Synthesis and properties of natural occurring α-hydroxyaldehydes
作者:Werner Kern、Gerhard Spiteller
DOI:10.1016/0040-4020(96)00089-0
日期:1996.3
of hog liver esterase. Aliphatic α-hydroxyaldehydes, recently recognized to be produced in the course of lipid-peroxidation of linoleic and other unsaturated fatty acids, are only stable for short time in solution. They react with amines to give Schiff bases. These are instable, but can be trapped after reduction with NaBH4 to the corresponding amines. Since α-hydroxyaldehydes are produced in the case
The reactions of bis (trimethylsilyl) peroxide with alkyl, vinyl, alkynyl, aromatic and heteroaromatic anions are described. Depending on the reaction conditions, the trimethylsilyloxy derivatives can be obtained alone or together with the corresponding trimethylsilyl derivatives, which is sometimes the major product. Enolates, generated using magnesium diisopropylamide give the corresponding hydroxycarbonyl
Diastereoselective Synthesis of α-Oxyaminesvia Gold-, Silver- and Copper-Catalyzed, Three-Component Couplings of α-Oxyaldehydes, Alkynes, and Amines in Water
作者:Baosheng Huang、Xiaoquan Yao、Chao-Jun Li
DOI:10.1002/adsc.200606118
日期:2006.8
The three-componentcouplings of α-oxyaldehydes, alkynes, and amines in water were investigated by using gold, silver and copper catalysts. Gold(I) was found to be the most effective catalyst in this reaction to afford propargylamines in good yields and moderate diastereoselectivities. On the other hand, silver catalysts show the best catalytic activities on non-coordinating α-alkyl-substituted aldehydes
3-(Dimethoxyphosphorylmethyl)cyclopent-2-enone was converted into (+/-)-prostaglandin B1 methyl ester in two steps involving regioselective alkylation at C(2) with methyl 7-iodoheptanoate and subsequent Horner-Wittig reaction with dimer of 2-hydroxyheptanal (42% overall yield). The use of (R)- and (S)-2-(tert-butyldimethylsilyloxy)heptanal for the Horner olefination reaction gave, after deprotection
A Novel Approach to γ-Hydroxy-α,β-unsaturated
Compounds
作者:Henryk Krawczyk、Katarzyna Wąsek、Jacek Kędzia
DOI:10.1055/s-0028-1083162
日期:——
A simple synthesis of (E)-alk-1-enyl mesylates from (E)-alk-1-enylphosphonates is reported. Construction of γ-hydroxy-α,β-unsaturated compounds was achieved by a two-step process involving dihydroxylation of the enol mesylates followed by HWE reaction of the resulting α-hydroxy aldehydes with activated methylphosphonates. Enantioselective synthesis of the title compounds is also reported.