N-(Indan-1-yl)-4-nitro-3-pyridinamine-1-oxide | 133093-63-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: N-(Indan-1-yl)-4-nitro-3-pyridinamine-1-oxide
• 英文别名: N-(2,3-dihydro-1H-inden-1-yl)-4-nitro-1-oxidopyridin-1-ium-3-amine
• CAS: 133093-63-7
• 化学式: C₁₄H₁₃N₃O₃
• 分子量: 271.276
• InChiKey: OSCPIHWRPPTMHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  83.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氟-4-硝基-N-氧化吡啶 、 1-氨基茚满 在 solid 、 silica 、 乙酸乙酯 、 二氯甲烷 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以to give 9.2 g solid, m.p. 137°-138°的产率得到N-(Indan-1-yl)-4-nitro-3-pyridinamine-1-oxide
  参考文献：
  名称：

  Heteroarylamino-and heteroaryloxypyridinamines and related compounds

  摘要：

  描述了一种化合物的公式，其中n为0或1；X为O或NR.sub.2，其中R.sub.2为氢，低烷基或低烷基羰基；R为氢，低烷基，芳基低烷基或低烷基羰基；R.sub.1为##STR2##其中R.sub.3为氢，低烷基或低烷基羰基；m为1或2；每个R.sub.4独立地为氢或低烷基；Y为氢，卤素，低烷基，低烷氧基或三氟甲基。这些化合物可用作局部抗炎剂，治疗各种皮肤病。

  公开号：

  US05034403A1

文献信息

• Heteroarylamino- and heteroaryloxypyridinamine compounds which have
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US04970219A1

  公开（公告）日：1990-11-13

  There are described compounds of the formula ##STR1## where n is 0 or 1; X is O or NR.sub.2,R.sub.2 being hydrogen, loweralkyl or loweralkylcarbonyl; R is hydrogen, loweralkyl, arylloweralkyl or loweralkylcarbonyl; and R.sub.1 is ##STR2## wherein R.sub.3 is hydrogen, loweralkyl or loweralkylcarbonyl; which compounds are useful as topical antiinflammatory agents for the treatment of various dermatoses.

  描述了具有以下式的化合物##STR1##其中n为0或1；X为O或NR.sub.2，R.sub.2为氢、低烷基或低烷基羰基；R为氢、低烷基、芳基低烷基或低烷基羰基；R.sub.1为##STR2##其中R.sub.3为氢、低烷基或低烷基羰基；这些化合物可用作治疗各种皮肤病的局部抗炎药。
• Heteroarylamino- and heteroaryloxypyridinamine compounds which are
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US04983615A1

  公开（公告）日：1991-01-08

  There are described compounds of the formula ##STR1## where n is 0 or 1; X is O or NR.sub.2, R.sub.2 being hydrogen, loweralkyl or loweralkylcarbonyl; R is hydrogen, loweralkyl, arylloweralkyl or loweralkylcarbonyl; and R.sub.1 is ##STR2## wherein R.sub.3 is hydrogen, loweralkyl or loweralkylcarbonyl; m is 1 or 2; each R.sub.4 is independently hydrogen or loweralkyl; and Y is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl; which compounds are useful as topical antiinflammatory agents for the treatment of various dermatoses.

  描述了以下化合物，其化学式为##STR1## 其中n为0或1；X为O或NR.sub.2，R.sub.2为氢、较低烷基或较低烷基羰基；R为氢、较低烷基、芳基较低烷基或较低烷基羰基；R.sub.1为##STR2## 其中R.sub.3为氢、较低烷基或较低烷基羰基；m为1或2；每个R.sub.4独立地为氢或较低烷基；Y为氢、卤素、较低烷基、较低烷氧基或三氟甲基；这些化合物可用作治疗各种皮肤病的局部抗炎药。
• Certain nitro-3-pyrinamines and 3-oxy-analogues
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US05405856A1

  公开（公告）日：1995-04-11

  There are described compounds of the formula ##STR1## where n is 0 or 1; X is O or NR.sub.2, R.sub.2 being hydrogen, loweralkyl or loweralkylcarbonyl; R is hydrogen, loweralkyl, arylloweralkyl or loweralkylcarbonyl; and R.sub.1 is ##STR2## wherein R.sub.3 is hydrogen, loweralkyl or loweralkylcarbonyl; m is 1 or 2; each R.sub.4 is independently hydrogen or loweralkyl; and Y is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl; which compounds are useful as topical antiinflammatory agents for the treatment of various dermatoses.

  描述了一种化合物的公式##STR1##其中n为0或1；X为O或NR.sub.2，其中R.sub.2为氢，低碳基或低碳基羰基；R为氢，低碳基，芳基低碳基或低碳基羰基；而R.sub.1为##STR2##其中R.sub.3为氢，低碳基或低碳基羰基；m为1或2；每个R.sub.4独立地为氢或低碳基；而Y为氢，卤素，低碳基，低碳氧基或三氟甲基。这些化合物可用作局部抗炎剂，用于治疗各种皮肤病。
• Heteroarylamino- and heteroaryloxypyridinamines and related compounds
  申请人：Hoechst-Roussel Pharmaceuticals Incorporated

  公开号：US05221682A1

  公开（公告）日：1993-06-22

  There are described compounds of the formula ##STR1## where n is 0 or 1; X is O or NR.sub.2, R.sub.2 being hydrogen, loweralkyl or loweralkylcarbonyl; R is hydrogen, loweralkyl, arylloweralkyl or loweralkylcarbonyl; and R.sub.1 is ##STR2## wherein R.sub.3 is hydrogen, loweralkyl or loweralkylcarbonyl; m is 1 or 2; each R.sub.4 is independently hydrogen or loweralkyl; and Y is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl; which compounds are useful as topical antiinflammatory agents for the treatment of various dematoses.

  描述了一些化合物的公式，其中n为0或1；X为O或NR.sub.2，其中R.sub.2为氢，低碳烷基或低碳烷基羰基；R为氢，低碳烷基，芳基低碳烷基或低碳烷基羰基；R.sub.1为##STR2## 其中R.sub.3为氢，低碳烷基或低碳烷基羰基；m为1或2；每个R.sub.4独立地为氢或低碳烷基；Y为氢，卤素，低碳烷基，低碳氧基或三氟甲基。这些化合物可用作局部抗炎药物，用于治疗各种皮肤病。
• Heteroarylamino- and heteroaryloxypyridinamines and related compounds, a process for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0405425A2

  公开（公告）日：1991-01-02

  There are described compounds of the formula where n is 0 or 1; X is O or NR₂, R₂ being hydrogen, loweralkyl or loweralkylcarbonyl; Z is NO₂ or NHR where R is hydrogen, loweralkyl, arylloweralkyl or loweralkylcarbonyl; and R₁ is wherein R₃ is hydrogen, loweralkyl or loweralkylcarbonyl; m is 1 or 2; each R₄ is independently hydrogen or loweralkyl; and Y is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl; which compounds are useful as topical antiinflammatory agents for the treatment of various dermatoses.

  其中 n 为 0 或 1；X 为 O 或 NR₂，R₂ 为氢、低级烷基或低级烷基羰基；Z 为 NO₂ 或 NHR，其中 R 为氢、低级烷基、芳基低级烷基或低级烷基羰基；R₁ 为其中 R₃ 为氢、低级烷基或低级烷基羰基； m 为 1 或 2；每个 R₄ 独立地为氢或低级烷基；以及 Y 为氢、卤素、低级烷基、低级烷氧基或三氟甲基；这些化合物可用作治疗各种皮肤病的局部消炎剂。