3,4-dichloro-1-(2-chlorophenyl)-1H-pyrrole-2,5-dione | 29302-18-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 3,4-dichloro-1-(2-chlorophenyl)-1H-pyrrole-2,5-dione
• 英文别名: 3,4-dichloro-1-(2-chloro-phenyl)-pyrrole-2,5-dione；3,4-Dichlor-1-(2-chlor-phenyl)-pyrrol-2,5-dion；N-(2-Chlorphenyl)-dichlormaleimid；3,4-dichloro-1-(2-chlorophenyl)pyrrole-2,5-dione
• CAS: 29302-18-9
• 化学式: C₁₀H₄Cl₃NO₂
• 分子量: 276.506
• InChiKey: HMABFSHJGPPYEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-甲基哌嗪 、 3,4-dichloro-1-(2-chlorophenyl)-1H-pyrrole-2,5-dione 以 1,4-二氧六环 为溶剂， 生成 3-chloro-1-(2-chlorophenyl)-4-(4-methylpiperazin-1-yl)-1H-pyrrole-2,5-dione
  参考文献：
  名称：

  Inhibition of Bfl-1 with N-aryl maleimides

  摘要：

  High-throughput screening of 66,000 compounds using competitive binding of peptides comprising the BH3 domain to anti-apoptotic Bfl-1 led to the identification of 14 validated 'hits' as inhibitors of Bfl-1. N-Aryl maleimide 1 was among the validated 'hits'. A chemical library encompassing over 280 analogs of 1 was prepared following a two-step synthesis. Structure-activity studies for inhibition of Bfl-1 by analogs of N-aryl maleimide 1 revealed a preference for electron-withdrawing substituents in the N-aryl ring and hydrophilic amines appended to the maleimide core. Inhibitors of Bfl-1 are potential development candidates for anti-cancer therapeutics. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.09.046
• 作为产物：
  描述：

  N-(2-Chlor-phenyl)-succinimid 在 五氯化磷 作用下， 生成 3,4-dichloro-1-(2-chlorophenyl)-1H-pyrrole-2,5-dione
  参考文献：
  名称：

  Sanna; Macciotta, Gazzetta Chimica Italiana, 1927, vol. 57, p. 773

  摘要：

  DOI：

文献信息

• REPELLENT AGAINST AQUATIC ORGANISMS
  申请人：IHARA CHEMICAL INDUSTRY Co., Ltd.

  公开号：EP0010107A1

  公开（公告）日：1980-04-30

  A repellent against aquatic organisms, characterized by comprising as effective ingredients at least one compound of N-arylmaleimide represented by the general formula: Wherein: X, and X2 are the same or different, and denote hydrogen and halogen atoms, respectively; Y is a halogen atom, alkyl group or lower alkoxy group; and n is 0 or an interger from 1 to 3; and at least one compound selected from a group of organotin compounds comprising bis (tri-n-butyl tin) mesodibromosuccinate, tripenyl tin monochloroacetate, triphenyl tin hydroxide and bis (tri-n-butyl tin) oxide.

  一种针对水生生物的驱避剂，其特征在于作为有效成分包含至少一种由通式表示的 N-芳基马来酰亚胺化合物： 其中：X 和 X2 是相同或不同的，分别表示氢原子和卤素原子；Y 是卤素原子、烷基或低级烷氧基；n 是 0 或 1 至 3 的中间值；以及至少一种选自有机锡化合物组的化合物，该组有机锡化合物包括双（三正丁基锡）间二溴琥珀酸酯、三烯基锡一氯乙酸酯、三苯基氢氧化锡和双(三正丁基锡)氧化物。
• NAGIEV, YA. M.;SHAGAS, G. G.;SAPOZHNIKOV, YU. E.;BAGIROV, SH. T.;ADIGEZAL+, AZERB. XIM. ZH.,(1986) N 4, 56-59
  作者：NAGIEV, YA. M.、SHAGAS, G. G.、SAPOZHNIKOV, YU. E.、BAGIROV, SH. T.、ADIGEZAL+

  DOI：——

  日期：——
• US4111879A
  申请人：——

  公开号：US4111879A

  公开（公告）日：1978-09-05
• A new class of pyrrolo[2,3-<i>b</i>]quinoxalines: synthesis, anticancer and antimicrobial activities
  作者：Bader A. Salameh、Eman H. Al-Hushki、Wamidh H. Talib、Raed Ghanem、Fatima-Azzahra Delmani、Asma I. Mahmod

  DOI：10.1515/znb-2023-0050

  日期：——

  A series of 3-chloro-1-aryl-4-dihydro-2H-pyrrolo[2,3-b]quinoxalin-2-ones and 3-chloro-1-aryl-6,7-dimethyl-1,4-dihydro-2H-pyrrolo[2,3-b]quinoxalin-2-ones was prepared by the condensation of o-phenylenediamine or 4,5-dimethyl-1,2-aminobenzene with N-aryl-3,4-dichloro-maleimides. All the prepared quinoxalines were tested for their antitumor activity against three human cancer cell lines (prostate cells PC3, colorectal cells Caco-2, and cervical cells HeLa), and a mammalian cell line (Vero cells). The compounds were also tested for their antibacterial properties against three different bacterial cells Escherichia coli, Bacillus spizizenii, and Pseudomonas aeruginosa. The compounds 3c, 3d, 3g, 3h, 3i and 4a, 4b, 4h showed anti-proliferative activity against the tested cell lines. Regarding their antibacterial activity, compounds 3a, 3g, 4a, and 4h showed inhibitory activity against E. coli, and B. spizizenii only.
• CN116514823
  申请人：——

  公开号：——

  公开（公告）日：——