2,4-dibromo-benzenesulfonic acid amide | 858498-82-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dibromo-benzenesulfonic acid amide
• 英文别名: 2.4-Dibrom-benzolsulfonamid-(1)；2,4-Dibrom-benzolsulfonsaeure-amid；2,4-Dibromobenzenesulfonamide
• CAS: 858498-82-5
• 化学式: C₆H₅Br₂NO₂S
• 分子量: 314.985
• InChiKey: MUFCRRXQXOUBEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-dibromo-benzenesulfonic acid amide 在 copper(l) iodide 、 N,N'-二甲基乙二胺 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 6-bromo-5,5-dioxo-1H,2H,3H-benzo[e]pyrrolo[2,1-c][1,2,4]thiadiazine
  参考文献：
  名称：

  Facile Synthesis of 4H-1,2,4-Benzothiadiazine-1,1-dioxides

  摘要：

  [image omitted] o-Bromoarylsulfonylated amidines prepared either by acylation of amidine with o-bromoarylsulfonyl chloride or through the reaction of o-bromoarylsulfoamide with lactime ether underwent Cu(I)-catalyzed intramolecular cyclization to give 4H-1,2,4-benzothiadiazine-1,1-dioxides in good yield. By varying substituents on arylsulfonyl moieties, amidines, and lactime ethers, a small library of structurally diverse 4H-1,2,4-benzothiadiazine-1,1-dioxide derivatives was prepared.

  DOI：

  10.1080/00397911.2010.494815
• 作为产物：
  描述：

  1,3-二溴苯 在 chlorosulphuric acid 作用下， 生成 2,4-dibromo-benzenesulfonic acid amide
  参考文献：
  名称：

  Identification of Organic Compounds. I. Chlorosulfonic Acid as a Reagent for the Identification of Aryl Halides

  摘要：

  DOI：

  10.1021/ja01860a014

文献信息

• Synthesis and antihyperglycemic evaluation of new 2,4-thiazolidinediones having biodynamic aryl sulfonylurea moieties
  作者：Dhanaji V. Jawale、Umesh R. Pratap、Neha Rahuja、Arvind K. Srivastava、Ramrao A. Mane

  DOI：10.1016/j.bmcl.2011.10.110

  日期：2012.1

  New 2,4-thiazolidinediones with aryl sulfonylurea moieties 8a–h have been synthesized by condensing various substituted sulfonamides and 5-(isocyanatomethyl) thiazolidino-2,4-dione 6. The isocyanomethyl thiazolidinedione was obtained by using the Curtius rearrangement, starting from known 2,4-dioxo-5-thiazolidineacetic acid 4. The newly synthesized compounds 8a–h have been evaluated for the antihyperglycemic

  通过缩合各种取代的磺酰胺和5-（异氰酸根合甲基）噻唑烷二-2,4-二酮6合成了具有芳基磺酰脲部分8a - h的新2,4-噻唑烷二酮。异氰基甲基噻唑烷二酮是通过使用Curtius重排法从已知的2,4-二氧-5-噻唑烷乙酸4开始获得的。已经评估了新合成的化合物8a - h在正常大鼠模型中的抗降血糖活性，其中这些化合物8b，8c，8e和8f在负载蔗糖的大鼠模型中显示出显着的降血糖活性。
• Baessmann, Justus Liebigs Annalen der Chemie, 1878, vol. 191, p. 206
  作者：Baessmann

  DOI：——

  日期：——
• Facile Synthesis of 4<i>H</i>-1,2,4-Benzothiadiazine-1,1-dioxides
  作者：Artem Cherepakha、Vladimir O. Kovtunenko、Andrey Tolmachev、Oleg Lukin、Konstantin G. Nazarenko

  DOI：10.1080/00397911.2010.494815

  日期：2011.7.1

  [image omitted] o-Bromoarylsulfonylated amidines prepared either by acylation of amidine with o-bromoarylsulfonyl chloride or through the reaction of o-bromoarylsulfoamide with lactime ether underwent Cu(I)-catalyzed intramolecular cyclization to give 4H-1,2,4-benzothiadiazine-1,1-dioxides in good yield. By varying substituents on arylsulfonyl moieties, amidines, and lactime ethers, a small library of structurally diverse 4H-1,2,4-benzothiadiazine-1,1-dioxide derivatives was prepared.
• Identification of Organic Compounds. I. Chlorosulfonic Acid as a Reagent for the Identification of Aryl Halides
  作者：Ernest H. Huntress、Frederick H. Carten

  DOI：10.1021/ja01860a014

  日期：1940.3