1-hydroxy-2-nonadecanone | 90857-71-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-hydroxy-2-nonadecanone
• 英文别名: 1-hydroxynonadecan-2-one
• CAS: 90857-71-9
• 化学式: C₁₉H₃₈O₂
• 分子量: 298.51
• InChiKey: BQJVAYIXUHOVHL-UHFFFAOYSA-N

物化性质

• 沸点：
  323.0±10.0 °C(Predicted)
• 密度：
  0.886±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  21
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-hydroxy-2-nonadecanone 在 sodium tetrahydroborate 、 sodium acetate 、 三乙胺 作用下， 以 异丙醇 为溶剂， 反应 3.5h， 生成 2-bromoethyl 2-hydroxynonadecyl phosphate
  参考文献：
  名称：

  Analogs of platelet activating factor (PAF). 1. Some modifications of the alkoxy chain

  摘要：

  Analogues of platelet activating factor (PAF) in which the ether oxygen has been removed (6) and in which the alkoxy chain at C1 has been replaced with a o-, p-, or m-alkylphenoxy group (30, 31, and 35, respectively) have been prepared. Compound 6 shows reduced platelet aggregation and hypotensive activity in comparison with C16 and C18 PAF. The results obtained for compounds 30, 31, and 35 indicate that the hypotensive and platelet aggregating responses are sensitive to structural modification of the ether chain. The ortho analogue 30 shows no platelet aggregating activity and only a weak hypotensive response. The para analogue 31 exhibits a moderate decrease in activity in both assays. The meta analogue 35 is the most active of the three.

  DOI：

  10.1021/jm00375a016
• 作为产物：
  描述：

  三(三甲基硅氧基)乙烯 、 十八烷酰氯 在 盐酸 作用下， 生成 1-hydroxy-2-nonadecanone
  参考文献：
  名称：

  Analogs of platelet activating factor (PAF). 1. Some modifications of the alkoxy chain

  摘要：

  Analogues of platelet activating factor (PAF) in which the ether oxygen has been removed (6) and in which the alkoxy chain at C1 has been replaced with a o-, p-, or m-alkylphenoxy group (30, 31, and 35, respectively) have been prepared. Compound 6 shows reduced platelet aggregation and hypotensive activity in comparison with C16 and C18 PAF. The results obtained for compounds 30, 31, and 35 indicate that the hypotensive and platelet aggregating responses are sensitive to structural modification of the ether chain. The ortho analogue 30 shows no platelet aggregating activity and only a weak hypotensive response. The para analogue 31 exhibits a moderate decrease in activity in both assays. The meta analogue 35 is the most active of the three.

  DOI：

  10.1021/jm00375a016

文献信息

• Phosphocholine derivatives having antihypertensive action
  申请人：American Cyanamid Company

  公开号：US04640913A1

  公开（公告）日：1987-02-03

  Phosphocholine derivatives and compositions are described which are useful as hypotensive agents and in the treatment of hypertension in warm-blooded animals.

  磷酸胆碱衍生物和组合物被描述为在温血动物中作为降压剂和治疗高血压的有用药物。
• Ink composition, inkjet recording method, method of producing planographic printing plate, and planographic printing plate
  申请人：Nakamura Ippei

  公开号：US20070182786A1

  公开（公告）日：2007-08-09

  The invention provides an ink composition which includes a polymerization initiator, a polymerizable compound, a colorant, and a high molecular compound having a repeating unit represented by the following formula (I). In formula (I), n represents an integer of from 1 to 5.
• SEPARATION OF NATURAL OIL-DERIVED ALDEHYDES OR HYDROXY METHYL ESTERS USING PROCESS CHROMATOGRAPHY
  申请人：Feist Shawn D.

  公开号：US20100331559A1

  公开（公告）日：2010-12-30

  Use process chromatographic apparatus and process (for example, SMB chromatographic separation) to effect removal of at least a portion of components that contain neither a hydroxy moiety nor an aldehyde moiety from a feedstream that includes such components as well as components that contain one or more of a hydroxy moiety and an aldehyde moiety.
• IMPROVED AQUEOUS PIGMENT DISPERSIONS
  申请人：LANDA LABS (2012) LTD.

  公开号：US20200190351A1

  公开（公告）日：2020-06-18

  There are disclosed aqueous pigment dispersions containing dispersant-improving-agents, and methods of preparing and using the same.
• US4640913A
  申请人：——

  公开号：US4640913A

  公开（公告）日：1987-02-03