science Ltd.