4-(1-methylethenyl)-benzenemethanol | 6390-64-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(1-methylethenyl)-benzenemethanol
• 英文别名: (4-isopropenylphenyl)methanol；p-Isopropenyl-benzylalkohol；p-Isopropenylbenzylalkohol；Cuminylalkohol；(4-prop-1-en-2-ylphenyl)methanol
• CAS: 6390-64-3
• 化学式: C₁₀H₁₂O
• 分子量: 148.205
• InChiKey: ZQZJRTREIRRSHH-UHFFFAOYSA-N

物化性质

• 沸点：
  74 °C(Press: 2 Torr)
• 密度：
  0.9381 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(1-methylethenyl)-benzenemethanol 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium phosphate 、 偶氮二甲酸二叔丁酯 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 、 水 为溶剂， 反应 21.0h， 生成 5-(2-Hydroxyethyl)-3-[4-[(4-prop-1-en-2-ylphenyl)methoxy]phenyl]-2-pyridin-4-yl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
  参考文献：
  名称：

  [EN] SUBSTITUTED 4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-a]PYRAZINE DERIVATIVES AND 5,6,7,8-TETRAHYDRO-4H-PYRAZOLO[1,5-a][1,4]DIAZEPINE DERIVATIVES AS ROS1 INHIBITORS
  [FR] DÉRIVÉS 4,5,6,7-TÉTRAHYDRO-PYRAZOLO[1,5-A]PYRAZINE SUBSTITUÉS ET DÉRIVÉS 5,6,7,8-TÉTRAHYDRO-4H-PYRAZOLO[1,5-A][1,4]DIAZÉPINE UTILISÉS COMME INHIBITEURS DE ROS1

  摘要：

  本发明涉及取代的4,5,6,7-四氢吡唑并[1,5-a]吡嗪衍生物和5,6,7,8-四氢-4H-吡唑并[1,5-a][1,4]二氮杂环衍生物的公式(I)中的变量具有权利要求中定义的含义。根据本发明的化合物可用作ROS 1抑制剂。本发明还涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物，以及将所述化合物用作药物的用途。

  公开号：

  WO2015144799A1
• 作为产物：
  描述：

  4-异丙基苯甲醇 、 间氯过氧苯甲酸 、 二氯甲烷 生成 4-(1-methylethenyl)-benzenemethanol
  参考文献：
  名称：

  HINO, TOHRU;YAMAGUCHI, HITOSHI;MATSUKI, KENJI;NAKANO, KUMIKO;SODEOKA, MIK+, J. CHEM. SOC. PERKIN TRANS., 1983, N 1, 141-146

  摘要：

  DOI：

文献信息

• Pharmaceutical Compositions Comprising Deuterium-Enriched Perillyl Alcohol, Iso-Perillyl Alcohol and Derivatives Thereof
  申请人：NEONC TECHNOLOGIES INC.

  公开号：US20160039731A1

  公开（公告）日：2016-02-11

  The present invention, provides for a deuterium-enriched monoterpene or sesquiterpene such as perillyl alcohol, or a deuterium-enriched isomer or analog of monoterpenes or sesquiterpenes, such as isoperillyl alcohol. The present invention also provides for a deuterium-enriched derivative of a monoterpene or sesquiterpene, such as a perillyl alcohol carbamate or a deuterium-enriched derivative of an isomer or analog of a monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The deuterium-enriched derivative may be perillyl alcohol or isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a deuterium-enriched compound.

  本发明提供了一种氘增强的单萜或倍半萜，例如桃金娘醇，或者一种氘增强的单萜或倍半萜的同系物或类似物，例如异桃金娘醇。本发明还提供了一种单萜或倍半萜的氘增强衍生物，例如桃金娘醇碳酰胺或一种单萜或倍半萜的同系物或类似物的氘增强衍生物，例如异桃金娘醇碳酰胺。所述氘增强衍生物可以是与治疗剂如化疗剂结合的桃金娘醇或异桃金娘醇。本发明还提供了一种治疗疾病如癌症的方法，包括向患者提供治疗有效量的氘增强化合物。
• [EN] METHODS AND DEVICES FOR USING ISOPERILLYL ALCOHOL<br/>[FR] PROCÉDÉS ET DISPOSITIFS POUR L'UTILISATION D'ALCOOL ISOPERILLYLIQUE
  申请人：NEO ONCOLOGY INC

  公开号：WO2012083178A1

  公开（公告）日：2012-06-21

  The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

  本发明提供了一种治疗疾病的方法，包括向患者施用单萜或倍半萜的异构体或类似物（或其衍生物）的治疗有效量，例如异壬醇。本发明还提供了一种治疗疾病的方法，包括向患者施用单萜或倍半萜的异构体或类似物的衍生物的治疗有效量，例如异壬醇氨基甲酸酯。该衍生物可以是与化疗药物等治疗剂结合的异壬醇。给药途径可以有所不同，包括吸入、鼻内、口服、经皮、静脉、皮下或肌肉注射。
• METHODS AND DEVICES FOR USING ISOPERILLY ALCOHOL
  申请人：Chen Thomas

  公开号：US20130331422A1

  公开（公告）日：2013-12-12

  The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

  本发明提供了一种治疗疾病（如癌症）的方法，包括向患者施用单萜类或倍半萜类（或其衍生物）的异构体或类似物的治疗有效量，例如异柠檬醇。本发明还提供了一种治疗疾病的方法，包括向患者施用单萜类或倍半萜类的异构体或类似物的衍生物的治疗有效量，例如异柠檬醇氨甲酸酯。该衍生物可以是与化疗药物等治疗剂连接的异柠檬醇。给药途径可以各不相同，包括吸入、鼻腔内、口服、经皮、静脉、皮下或肌肉注射。
• METHODS AND DEVICES FOR USING ISOPERILLYL ALCOHOL
  申请人：NEONC TECHNOLOGIES INC.

  公开号：US20150359754A1

  公开（公告）日：2015-12-17

  The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

  本发明提供了一种治疗疾病（如癌症）的方法，包括向患者注射单萜烯或倍半萜烯（或其衍生物）的异构体或类似物，例如异壬醇。本发明还提供了一种治疗疾病的方法，包括向患者注射单萜烯或倍半萜烯（或其衍生物）的异构体或类似物的衍生物，例如异壬醇氨甲酸酯。该衍生物可以与化疗药物等治疗剂结合。给药途径可以各不相同，包括吸入、鼻腔内、口服、经皮、静脉内、皮下或肌肉注射。
• Method for separating nucleic acids by means of liquid chromatography
  申请人：TOSOH CORPORATION

  公开号：EP0964057A1

  公开（公告）日：1999-12-15

  Disclosed is a method for separating nucleic acids by hydrophobic interaction chromatography. The purpose is to provide a method for separating and purifying nucleic acids by hydrophobic interaction chromatography, which enables to separate nucleic acids such as plasmids and DNA fragments in a shorter time.

  本发明公开了一种利用疏水相互作用色谱法分离核酸的方法。其目的是提供一种利用疏水相互作用色谱法分离和纯化核酸的方法，该方法能在较短时间内分离质粒和 DNA 片段等核酸。