2-羟基-2,4,4-三甲基戊酸 | 5438-26-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-羟基-2,4,4-三甲基戊酸
• 英文名称: 2-hydroxy-2,4,4-trimethyl-valeric acid
• 英文别名: 2-Hydroxy-2,4,4-trimethyl-valeriansaeure；4-Hydroxy-2.2.4-trimethyl-pentansaeure-(5)；C-Methyl-C-neopentyl-glykolsaeure；β-Oxy-δ.δ-dimethyl-pentan-β-carbonsaeure；α-Oxy-α.γ.γ-trimethyl-n-valeriansaeure；2.2.4-Trimethyl-pentanol-(4)-saeure-(5)；2-Hydroxy-2,4,4-trimethylpentanoic acid
• CAS: 5438-26-6
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: ZRGZOSVVPXKTRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙醇 、 2-羟基-2,4,4-三甲基戊酸 在 盐酸 作用下， 生成 2-hydroxy-2,4,4-trimethyl-valeric acid ethyl ester
  参考文献：
  名称：

  5,5-Dialkyl-2,4-oxazolidinediones^1,2

  摘要：

  DOI：

  10.1021/ja01854a019
• 作为产物：
  描述：

  异辛烯 在 potassium permanganate 、 水 作用下， 生成 2-羟基-2,4,4-三甲基戊酸
  参考文献：
  名称：

  Butlerow, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1882, vol. 14, p. 204

  摘要：

  DOI：

文献信息

• Thermal dye sublimation transfer receiving element
  申请人：AGFA-GEVAERT naamloze vennootschap

  公开号：EP0481130A1

  公开（公告）日：1992-04-22

  Dye-image receiving element for use according to thermal dye sublimation transfer comprising a support having thereon a dye-image receiving layer containing a (co)polyester comprising condensation residues of one or more diols and one or more dicarboxylic acids and further comprising condensation residues of one or more hydroxy-carboxylic acids containing a long chain alkyl or alkylene group having at least 8 carbon atoms.

  用于热染料升华转移的染料图像接收元件，包括一个支架，支架上有一个染料图像接收层，染料图像接收层含有一种（共）聚酯，该聚酯由一种或多种二元醇和一种或多种二羧酸的缩合残留物组成，还包括一种或多种羟基羧酸的缩合残留物，该羟基羧酸含有至少 8 个碳原子的长链烷基或亚烷基。
• Catalyst for polymerization and copolymerization of ethylene
  申请人：——

  公开号：US20030032551A1

  公开（公告）日：2003-02-13

  A solid titanium complex catalyst for polymerization and copolymerization of ethylene is prepared by the process comprising: (1) preparing a magnesium solution by reacting a halogenated magnesium compound with an alcohol; (2) reacting the magnesium solution with an ester compound having at least one hydroxyl group and a silicon compound having an alkoxy group to produce a magnesium composition; and (3) producing a solid titanium catalyst through recrystallization by reacting the magnesium composition solution with a mixture of a titanium compound and a haloalkane compound; and optionally reacting the solid titanium catalyst with an additional titanium compound. The solid titanium complex catalyst for polymerization and copolymerization of ethylene according to present invention exhibits high catalytic activity, high hydrogen reactivity and controlled particle size, and can advantageously used in the polymerization and copolymerization of ethylene to produce polymers of high bulk density.

  一种用于乙烯聚合和共聚的固体钛络合物催化剂的制备过程包括(1) 将卤代镁化合物与醇反应制备镁溶液；(2) 将镁溶液与具有至少一个羟基的酯化合物和具有一个烷氧基的硅化合物反应制备镁组合物；(3) 将镁组合物溶液与钛化合物和卤代烃化合物的混合物反应，通过重结晶制备固体钛催化剂；还可选择将固体钛催化剂与另外一种钛化合物反应。根据本发明，用于乙烯聚合和共聚的固体钛复合催化剂具有高催化活性、高氢反应活性和可控粒径，可用于乙烯的聚合和共聚以生产高体积密度的聚合物。
• Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
  申请人：——

  公开号：US20040142857A1

  公开（公告）日：2004-07-22

  The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as cancer or viral infections.

  本发明提供了吉西他滨原药、制作吉西他滨原药的方法、吉西他滨原药的药物组合物以及使用吉西他滨原药及其药物组合物治疗或预防癌症或病毒感染等疾病或紊乱的方法。
• Graham et al., Journal of the Chemical Society, 1954, p. 2180,2190
  作者：Graham et al.

  DOI：——

  日期：——
• Hydroxamic acid derivatives and pharmaceutical compositions thereof
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0575844B1

  公开（公告）日：1998-01-21