2-羟基-N,N-二(2-羟基乙基)-乙酰胺 | 17409-41-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-羟基-N,N-二(2-羟基乙基)-乙酰胺
• 英文名称: 2-hydroxy-N,N-bis(2-hydroxyethyl)acetamide
• 英文别名: N,N-bis-(2-hydroxyethyl)-glycolic acid amide；Acetamide, 2-hydroxy-N,N-bis(2-hydroxyethyl)-
• CAS: 17409-41-5
• 化学式: C₆H₁₃NO₄
• mdl: MFCD01753191
• 分子量: 163.174
• InChiKey: AFRFYMZFIJPPDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  81
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  2-羟基-N,N-二(2-羟基乙基)-乙酰胺 、 硼酸三甲酯 以 甲苯 为溶剂， 反应 20.5h， 以29.8 g的产率得到2,8,9-trioxa-5-aza-1-borabicyclo[3.3.3]undecan-4-one
  参考文献：
  名称：

  一类含硼化合物及其在催化氟化反应中的应 用

  摘要：

  本发明涉及精细化工领域，尤其涉及一类含硼化合物及其在催化氟化反应中的应用。采用本发明提供的含硼化合物作为催化剂，可以通过一步温和反应进行氟代，与现有技术比较，氟化反应条件温和，效率高，催化原理新颖，操作简便，污染少，溶剂成本低，适合工业化生产。

  公开号：

  CN108069994B
• 作为产物：
  描述：

  2,2-二甲基-1,3-二氧戊环-4-酮 、 二乙醇胺 以 二氯甲烷 为溶剂， 以15%的产率得到2-羟基-N,N-二(2-羟基乙基)-乙酰胺
  参考文献：
  名称：

  Synthesis and evaluation of in vitro anti-tuberculosis activity of N-substituted glycolamides

  摘要：

  On the basis of the structural similarity of N-substituted glycolamides with N-glycolyl muramic acid residues of the cell wall of Mycobacterium tuberculosis, a series of these compounds were designed and synthesized by the reaction of glycolic acid acetonide 1 (2,2-dimethyl-5-oxo-1,3-dioxolane) with the proper amines. The minimum inhibitory concentration (MIC) was determined against M. tuberculosis H(37)Rv in BACTEC 12B medium, using the Microplate Alamar Blue Assay (MABA). Among the synthesized compounds, all those with disubstituted amide structure accompanied by one or two heteroatom(s) with loan pair(s) of electrons atom(s) P to the amide nitrogen demonstrated moderate anti-tuberculosis activity and all the monosubstituted amides showed no activity at all. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.02.022

文献信息

• COMPOSITIONS AND METHODS FOR REDUCTION OF KETONES, ALDEHYDES AND IMINIUMS, AND PRODUCTS PRODUCED THEREBY
  申请人：Adler Marc J.

  公开号：US20170362151A1

  公开（公告）日：2017-12-21

  A method of producing an alcohol, comprises reducing an aldehyde or a ketone with a hydridosilatrane. The reducing is carried out with an activator.

  生产醇的方法包括使用氢硅氮烷还原醛或酮。还原过程中需要使用活化剂。
• Fluorene Compound and Pharmaceutical Use Thereof
  申请人：Motomura Takahisa

  公开号：US20100240634A1

  公开（公告）日：2010-09-23

  The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.

  本发明提供了一种用于预防或治疗糖尿病、糖尿病并发症、胰岛素抵抗综合征、代谢综合征、高血糖、血脂异常、动脉粥样硬化、心力衰竭、心肌病、心肌缺血、脑缺血、脑卒中、肺动脉高压、高乳酸血症、线粒体疾病、线粒体脑病或癌症的药剂，即PDHK抑制剂等。一种由下式[I]表示的化合物或其药学上可接受的盐，或其溶剂：其中每个符号如规范中所定义。
• Process for controlling antimicrobial activity using glycolic acid
  申请人：The United States of America as represented by the Secretary of

  公开号：US04464392A1

  公开（公告）日：1984-08-07

  A process for using glycolic acid derivatives to control antimicrobial activity is disclosed. The process comprises: Contacting a microbe with an antimicrobial composition containing, as its active ingredient, a member selected from the group consisting of N,N-bis(pelargonoyloxyethyl)pelargonoyloxyacetamide, N,N-bis(lauroyloxyethyl)lauroyloxyacetamide, N,N-bis (oleoyloxyethyl)oleoyloxyacetamide, N,N-bis(trimethylacetyloxyethyl)trimethylacetylacetamide, carboethoxymethyl hydrocinnamate, and bis(carbomethoxymethyl) adipate.

  公开了一种使用乙醇酸衍生物控制抗微生物活性的方法。该过程包括：将微生物与抗微生物组成物接触，该组成物的活性成分为从以下组中选择的成员：N，N-双（癸酸甘油酰氧乙基）癸酰氧乙酰胺，N，N-双（月桂酰氧乙基）月桂酰氧乙酰胺，N，N-双（油酰氧乙基）油酰氧乙酰胺，N，N-双（三甲基乙酰氧乙基）三甲基乙酰基乙酰胺，羟肉桂酸乙酯甲基和双（羧甲氧基甲基）己二酸酯。
• Antimicrobial glycolic acid derivatives
  申请人：The United States of America as represented by the United States

  公开号：US04346043A1

  公开（公告）日：1982-08-24

  Esters and mixed ester-amides derived from glycolic acid by substitution at the hydroxyl and carboxyl functions were prepared by conventional procedures and tested for antimicrobial activity. All of the compounds tested showed some inhibition against four microorganisms under the test conditions, and some of them had potent activity. These new compounds have properties which make it possible for them to be used as biostatic agents in commercial products.

  利用传统方法制备了从乙醇酸的羟基和羧基处取代的酯和混合酯酰胺，并测试了它们的抗微生物活性。在测试条件下，所有测试的化合物都对四种微生物表现出一定的抑制作用，其中一些具有强效活性。这些新化合物具有的特性使它们可以作为商业产品中的生物静态剂使用。
• FLUORENE COMPOUND AND PHARMACEUTICAL USE THEREOF
  申请人：JAPAN TOBACCO INC.

  公开号：US20130274240A1

  公开（公告）日：2013-10-17

  The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.

  本发明提供了一种用于预防或治疗糖尿病、糖尿病并发症、胰岛素抵抗综合征、代谢综合征、高血糖、血脂异常、动脉粥样硬化、心力衰竭、心肌病、心肌缺血、脑缺血、脑卒中、肺动脉高压、高乳酸血症、线粒体病、线粒体脑病或癌症的药剂，即PDHK抑制剂等。其中，化合物由以下式[I]表示，或其药学上可接受的盐或其溶剂：其中，每个符号如规范中所定义。