2-苄基-1,1-二苯肼 | 59161-43-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-苄基-1,1-二苯肼
• 英文名称: 2-Benzyl-1,1-diphenylhydrazine
• CAS: 59161-43-2
• 化学式: C₁₉H₁₈N₂
• 分子量: 274.365
• InChiKey: AKSPRESAUMCQOC-UHFFFAOYSA-N

物化性质

• 沸点：
  417.2±38.0 °C(Predicted)
• 密度：
  1.126±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-苄基-1,1-二苯肼 在 甲醇 、 正丁基锂 、 samarium diiodide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 2.0h， 生成 N-苄基三氟乙酰胺
  参考文献：
  名称：

  Trifluoroacetyl-Activated Nitrogen−Nitrogen Bond Cleavage of Hydrazines by Samarium(II) Iodide

  摘要：

  Trifluoroacetyl derivatives of hydrazines undergo clean and efficient reductive cleavage of the N-N bond with SmI2 in the presence of MeOH. After N-trifluoroacetylation, acyl-, aryl-, and alkyl-substituted hydrazines are reductively cleaved by this method to afford trifluoroacetamides in yields ranging from 70 to 96%. These conditions accommodate alkene functionality, avoid racemization, and furnish chiral amines bearing a readily removable TFA protecting group.

  DOI：

  10.1021/ol036480r
• 作为产物：
  描述：

  benzaldehyde diphenylhydrazone 在 三氟化硼乙醚 、 三正丁基氢锡 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以92%的产率得到2-苄基-1,1-二苯肼
  参考文献：
  名称：

  BF3-promoted hydrostannation of N-heteroatom-substituted imines for the reduction of CN bond

  摘要：

  Hydrostannation of n-heteroatom-substituted imines such as oxime ethers, hydrazones, oximes, nitrones, and V-sulfonyl imines using a combination of Bu3SnH and (BF3OEt2)-O-. has been systematically studied. Not only aromatic aldimines but also kitimines and aliphatic imines were reduced to give the corresponding amines. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00785-2

文献信息

• BF3-promoted hydrostannation of N-heteroatom-substituted imines for the reduction of CN bond
  作者：Masafumi Ueda、Hideto Miyabe、Megumi Namba、Toshiki Nakabayashi、Takeaki Naito

  DOI：10.1016/s0040-4039(02)00785-2

  日期：2002.6

  Hydrostannation of n-heteroatom-substituted imines such as oxime ethers, hydrazones, oximes, nitrones, and V-sulfonyl imines using a combination of Bu3SnH and (BF3OEt2)-O-. has been systematically studied. Not only aromatic aldimines but also kitimines and aliphatic imines were reduced to give the corresponding amines. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Trifluoroacetyl-Activated Nitrogen−Nitrogen Bond Cleavage of Hydrazines by Samarium(II) Iodide
  作者：Hui Ding、Gregory K. Friestad

  DOI：10.1021/ol036480r

  日期：2004.2.1

  Trifluoroacetyl derivatives of hydrazines undergo clean and efficient reductive cleavage of the N-N bond with SmI2 in the presence of MeOH. After N-trifluoroacetylation, acyl-, aryl-, and alkyl-substituted hydrazines are reductively cleaved by this method to afford trifluoroacetamides in yields ranging from 70 to 96%. These conditions accommodate alkene functionality, avoid racemization, and furnish chiral amines bearing a readily removable TFA protecting group.