10-phenyl-undecanoic acid ethyl ester | 36002-36-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 10-phenyl-undecanoic acid ethyl ester
• 英文别名: 10-Phenyl-undecansaeure-aethylester；ethyl 10-phenylundecanoate
• CAS: 36002-36-5
• 化学式: C₁₉H₃₀O₂
• 分子量: 290.446
• InChiKey: WFYMDMMMAPURDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.47
• 重原子数：
  21.0
• 可旋转键数：
  11.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  11-溴代十一烷酸乙酯 在 三氯化铝 、 苯 作用下， 生成 10-phenyl-undecanoic acid ethyl ester
  参考文献：
  名称：

  Fourneau; Baranger, Bulletin de la Societe Chimique de France, 1931, vol. <4> 49, p. 1161,1169

  摘要：

  DOI：

文献信息

• Iodinated Organic Compounds as Contrast Media for Radiographic Diagnoses. I. Iodinated Aracyl Esters^1a
  作者：William H. Strain、John T. Plati、Stafford L. Warren

  DOI：10.1021/ja01258a054

  日期：1942.6
• Fourneau; Baranger, Bulletin de la Societe Chimique de France, 1931, vol. <4>49, p. 1163,1168
  作者：Fourneau、Baranger

  DOI：——

  日期：——
• Elevated plasma free fatty acid concentrations do not modify cardiac repolarization in patients treated by electrolyte-glucose-insulin infusion
  作者：F. Nappo、M. Loreto、G. Giugliano、E. Grella、K. Esposito、B. Lettieri、D. Giugliano

  DOI：10.1007/bf03345073

  日期：2002.7

  Fat emulsion infusion is routinely used as a source of calories and essential fatty acids for critically ill patients who may be at risk for acquired ventricular repolarization alterations due either to drugs or electrolyte disturbances. The aim of this study was to evaluate whether acute elevations of plasma free fatty acid concentrations influence the corrected Q-T interval (Q-Tc), Q-Tc dispersion and sympathetic nervous system activity in patients requiring parenteral nutrition. Thirty hospitalized patients (mean+/-SD: 62 +/- 17 yr of age) requiring total parenteral nutrition received an infusion of 10% (500 ml) triacylglycerol emulsion as a source of calories (450 Kcal); on another occasion, and in random order, the same patients received an infusion of 20% (500 ml) triacylglycerol emulsion (900 Kcal). The infusion lasted 8 h and was preceded by a sc injection of heparin (5000 U). Infusions of both 10% and 20% triacylglycerol emulsion increased plasma free fatty acid (p<0.001) and triacylglycerol (p<0.01) concentrations, and was associated with no significant change in mean BP, heart rate, and plasma catecholamines. At baseline, Q-Tc and Q-Tc dispersion were within the normal range (<440 milliseconds for QTc and <40 ms for QTc-d) and did not show any significant change at any time during infusion of triacylglycerol emulsion at both concentrations. In the setting of a balanced parenteral nutrition, acute elevation of plasma free fatty acid concentrations in critically ill patients do not modify ventricular repolarization. (C) 2002, Editrice Kurtis.