2,6-dichloro-1-methylsulfonyloxymethyl-3-[N-methyl-N-(phthalimidoacetyl)amino]benzene | 167837-49-2

分子结构分类

有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物

中文名称

——

中文别名

——

英文名称

2,6-dichloro-1-methylsulfonyloxymethyl-3-[N-methyl-N-(phthalimidoacetyl)amino]benzene

英文别名

2,6-dichloro-3-[N-methyl-N-(phthalimidoacetyl)amino]benzyl methanesulfonate；2,6-dichloro-1-mesyloxymethyl-3-(N-methyl-N-phthalimidoacetylamino)benzene；[2,6-dichloro-3-[[2-(1,3-dioxoisoindol-2-yl)acetyl]-methylamino]phenyl]methyl methanesulfonate

2,6-dichloro-1-methylsulfonyloxymethyl-3-[N-methyl-N-(phthalimidoacetyl)amino]benzene化学式

CAS

167837-49-2

化学式

C₁₉H₁₆Cl₂N₂O₆S

mdl

——

分子量

471.318

InChiKey

MCFJNQKQWFRGFZ-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

物化性质

沸点：

694.6±55.0 °C(Predicted)
密度：

1.551±0.06 g/cm3(Predicted)

计算性质

辛醇/水分配系数(LogP)：

2.5
重原子数：

30
可旋转键数：

6
环数：

3.0
sp3杂化的碳原子比例：

0.21
拓扑面积：

109
氢给体数：

0
氢受体数：

6

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide	167837-48-1	C₁₈H₁₄Cl₂N₂O₄	393.226
——	N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide	167837-47-0	C₃₄H₃₂Cl₂N₂O₄Si	631.631
——	N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindol-in-2-yl)-acetamide	167837-46-9	C₃₃H₃₀Cl₂N₂O₄Si	617.604

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	8-[2,6-dichloro-3-[N-(phthalimidoacetyl)-N-methylamino]benzyloxy]-2-methylquinoline	167834-64-2	C₂₈H₂₁Cl₂N₃O₄	534.398
——	8-[2,6-Dichloro-3-[N-(phthalimidoacetyl)-N-methylamino]benzyloxy]-2-methylquinoxaline	167837-82-3	C₂₇H₂₀Cl₂N₄O₄	535.386
——	N‐[2,4‐dichloro‐3‐({[2‐methyl‐4‐(pyridin‐2‐ylmethoxy)quinolin‐8‐yl]oxy}methyl)phenyl]‐2‐(1,3‐dioxoisoindolin‐2‐yl)‐N-methylacetamide	194928-61-5	C₃₄H₂₆Cl₂N₄O₅	641.51
——	N-[2,4-dichloro-3-({[4-(dimethylaamino)-2-methyl-8-quinolinyl]oxy}methyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide	179626-14-3	C₃₀H₂₆Cl₂N₄O₄	577.467
——	N-[2,4-dichloro-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide	179626-16-5	C₃₂H₂₈Cl₂N₄O₅	619.504
——	4-[2,6-Dichloro-3-[N-(phthalimidoacetyl)-N-methylamino]-benzyloxy]-2-methoxy-1-methyl-1H-benzimidazole	177477-26-8	C₂₇H₂₂Cl₂N₄O₅	553.401
——	N-[2,4-dichloro-3-({[2-methyl-4-(1-piperidinyl)-8-quinolinyl]oxy}methyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide	179626-15-4	C₃₃H₃₀Cl₂N₄O₄	617.532
——	4-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(1-piperidinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N-(4-pyridinylmethyl)benzamide	——	C₄₁H₄₀Cl₂N₆O₄	751.712
——	4-[2,6-Dichloro-3-[N-[4-(dimethylcarbamoyl)cinnamoylglycyl]-N-methylamino]benzyloxy]-2-methoxy-1-methyl-1H-benzimidazole	——	C₃₁H₃₁Cl₂N₅O₅	624.524
——	8-[3-[N-(3-Carboxycinnamoylglycyl)-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline	215238-33-8	C₃₀H₂₅Cl₂N₃O₅	578.452
——	8-[2,6-Dichloro-3-[N-[3-(methoxycarbonyl)cinnamoylglycyl]-N-methylamino]benzyloxy]-2-methylquinoline	215238-31-6	C₃₁H₂₇Cl₂N₃O₅	592.478
——	8-[3-(N-glycyl-N-methylamino)-2,6-dichlorobenzyloxy]-2-methylquinoline	167834-66-4	C₂₀H₁₉Cl₂N₃O₂	404.296
——	8-[3-[N-[(E)-3-(6-Aminopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline	167838-46-2	C₂₈H₂₅Cl₂N₅O₃	550.444
——	8-[3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline	167838-64-4	C₃₀H₂₇Cl₂N₅O₄	592.481
——	N-{4-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(1-piperidinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]phenyl}isonicotinamide	——	C₄₀H₃₈Cl₂N₆O₄	737.686
——	8-[3-[N-[(E)-3-(6-Carboxypyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline	167838-69-9	C₂₉H₂₄Cl₂N₄O₅	579.439
——	8-[2,6-Dichloro-3-[N-[(E)-3-(6-ethoxycarbonylpyridin-3-yl)acryloylglycyl]-N-methylamino]benzyloxy]-2-methylquinoline	167838-45-1	C₃₁H₂₈Cl₂N₄O₅	607.493
——	5-[(1E)-3-({2-[2,4-dichloro-3-({[4-(dimethylamino)-2-methyl-8-quinolinyl]oxy}methyl)methylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N-methyl-2-pyridinecarboxamide	179624-71-6	C₃₂H₃₂Cl₂N₆O₄	635.55
——	2-amino-N-[2,4-dichloro-3-({[4-(dimethylamino)-2-methyl-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide	179626-17-6	C₂₂H₂₄Cl₂N₄O₂	447.364
——	2-amino-N-[2,4-dichloro-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide	179626-19-8	C₂₄H₂₆Cl₂N₄O₃	489.401
——	8-[3-(N-Glycyl-N-methylamino)-2,6-dichlorobenzyloxy]-2-methylquinoxaline	167837-88-9	C₁₉H₁₈Cl₂N₄O₂	405.284
——	2-amino-N-[2,4-dichloro-3-({[2-methyl-4-(1-piperidinyl)-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide	179626-18-7	C₂₅H₂₈Cl₂N₄O₂	487.429
——	4-[3-[N-[(E)-3-(6-Acetylaminopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methoxy-1-methyl-1H-benzimidazole	——	C₂₉H₂₈Cl₂N₆O₅	611.485
——	5-[(1E)-3-({2-[2,4-dichloro-3-({[4-(dimethylamino)-2-methyl-8-quinolinyl]oxy}methyl)methylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylic acid	179624-67-0	C₃₁H₂₉Cl₂N₅O₅	622.508
——	5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylic acid	179624-69-2	C₃₃H₃₁Cl₂N₅O₆	664.545
——	ethyl 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate	179624-53-4	C₃₅H₃₅Cl₂N₅O₆	692.599
——	4-[3-(N-Glycyl-N-methylamino)-2,6-dichlorobenzyloxy]-2-methoxy-1-methyl-1H-benzimidazole	177477-27-9	C₁₉H₂₀Cl₂N₄O₃	423.299
——	2-amino-N-[2,4-dichloro-3-({[4-(1H-imidazol-1-yl)-2-methyl-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide	199106-15-5	C₂₃H₂₁Cl₂N₅O₂	470.358

反应信息

作为反应物：

描述：

2,6-dichloro-1-methylsulfonyloxymethyl-3-[N-methyl-N-(phthalimidoacetyl)amino]benzene 在 sodium hydroxide 、 WSCD*HCl 、 sodium hydride 、 1-羟基苯并三唑、一水合肼作用下，