Ethyl 2-(2-oxocyclohexyl)-2-(4-phenylpiperidin-1-yl)acetate | 1314708-14-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ethyl 2-(2-oxocyclohexyl)-2-(4-phenylpiperidin-1-yl)acetate
• 英文别名: ethyl 2-(2-oxocyclohexyl)-2-(4-phenylpiperidin-1-yl)acetate
• CAS: 1314708-14-9
• 化学式: C₂₁H₂₉NO₃
• 分子量: 343.466
• InChiKey: VUZPBTLEDSOFHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-环己烯氧基三甲基硅烷 、 (4-苯基-1-哌啶基)乙酸乙酯 在 1,8-双二甲氨基萘 、 Selectfluor 作用下， 以 乙腈 为溶剂， 反应 0.17h， 以25%的产率得到Ethyl 2-(2-oxocyclohexyl)-2-(4-phenylpiperidin-1-yl)acetate
  参考文献：
  名称：

  The development of a Selectfluor®-mediated oxidative Mannich reaction

  摘要：

  Selectfluor (R) is an easy to handle, air-stable and powerful electrophilic fluorination agent that can be used in a novel oxidative Mannich-type carbon-carbon bond forming process to allylate electron deficient tertiary amines in moderate to good yields. This process is rapid, operationally simple, insensitive to atmospheric conditions and of potentially broad use, especially in the construction of homoallylamines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.012

文献信息

• The development of a Selectfluor®-mediated oxidative Mannich reaction
  作者：Matthew H. Daniels、Jed Hubbs

  DOI：10.1016/j.tetlet.2011.05.012

  日期：2011.7

  Selectfluor (R) is an easy to handle, air-stable and powerful electrophilic fluorination agent that can be used in a novel oxidative Mannich-type carbon-carbon bond forming process to allylate electron deficient tertiary amines in moderate to good yields. This process is rapid, operationally simple, insensitive to atmospheric conditions and of potentially broad use, especially in the construction of homoallylamines. (C) 2011 Elsevier Ltd. All rights reserved.