N-(N,N-dimethyl-leucyl)-glycine | 909874-05-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(N,N-dimethyl-leucyl)-glycine
• 英文别名: (2-Dimethylamino-4-methyl-valerylamino)-essigsaeure；N-(N,N-Dimethyl-leucyl)-glycin；(Dimethyl-dl-leucyl)-glycin；2-[[2-(Dimethylamino)-4-methylpentanoyl]amino]acetic acid
• CAS: 909874-05-1
• 化学式: C₁₀H₂₀N₂O₃
• 分子量: 216.28
• InChiKey: QPOPMEKTSLGJIQ-UHFFFAOYSA-N

物化性质

• 沸点：
  391.7±27.0 °C(Predicted)
• 密度：
  1.069±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(N,N-dimethyl-leucyl)-glycine 生成 水 、 二甲胺
  参考文献：
  名称：

  Fischer,E.; Gluud, Justus Liebigs Annalen der Chemie, 1909, vol. 369, p. 250

  摘要：

  DOI：
• 作为产物：
  描述：

  2-bromo-4-methylvaleryl bromide 在 sodium hydroxide 、 水 作用下， 生成 N-(N,N-dimethyl-leucyl)-glycine
  参考文献：
  名称：

  Fischer,E.; Gluud, Justus Liebigs Annalen der Chemie, 1909, vol. 369, p. 250

  摘要：

  DOI：

文献信息

• Novel Isobaric Tandem Mass Tags for Quantitative Proteomics and Peptidomics
  申请人：Li Lingjun

  公开号：US20130078728A1

  公开（公告）日：2013-03-28

  Compositions and methods of tagging peptides and other molecules using novel isobaric tandem mass tagging reagents, including novel N,N-dimethylated amino acid 8-plex and 16-plex isobaric tandem mass tagging reagents. The tagging reagents comprise: a) a reporter group having at least one atom that is optionally isotopically labeled; b) a balancing group, also having at least one atom that is optionally isotopically labeled, and c) an amine reactive group. The tagging reagents disclosed herein serve as attractive alternatives for isobaric tag for relative and absolute quantitation (iTRAQ) and tandem mass tags (TMTs) due to their synthetic simplicity, labeling efficiency and improved fragmentation efficiency.

  使用新型等比串联质谱标记试剂标记肽和其他分子的组合物和方法，包括新型N,N-二甲基化氨基酸8-plex和16-plex等比串联质谱标记试剂。这些标记试剂包括：a）至少有一个原子可选择同位素标记的报告基团；b）至少有一个原子可选择同位素标记的平衡基团；以及c）胺基反应基团。本文披露的标记试剂作为等比标记相对和绝对定量（iTRAQ）和串联质谱标记（TMTs）的吸引人的替代品，由于其合成简单性、标记效率和改善的碎裂效率。
• Porous membrane comprising an extracellular membrane and a polyol
  申请人：Becton, Dickinson and Company

  公开号：EP1195432A2

  公开（公告）日：2002-04-10

  A porous membrane is coated with a composition which includes a reconstituted and aggregated extracellular matrix derived from the Englebreth-Holm-Swarm mouse tumor, a polyol and a pH 7.8-8.2 buffer. The coated membrane is dried, affixed to an insert portion of an assembly and received in a well of a multiwell tissue culture plate. The invention includes a method to make the coated membrane.

  在多孔膜上涂覆一种组合物，该组合物包括源自 Englebreth-Holm-Swarm 小鼠肿瘤的重组和聚集细胞外基质、多元醇和 pH 值为 7.8-8.2 的缓冲液。涂布的膜经干燥后，粘贴到组件的插入部分，并放入多孔组织培养板的孔中。本发明包括一种制作包被膜的方法。
• Modified reconstituted basement membrane composition for assay system
  申请人：Becton, Dickinson and Company

  公开号：EP1508613A2

  公开（公告）日：2005-02-23

  A modified reconstituted extracellular matrix composition is provided herein. The composition includes an extracellular matrix and at least one exogenous component selected from heparin, fibronectin and laminin. The composition may have a basic pH. Additionally, provided herein is a cell culturing system including a substrate and a coating thereon of the composition to assess potential stimulators and/or inhibitors for their effects on various cell cultures while increasing the signal dynamic range.

  本文提供了一种改良重构细胞外基质组合物。该组合物包括细胞外基质和至少一种选自肝素、纤连蛋白和层粘连蛋白的外源成分。该组合物可具有碱性 pH 值。此外，本文还提供了一种细胞培养系统，包括基质和涂覆在基质上的组合物，用于评估潜在的刺激剂和/或抑制剂对各种细胞培养物的影响，同时提高信号动态范围。
• Extracellular matrix coated surface for culturing cells
  申请人：Becton, Dickinson and Company

  公开号：EP1857545A1

  公开（公告）日：2007-11-21

  A cell culture product is provided for propagating embryonic stem cells, and maintaining their self-renewal and pluripotency characteristics for extended periods of time in culture. The cell culturing product includes a substrate; and a coating thereon deposited from a coating solution. The coating solution includes a mixture of extracellular matrix proteins and an aqueous solvent, wherein the total protein concentration in the coating solution is about 10 µg/ml to about 1mg/ml.

  提供了一种细胞培养产品，用于繁殖胚胎干细胞，并在培养过程中长时间保持其自我更新和多能特性。该细胞培养产品包括基质；以及由包衣液沉积在基质上的包衣。包衣溶液包括细胞外基质蛋白和水性溶剂的混合物，其中包衣溶液中的总蛋白浓度约为10微克/毫升至约1毫克/毫升。
• DEFINED CELL CULTURING SURFACES AND METHODS OF USE
  申请人：Corning Incorporated

  公开号：EP3323883A1

  公开（公告）日：2018-05-23

  In one aspect, there is provided a cell culturing substrate including: a cell culture surface having a film attached thereto, wherein the film includes one or more plasma polymerized monomers; and a coating on the film-coated surface, the coating deposited from a coating solution comprising one or more extracellular matrix proteins and an aqueous solvent, where the total extracellular matrix protein concentration in the coating solution is about 1 ng/mL to about lmg/mL.

  在一个方面，提供了一种细胞培养基质，包括 细胞培养表面，其上附有薄膜，其中薄膜包括一种或多种等离子聚合单体；以及涂布在薄膜表面的涂层，涂层由包含一种或多种细胞外基质蛋白和水性溶剂的涂布液沉积而成，其中涂布液中细胞外基质蛋白的总浓度约为 1 ng/mL 至约 lmg/mL。