(2R,3R)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-2-fluoro-3-(2-fluorophenyl)butanoate | 1346145-55-8
中文名称
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中文别名
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英文名称
(2R,3R)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-2-fluoro-3-(2-fluorophenyl)butanoate
英文别名
ethyl (2R,3R)-3-(((R)-tert-butylsulfinyl)amino)-2-fluoro-3-(2-fluorophenyl)butanoate；ethyl (2R,3R)-3-[[(R)-tert-butylsulfinyl]amino]-2-fluoro-3-(2-fluorophenyl)butanoate
CAS
1346145-55-8
化学式
C16H23F2NO3S
mdl
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分子量
347.426
InChiKey
POTDMDFAXMUOKF-IBRHDDFTSA-N
BEILSTEIN
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EINECS
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
物化性质
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沸点：453.7±55.0 °C(Predicted)
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密度：1.210±0.06 g/cm3(Predicted)
计算性质
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辛醇/水分配系数(LogP)：3.2
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重原子数：23
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可旋转键数：8
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环数：1.0
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sp3杂化的碳原子比例：0.56
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拓扑面积：74.6
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氢给体数：1
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氢受体数：7
上下游信息
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下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— (R)-2-methylpropane-2-sulfinic acid [(1R,2R)-2-fluoro-1-(2-fluorophenyl)-3-hydroxy-1-methylpropyl]amide 1346145-59-2 C14H21F2NO2S 305.389 S(R)]-N-[(1R,2R)-2-氟-1-(2-氟苯基)-1-甲基-3-氧代丙基]-2-甲基-2-丙烷亚磺酰胺 (R)-N-((2R,3R)-3-fluoro-2-(2-fluorophenyl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide 1432511-83-5 C14H19F2NO2S 303.373 —— (R)-N-((2R,3R,4S)-3-fluoro-2-(2-fluorophenyl)-4,5-dihydroxypentan-2-yl)-2-methylpropane-2-sulfinamide 1606166-16-8 C15H23F2NO3S 335.415 —— (R)-2-methyl-N-((2R,3R,4S)-3,5,5,5-tetrafluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinamide 1432511-87-9 C15H20F5NO2S 373.387 —— (R)-2-methyl-N-((2R,3R,4R)-3,5,5,5-tetrafluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinamide 1432511-86-8 C15H20F5NO2S 373.387 —— (R)-N-((2R,3S)-3-fluoro-2-(2-fluorophenyl)pent-4-en-2-yl)-2-methylpropane-2-sulfinamide 1606166-15-7 C15H21F2NOS 301.401 —— (5R,6R)-6-fluoro-5-(2-fluorophenyl)-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine 1346145-83-2 C12H14F2N2O 240.253 —— (5R,6R)-5-(5-amino-2-fluorophenyl)-6-fluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine 1346145-95-6 C12H15F2N3O 255.267 —— (4R,5R,6S)-5-fluoro-4-(2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 1432511-93-7 C12H11F5N2O 294.224 —— (4R,5R,6R)-5-fluoro-4-(2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 1432511-92-6 C12H11F5N2O 294.224 —— (4R,5R,6S)-5-fluoro-6-(fluoromethyl)-4-(2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine 1606166-21-5 C12H13F3N2O 258.243 —— (5R,6R)-6-fluoro-5-(2-fluoro-5-nitro-phenyl)-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine 1346145-89-8 C12H13F2N3O3 285.25 —— (4R,5R)-5-fluoro-4-(2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine 1402413-11-9 C11H12F2N2O 226.226 —— (4R,5R,6R)-5-fluoro-4-(2-fluorophenyl)-6-(methoxymethyl)-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine 1606165-68-7 C13H16F2N2O2 270.279 —— (5R,6R)-5-{5-[((4-chloro-1-difluoromethyl-1H-pyrazol-3-yl)methyl)-amino]-2-fluoro-phenyl}-6-fluoro-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine 1400682-60-1 C17H18ClF4N5O 419.809 —— (4R,5R,6S)-4-(5-amino-2-fluorophenyl)-5-fluoro-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 1432511-99-3 C12H12F5N3O 309.239 —— (4R,5R,6R)-4-(5-amino-2-fluorophenyl)-5-fluoro-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 1432511-98-2 C12H12F5N3O 309.239 —— (4R,5R,6S)-5-fluoro-6-(fluoromethyl)-4-(2-fluoro-5-nitrophenyl)-4-methyl-5,6-dihydro-1,3-oxazin-2-amine 1606166-22-6 C12H12F3N3O3 303.241 —— (5R,6R)-5-(5-(3-chloro-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ylamino)-2-fluorophenyl)-6-fluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine 1400682-58-7 C20H21ClF2N4O 406.863 —— N-(3-((4R,5R,6S)-2-amino-5-fluoro-6-(fluoromethyl)-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide 1606164-56-0 C19H16F3N5O2 403.364 —— (4R,5R,6S)-5-fluoro-4-(2-fluoro-5-nitrophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 1432511-96-0 C12H10F5N3O3 339.222 —— (4R,5R,6R)-5-fluoro-4-(2-fluoro-5-nitrophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 1432511-95-9 C12H10F5N3O3 339.222 —— (4R,5R)-4-(5-amino-2-fluorophenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine 1402413-27-7 C11H13F2N3O 241.241 —— (2S,3R,4R)-4-amino-1,1,1,3-tetrafluoro-4-(2-fluorophenyl)pentan-2-ol 1432511-90-4 C11H12F5NO 269.214 —— (2R,3R,4R)-4-amino-1,1,1,3-tetrafluoro-4-(2-fluorophenyl)pentan-2-ol 1432511-89-1 C11H12F5NO 269.214 —— (4R,5R,6R)-N,N-bis(2,4-dimethoxybenzyl)-5-fluoro-4-(2-fluorophenyl)-6-(methoxymethyl)-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine 1606165-67-6 C31H36F2N2O6 570.633 —— (4R,5R)-5-fluoro-4-(2-fluoro-5-nitrophenyl)-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine 1402413-21-1 C11H11F2N3O3 271.223 —— N-(3-((4R,5R,6R)-2-amino-5-fluoro-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide 1432512-01-0 C19H14F5N5O2 439.344 —— N-(3-((4R,5R,6S)-2-amino-5-fluoro-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide 1432512-02-1 C19H14F5N5O2 439.344 —— 5-cyano-pyridine-2-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide 1402412-33-2 C18H15F2N5O2 371.346 - 1
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反应信息
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作为反应物：描述：(2R,3R)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-2-fluoro-3-(2-fluorophenyl)butanoate 在 盐酸 、 lithium aluminium tetrahydride 、 potassium carbonate 、 戴斯-马丁氧化剂 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 6.17h， 生成 (2R,3S)-3-fluoro-2-(2-fluorophenyl)pent-4-en-2-amine参考文献：