1-(3-chloro-4-methylphenyl)-1H-pyrrole | 142044-87-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-(3-chloro-4-methylphenyl)-1H-pyrrole
• 英文别名: 1-(3-Chloro-4-methylphenyl)pyrrole
• CAS: 142044-87-9
• 化学式: C₁₁H₁₀ClN
• mdl: MFCD02665246
• 分子量: 191.66
• InChiKey: CGNNQGOLXHUUHO-UHFFFAOYSA-N

物化性质

• 沸点：
  289.9±33.0 °C(Predicted)
• 密度：
  1.11±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2,5-二甲氧基四氢呋喃 、 3-氯-4-甲基苯胺 在 ionic liquid immobilized on γ-Fe₂O₃(at)SiO₂ nanoparticles 作用下， 以 水 为溶剂， 反应 0.83h， 以92%的产率得到1-(3-chloro-4-methylphenyl)-1H-pyrrole
  参考文献：
  名称：

  A recyclable magnetic nanoparticles supported antimony catalyst for the synthesis of N-substituted pyrroles in water

  摘要：

  A new magnetic nanoparticle-supported catalyst for Clauson-Kaas reaction. The corresponding N-substituted pyrroles in by magnetic separation and recycled for antimony catalyst was prepared and evaluated as a recoverable reaction proceeds efficiently in aqueous medium to give the high yield. The immobilized catalyst could be easily recovered six times without significant loss of its catalytic activity. (c) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.apcata.2013.03.005

文献信息

• Azetidine Derivatives
  申请人：NOSSE Bernd

  公开号：US20130172312A1

  公开（公告）日：2013-07-04

  Azetidine derivatives of which the following is exemplary and their use in the treatment of obesity, diabetes or dyslipidemia.

  以下是示例性的氮杂环丙烷衍生物及其在肥胖、糖尿病或血脂异常治疗中的用途。
• Imidazole derivatives, potent and selective antagonists of angiotensin II receptor
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0480204B1

  公开（公告）日：1996-03-20
• US5210092A
  申请人：——

  公开号：US5210092A

  公开（公告）日：1993-05-11
• US5215994A
  申请人：——

  公开号：US5215994A

  公开（公告）日：1993-06-01
• A recyclable magnetic nanoparticles supported antimony catalyst for the synthesis of N-substituted pyrroles in water
  作者：Fei-Ping Ma、Pei-He Li、Bao-Le Li、Li-Ping Mo、Ning Liu、Hui-Jun Kang、Ya-Nan Liu、Zhan-Hui Zhang

  DOI：10.1016/j.apcata.2013.03.005

  日期：2013.4

  A new magnetic nanoparticle-supported catalyst for Clauson-Kaas reaction. The corresponding N-substituted pyrroles in by magnetic separation and recycled for antimony catalyst was prepared and evaluated as a recoverable reaction proceeds efficiently in aqueous medium to give the high yield. The immobilized catalyst could be easily recovered six times without significant loss of its catalytic activity. (c) 2013 Elsevier B.V. All rights reserved.