[(5-bromo-1H-indol-3-yl)-(3-methoxyphenyl)-methyl]-methyl-phenyl-amine | 1173282-84-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [(5-bromo-1H-indol-3-yl)-(3-methoxyphenyl)-methyl]-methyl-phenyl-amine
• 英文别名: [(5-bromo-1H-indol-3-yl)(3-methoxy-phenyl)methyl]-methyl-phenyl-amine；N-[(5-bromo-1H-indol-3-yl)-(3-methoxyphenyl)methyl]-N-methylaniline
• CAS: 1173282-84-2
• 化学式: C₂₃H₂₁BrN₂O
• 分子量: 421.337
• InChiKey: QJIPRAZBFYXBLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  28.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-溴吲哚 、 以 甲苯 为溶剂， 生成 [(5-bromo-1H-indol-3-yl)-(3-methoxyphenyl)-methyl]-methyl-phenyl-amine
  参考文献：
  名称：

  Iron mediated one pot three component synthesis of 3-substituted indoles via aerobic iminium ion formation

  摘要：

  An efficient and economical method was developed for the synthesis of 3 substituted indoles by a highly efficient one-pot three component coupling reaction of substituted or unsubstituted benzyl alcohol, N-methyl aniline or pyrrolidine, and indoles or substituted indoles. (C) 2015 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2015.12.047

文献信息

• Cellulose–Sulfonic Acid: An Efficient, Recyclable, and Biodegradable Solid Acid Catalyst for the Synthesis of 3-Aminoalkylindoles
  作者：S. Satyanarayana、K. Praveen Kumar、P. Lakshmi Reddy、R. Narender、G. Narasimhulu、B. V. Subba Reddy

  DOI：10.1246/cl.130370

  日期：2013.9.5

  Three-component coupling (3CC) of indoles, aldehydes, and N-alkylanilines has been accomplished using a catalytic amount of cellulose–sulfonic acid under mild reaction conditions to furnish the 3-a...

  在温和的反应条件下，使用催化量的纤维素-磺酸完成了吲哚、醛和 N-烷基苯胺的三组分偶联 (3CC)，以提供 3-a...
• One-pot three-component coupling reaction: solvent-free synthesis of novel 3-substituted indoles catalyzed by PMA–SiO2
  作者：P. Srihari、Vinay K. Singh、Dinesh C. Bhunia、J.S. Yadav

  DOI：10.1016/j.tetlet.2009.02.176

  日期：2009.7

  Solvent-free PMA–SiO2-catalyzed synthesis of 3-substituted indole derivatives by a one-pot three-component coupling reaction between aldehyde, N-methyl aniline and indole is described.

  描述了无溶剂的PMA-SiO 2催化醛，N-甲基苯胺和吲哚之间的一锅三组分偶联反应，合成了3-取代的吲哚衍生物。
• Iron mediated one pot three component synthesis of 3-substituted indoles via aerobic iminium ion formation
  作者：Vinay K. Singh、Laxmi Kant Sharma、Rana Krishna Pal Singh

  DOI：10.1016/j.tetlet.2015.12.047

  日期：2016.1

  An efficient and economical method was developed for the synthesis of 3 substituted indoles by a highly efficient one-pot three component coupling reaction of substituted or unsubstituted benzyl alcohol, N-methyl aniline or pyrrolidine, and indoles or substituted indoles. (C) 2015 Published by Elsevier Ltd.